Measurements and modelling of the compliance of human and porcine organs

Carter, Fiona J.; Frank, T. G.; Davies, Penny J.; McLean, Donald; Cuschieri, Alfred

doi:10.1016/s1361-8415(01)00048-2

Cited by 236 publications

(163 citation statements)

References 9 publications

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“…For example liver compliance, as measured by surface indentation, is much lower in the pig (that is, the pig liver is less elastic) when compared to man. 20 Potentially important species differences are known to exist in the structure of the hepatic sinusoids, in particular the size of the fenestrae and the prominence of the subendothelial connective tissues. 21,22 The level of gene delivery achieved in man, and therefore the precise manner of clinical application, will be defined only in early clinical trials.…”

Section: Discussionmentioning

confidence: 99%

Hydrodynamic gene delivery to the pig liver via an isolated segment of the inferior vena cava

et al. 2007

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Hydrodynamic gene delivery is an attractive option for non-viral liver gene therapy, but requires evaluation of efficacy, safety and clinically applicable techniques in large animal models. We have evaluated retrograde delivery of DNA to the whole liver via the isolated segment of inferior vena cava (IVC) draining the hepatic veins. Pigs (18-20 kg weight) were given the pGL3 plasmid via two programmable syringe pumps in parallel. Volumes corresponding to 2% of body weight (360-400 ml) were delivered at 100 ml s À1 via a Y connector. The IVC segment pressure, portal venous pressure, arterial pressure, electrocardiogram (ECG) and pulse were monitored. Concurrent studies were performed in rats for interspecies comparisons. The hydrodynamic procedure generated intrahepatic vascular pressures of 101-126 mm Hg, which is B4 times higher than in rodents, but levels of gene delivery were B200-fold lower. Suprahepatic IVC clamping caused a fall in arterial pressure, with the development of ECG signs of myocardial ischaemia, but these abnormalities resolved rapidly. The IVC segment approach is a clinically acceptable approach to liver gene therapy. However, it is less effective in pigs than in rodents, possibly because of larger liver size or a less compliant connective tissue framework.

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Section: Discussionmentioning

confidence: 99%

Hydrodynamic gene delivery to the pig liver via an isolated segment of the inferior vena cava

et al. 2007

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“…When preparing the formulation, the vehicle should have certain mechanical strength as many native tissues have moduli in the kPa range (Carter et al, 2001;Aamer et al, 2004). Otherwise, the gelling agent is likely to diffuse out of the depot and into the surrounding tissue since the fluid flow in subcutaneous tissue usually ranges from 7 to 53 mL/100 g per minute (Schoenhammer et al, 2009;Supper et al, 2014).…”

Section: Rheological Measurementmentioning

confidence: 99%

Self-assembled drug delivery system based on low-molecular-weight bis-amide organogelator: synthesis, properties and in vivo evaluation

Cao

et al. 2016

Drug Delivery

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(2016) Self-assembled drug delivery system based on low-molecular-weight bisamide organogelator: synthesis, properties and invivo evaluation, Drug Delivery, 23:8, 3168-3178, DOI: 10.3109/10717544.2016 RESEARCH ARTICLESelf-assembled drug delivery system based on low-molecular-weight bis-amide organogelator: synthesis, properties and in vivo evaluation Zhen Li, Jinxu Cao, Heran Li, Hongzhuo Liu, Fei Han, Zhenyun Liu, Chao Tong, and Sanming Li School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning, P.R. China Abstract Context: Orgnaogels based on amino acid derivatives have been widely used in the area of drug delivery. Objective: An organogel system based on L-lysine derivatives was designed and prepared to induce a thermal sensitive implant with higher transition temperature, better mechanical strength, and shorter gelation time. Materials and methods: The organogel was prepared by injectable soybean oil and methyl (S)-2,5-ditetradecanamidopentanoate (MDP), which was synthesized for the first time. Candesartan cilexetil (CC) was chosen as model drug. Different formulations were designed and optimized by response surface method. Thermal, rheology properties, and gelation kinetics of the optimized formulation had been characterized. The release behaviors in vitro, as well as in vivo were evaluated in comparison with the oily solution of drugs. Finally, the local inflammation response of in situ organogel was assessed by histological analysis. Results and discussion: Results showed that the synthesized gelator, MDP, had a good gelation ability and the organogels obtained via the self-assembly of gelators in vegetable oils exhibited great thermal and rheology properties, which guaranteed their state in body. In vivo pharmacokinetic demonstrated that the organogel formulation could extend the drug release and maintain a therapeutically effective plasma concentration at least 10 d. In addition, this implant showed acceptable moderate inflammation. Conclusion: The in situ forming L-lysine-derivative-based organogel could be a promising matrix for sustained drug delivery of the drugs with low solubility. KeywordsBiocompatibility, gelator, in situ implant system, in vivo release, organogel History

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“…With the design of its Tissue Material Property Sampling Tool (TeMPeST), in parallel with Carter et al [4], Mark Ottensmeyer [1] pioneered development of an indentation tool that could be used on in vivo tissues. The objective was to drastically reduce the size of the device in comparison with what is usually provided by commercial indentation machines.…”

Section: In Vivo Devices: State Of the Artmentioning

confidence: 99%

LASTIC: A Light Aspiration Device for in vivo Soft TIssue Characterization

Schiavone

Promayon

Payan

2010

Biomedical Simulation

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Abstract. This paper introduces a new Light Aspiration device for in vivo Soft TIssue Characterization (LASTIC). This device is designed to be used during surgery, and can undergo sterilization. It provides interactive-time estimation of the elastic parameters. LASTIC is a 3cm x 3cm metallic cylinder divided in two compartments. The lower compartment is a cylindrical chamber made airtight by a glass window in which a negative pressure can be applied. Put in contact with soft tissues, it can aspirate the tissues into the chamber through a circular aperture in its bottom side. The upper compartment is clinched onto the lower part. A miniature digital camera is fixed inside the upper chamber, focusing on the aspirated soft tissue. LASTIC is operated by applying a range of negative pressures in the lower compartment while measuring the resulting aspirated tissue deformations with the digital camera. These measurements are used to estimate the tissue elasticity parameters by inverting a Finite Element model of the suction experiment. In order to use LAS-TIC during surgical interventions, a library-based optimization process is used to provide an interactive time inversion.

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Measurements and modelling of the compliance of human and porcine organs

Cited by 236 publications

References 9 publications

Hydrodynamic gene delivery to the pig liver via an isolated segment of the inferior vena cava

Hydrodynamic gene delivery to the pig liver via an isolated segment of the inferior vena cava

Self-assembled drug delivery system based on low-molecular-weight bis-amide organogelator: synthesis, properties and in vivo evaluation

LASTIC: A Light Aspiration Device for in vivo Soft TIssue Characterization

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