Measurement of Vascular Rigidity in the Living Eye

Aqueous Humor Dynamics in α-Chymotrypsin-Induced Ocular Hypertensive Rabbits

“…On the other hand, since no significant difference was observed between the mean tonographic outflow facility in a-chymotrypsin-induced ocular hypertensive rabbits and ocular normotensive rabbits, our data clearly conflict with the classical hypothesis on the mechanism of the ocular hypertension observed in rabbits following intracameral injection of a-chymotrypsin, that states that a decrease in aqueous humor outflow is responsible for the rise in intraocular pressure (4). On the contrary, our findings suggest that ocular hypertension following a-chymotrypsin injection may be caused by an increase in the rate of aqueous humor inflow, as it was estimated to be about 1.5-fold higher than that of ocular normotensive rabbits.…”

“…Furthermore, the need of injecting a-chymotrypsin into the posterior chamber of the eye to induce ocular hypertension would be also satisfactorily supported by this approach, since both actions would be produced at this locus. In this regard, some studies have reported changes in the structure of the ciliary body after the injection of achymotrypsin into the posterior chamber of rabbit eyes (4).…”

Aqueous Humor Dynamics in α-Chymotrypsin-Induced Ocular Hypertensive Rabbits

“…On the other hand, since no significant difference was observed between the mean tonographic outflow facility in a-chymotrypsin-induced ocular hypertensive rabbits and ocular normotensive rabbits, our data clearly conflict with the classical hypothesis on the mechanism of the ocular hypertension observed in rabbits following intracameral injection of a-chymotrypsin, that states that a decrease in aqueous humor outflow is responsible for the rise in intraocular pressure (4). On the contrary, our findings suggest that ocular hypertension following a-chymotrypsin injection may be caused by an increase in the rate of aqueous humor inflow, as it was estimated to be about 1.5-fold higher than that of ocular normotensive rabbits.…”

“…Furthermore, the need of injecting a-chymotrypsin into the posterior chamber of the eye to induce ocular hypertension would be also satisfactorily supported by this approach, since both actions would be produced at this locus. In this regard, some studies have reported changes in the structure of the ciliary body after the injection of achymotrypsin into the posterior chamber of rabbit eyes (4).…”

Modeling NO Biotransport in Brain Using a Space-Fractional Reaction-Diffusion Equation

“…Also, methods that reduce the neurotoxicity of these NO probes, so that they are safe to use in human subjects, are emerging (Sudarshana et al, 2019). However, an image showing a low NO concentration alone or in combination with a measurement of stiffer retinal vessels done during an eye exam (Best et al, 1971;Flammer et al, 2013) will just indicate the presence of endotheliopathy in patients with COVID-19, which, as mentioned earlier, can already be found with blood tests.…”

Effects of intracameral administration of α-chymotrypsin on intracapsular lens extraction and postoperative outcome in clinically normal dogs

“…Of the signs commonly ascribed to a-chymotrypsin administration in dogs, perhaps the best understood is ocular hypertension, which also has been detected in humans, 36 primates, 37 and rabbits. 38 In fact, ocular hypertension is so reliably induced by intraocular administration of a-chymotrypsin in rabbits that this has been used as a method of inducing elevated IOP in rabbits to enable the study of glaucoma. 39 Ocular hypertension following intraocular administration of a-chymotrypsin is believed to be attributable to accumulation of lens zonular fibers in the ICA.…”

Aqueous Humor Dynamics in α-Chymotrypsin-Induced Ocular Hypertensive Rabbits

“…On the other hand, since no significant difference was observed between the mean tonographic outflow facility in a-chymotrypsin-induced ocular hypertensive rabbits and ocular normotensive rabbits, our data clearly conflict with the classical hypothesis on the mechanism of the ocular hypertension observed in rabbits following intracameral injection of a-chymotrypsin, that states that a decrease in aqueous humor outflow is responsible for the rise in intraocular pressure (4). On the contrary, our findings suggest that ocular hypertension following a-chymotrypsin injection may be caused by an increase in the rate of aqueous humor inflow, as it was estimated to be about 1.5-fold higher than that of ocular normotensive rabbits.…”

“…Furthermore, the need of injecting a-chymotrypsin into the posterior chamber of the eye to induce ocular hypertension would be also satisfactorily supported by this approach, since both actions would be produced at this locus. In this regard, some studies have reported changes in the structure of the ciliary body after the injection of achymotrypsin into the posterior chamber of rabbit eyes (4).…”

Modeling NO Biotransport in Brain Using a Space-Fractional Reaction-Diffusion Equation

“…Also, methods that reduce the neurotoxicity of these NO probes, so that they are safe to use in human subjects, are emerging (Sudarshana et al, 2019). However, an image showing a low NO concentration alone or in combination with a measurement of stiffer retinal vessels done during an eye exam (Best et al, 1971;Flammer et al, 2013) will just indicate the presence of endotheliopathy in patients with COVID-19, which, as mentioned earlier, can already be found with blood tests.…”

Effects of intracameral administration of α-chymotrypsin on intracapsular lens extraction and postoperative outcome in clinically normal dogs

“…Of the signs commonly ascribed to a-chymotrypsin administration in dogs, perhaps the best understood is ocular hypertension, which also has been detected in humans, 36 primates, 37 and rabbits. 38 In fact, ocular hypertension is so reliably induced by intraocular administration of a-chymotrypsin in rabbits that this has been used as a method of inducing elevated IOP in rabbits to enable the study of glaucoma. 39 Ocular hypertension following intraocular administration of a-chymotrypsin is believed to be attributable to accumulation of lens zonular fibers in the ICA.…”

Aqueous Humor Dynamics in α-Chymotrypsin-Induced Ocular Hypertensive Rabbits

“…On the other hand, since no significant difference was observed between the mean tonographic outflow facility in a-chymotrypsin-induced ocular hypertensive rabbits and ocular normotensive rabbits, our data clearly conflict with the classical hypothesis on the mechanism of the ocular hypertension observed in rabbits following intracameral injection of a-chymotrypsin, that states that a decrease in aqueous humor outflow is responsible for the rise in intraocular pressure (4). On the contrary, our findings suggest that ocular hypertension following a-chymotrypsin injection may be caused by an increase in the rate of aqueous humor inflow, as it was estimated to be about 1.5-fold higher than that of ocular normotensive rabbits.…”

“…Furthermore, the need of injecting a-chymotrypsin into the posterior chamber of the eye to induce ocular hypertension would be also satisfactorily supported by this approach, since both actions would be produced at this locus. In this regard, some studies have reported changes in the structure of the ciliary body after the injection of achymotrypsin into the posterior chamber of rabbit eyes (4).…”

Modeling NO Biotransport in Brain Using a Space-Fractional Reaction-Diffusion Equation

“…Also, methods that reduce the neurotoxicity of these NO probes, so that they are safe to use in human subjects, are emerging (Sudarshana et al, 2019). However, an image showing a low NO concentration alone or in combination with a measurement of stiffer retinal vessels done during an eye exam (Best et al, 1971;Flammer et al, 2013) will just indicate the presence of endotheliopathy in patients with COVID-19, which, as mentioned earlier, can already be found with blood tests.…”

Effects of intracameral administration of α-chymotrypsin on intracapsular lens extraction and postoperative outcome in clinically normal dogs

“…Of the signs commonly ascribed to a-chymotrypsin administration in dogs, perhaps the best understood is ocular hypertension, which also has been detected in humans, 36 primates, 37 and rabbits. 38 In fact, ocular hypertension is so reliably induced by intraocular administration of a-chymotrypsin in rabbits that this has been used as a method of inducing elevated IOP in rabbits to enable the study of glaucoma. 39 Ocular hypertension following intraocular administration of a-chymotrypsin is believed to be attributable to accumulation of lens zonular fibers in the ICA.…”