Measurement of lung volumes by plethysmography

Coates, Allan L.; Peslin, R; Rodenstein, Daniel; Stocks, Janet

doi:10.1183/09031936.97.10061415

Cited by 142 publications

(115 citation statements)

References 38 publications

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“…Consistent with previous studies (3,6,7,21,(36)(37)(38)40), we obtained a rather low R 2 and high SEE in the LV prediction, i.e., a substantial percentage of the LV variance could not be explained by the variables analyzed (Table 5). These results are consistent with the traditional notion that LV are far less reproducible than spirometric variables, reinforcing the necessity of using accurate and representative reference values.…”

Section: Discussionsupporting

confidence: 79%

“…Predictive studies for North American and European populations found lower values in minorities such as blacks or Hispanics, but their lower socioeconomic and nutritional status are probably important confounding factors (4,7,21). Studies with immigrants suggest that intermarriage can induce LV values which are intermediate between the parents (32,35).…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, this was not the case: prediction equations derived from predominantly Caucasian samples had a non-parallel error in the prediction of our original data. In this context, it should be noted that although height (the main independent variable) has a quite obvious relationship with the lung base-apex distance, it contains little information about the total chest diameter (7,21); by the same token, little is known about the leg-trunk ratio of South American populations. These variations could explain the errors found in the ATS/ERS equations in predicting our observed values (7) (Figure 3).…”

Section: Discussionmentioning

confidence: 99%

“…Personnel, technique, procedures and calibration were standardized (7,(20)(21)(22). The reported values are the mean of at least three acceptable determinations which agreed within 10% of the largest value.…”

Section: Static Lung Volumesmentioning

confidence: 99%

See 3 more Smart Citations

Reference values for lung function tests: I. Static volumes

Neder

Andreoni

Castelo-Filho

et al. 1999

Braz J Med Biol Res

256

175

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Static lung volume (LV) measurements have a number of clinical and research applications; however, no previous studies have provided reference values for such tests using a healthy sample of the adult Brazilian population. With this as our main purpose, we prospectively evaluated 100 non-smoking subjects (50 males and 50 females), 20 to 80 years old, randomly selected from more than 8,000 individuals. Gender-specific linear prediction equations were developed by multiple regression analysis with total lung capacity (TLC), functional residual capacity (FRC), residual volume (RV), RV/TLC ratio and inspiratory capacity (IC) as dependent variables, and with age, height, weight, lean body mass and indexes of physical fitness as independent ones. Simpler demographic and anthropometric variables were as useful as more complex measurements in predicting LV values, independent of gender and age (R 2 values ranging from 0.49 to 0.78, P<0.001). Interestingly, prediction equations from North American and European studies overestimated the LV at low volumes and underestimated them at high volumes (P<0.05). Our results, therefore, provide a more appropriate frame of reference to evaluate the normalcy of static lung volume values in Brazilian males and females aged 20 to 80 years.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Static Lung Volumesmentioning

confidence: 99%

See 2 more Smart Citations

Reference values for lung function tests: I. Static volumes

Neder

Andreoni

Castelo-Filho

et al. 1999

Braz J Med Biol Res

256

175

View full text Add to dashboard Cite

show abstract

“…Pulmonary function tests were conducted in accordance with recognised standards [16][17][18][19]. Evaluation of pulmonary function parameters was performed using the following definitions: "trough" values were measured pre-dose on days 21 and 42, i.e.…”

Section: Pulmonary Function Testingmentioning

confidence: 99%

Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD

O’Donnell¹,

Flüge²,

Gerken³

et al. 2004

Eur Respir J

759

581

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The aim of this study was to test the hypothesis that use of tiotropium, a new long-acting anticholinergic bronchodilator, would be associated with sustained reduction in lung hyperinflation and, thereby, would improve exertional dyspnoea and exercise performance in patients with chronic obstructive pulmonary disease.A randomised, double-blind, placebo-controlled, parallel-group study was conducted in 187 patients (forced expiratory volume in one second 44 ¡ 13% pred): 96 patients received 18 mg tiotropium and 91 patients received placebo once daily for 42 days. Spirometry, plethysmographic lung volumes, cycle exercise endurance and exertional dyspnoea intensity at 75% of each patient9s maximal work capacity were compared.On day 42, the use of tiotropium was associated with the following effects at pre-dose and post-dose measurements as compared to placebo: vital capacity and inspiratory capacity (IC) increased, with inverse decreases in residual volume and functional residual capacity. Tiotropium increased post-dose exercise endurance time by 105¡40 s (21%) as compared to placebo on day 42. At a standardised time near end-exercise (isotime), IC, tidal volume and minute ventilation all increased, whilst dyspnoea decreased by 0.9¡0.3 Borg scale units.In conclusion, the use of tiotropium was associated with sustained reductions of lung hyperinflation at rest and during exercise. Resultant increases in inspiratory capacity permitted greater expansion of tidal volume and contributed to improvements in both exertional dyspnoea and exercise endurance.

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Lung Volumes

Cotes¹

2020

Cotes’ Lung Function

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Measurement of lung volumes by plethysmography

Cited by 142 publications

References 38 publications

Reference values for lung function tests: I. Static volumes

Reference values for lung function tests: I. Static volumes

Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD

Lung Volumes

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