Patient-to-patient differences should be accounted for in both clinical evaluations and computational models of knee laxity. Accordingly, the objectives were to determine how variable the laxities are between knees by determining the range of the internal-external (I-E), varus-valgus (V-V), anterior-posterior (A-P), and compression-distraction (C-D) limits of passive motion, and how related the laxities are within a knee by determining whether these limits are correlated with one another. The limits in I-E (AE 3 Nm), V-V (AE 5 Nm), A-P (AE 45 N), and C-D (AE 100 N) were measured in 10 normal human cadaveric knees at 0˚to 120˚flexion in 15i ncrements using a six degree-of-freedom load application system. The ranges from 15˚to 120˚flexion of the I-E limits were greater than 3.6˚, of the A-P limits were greater than 1.8 mm, and of the varus limits were greater than 1.4˚. The ranges from 30˚to 120f exion of the distraction limits were greater than 2.0 mm. Twenty-four of the 28 pair-wise comparisons between the limits had a correlation coefficient less than 0.65. These results demonstrate that a patient-specific approach, including all degrees of freedom of interest, is necessary during clinical evaluations of laxity and when creating and validating computational models of the tibiofemoral joint. Keywords: limits of passive motion; patient-specific modeling; laxity; knee It is important to characterize the patient-to-patient differences in the laxities of the tibiofemoral joint of the normal human knee in various degrees of freedom. The laxities of the normal human knee are often used both as a benchmark by orthopedic surgeons when evaluating laxities before, during, and after surgical interventions (e.g., total knee arthroplasty) 1 and as a gold standard by researchers when validating computational models of the tibiofemoral joint.2,3 Passive kinematics of the tibiofemoral joint are guided by the interaction between the soft tissue restraints and the articular geometry. However, the restraints from both the soft tissues and articular geometry are different between individuals. 4 Because the laxities are a measure of the function of the soft tissue restraints and the articular geometry, abnormal laxities indicate abnormal function. Therefore, it is critical to characterize the patientto-patient differences in the laxities so they may be accounted for during clinical evaluations of laxity and when creating computational models of the knee to study the behavior of the soft tissue restraints.There are two types of patient-to-patient differences that are of interest with regards to the laxities of the tibiofemoral joint. The first is the variability of the laxities between knees. If there is a wide variability as characterized by a wide range of the laxities, then a patient-specific approach would be necessary both during clinical evaluations of laxity and when creating computational models of the knee to study the behavior of the soft tissue restraints. The second is the relationship between the laxity in one ...