Measurement of insulin-like growth factor binding protein-1 in cervical/vaginal secretions: comparison with the ROM-check membrane immunoassay in the diagnosis of ruptured fetal membranes

Rutanen, Eeva‐Marja; Pekonen, Fredrika; Kärkkäinen, Tytti

doi:10.1016/0009-8981(93)90304-m

Cited by 72 publications

(56 citation statements)

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“…IGFBP-1 levels were measured by an immunoradiometric assay using two monoclonal antibodies to IGFBP-1 (Mab6303 and Mab6305) according to a previously described method [12,13]. The intra-and inter-assay coefficients of variation were 2.87 to 4.84% and 5.61 to 15.4%, respectively.…”

Section: Assaysmentioning

confidence: 99%

Increased Circulating Levels of Insulin-Like Growth Factor-I and Decreased Circulating Levels of Insulin-Like Growth Factor Binding Protein-1 in Postmenopausal Women with Endometrial Cancer.

et al. 1997

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Abstract. In human endometrium insulin-like growth factor binding protein (IGFBP)-1 inhibits the mitogenic action of insulin-like growth factor (IGF)-I by inhibiting the binding of IGF-I to its receptor. Our purpose was to compare circulating levels of IGF-I and IGFBP-1 in women with and without endometrial cancer. We assessed circulating levels of IGF-I and IGFBP-1 and IGFBP-3 in 23 patients with endometrial cancer, 11 patients with uterine cervical cancer and 27 healthy control women. The mean circulating level of IGF-I decreased significantly following menopause but was not correlated with age in the control group. The body mass index was significantly higher in the endometrial cancer group than in the control group. Analysis of covariance showed that even after the data were adjusted to eliminate the influence of the body mass index, the circulating IGF-I concentration was higher in postmenopausal endometrial cancer patients than in postmenopausal control subjects. The mean circulating level of IGFBP-1 was significantly lower in postmenopausal cancer patients than in postmenopausal control subjects. There were no significant differences in the serum levels of IGF-I and IGFBP-1 in the patients with cervical cancer and the control group. In conclusion, an increased circulating concentration of IGF-I and a decreased circulating concentration of IGFBP-1 are associated with endometrial cancer especially in postmenopausal women.

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Section: Assaysmentioning

confidence: 99%

Increased Circulating Levels of Insulin-Like Growth Factor-I and Decreased Circulating Levels of Insulin-Like Growth Factor Binding Protein-1 in Postmenopausal Women with Endometrial Cancer.

et al. 1997

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“…La fibronectine foetale est un autre biomarqueur dont la sensibilité et la spécificité sont plus élevées, respectivement de 92-94 % et 80-97 % [17]. L'inconvénient de ce test est que la protéine détectée provient majoritairement des membranes foetales et non du liquide amniotique.…”

Section: Discussionunclassified

Analyse comparative de deux tests diagnostiques de rupture prématurée des membranes dans les sécrétions cervico-vaginales

Marcellin¹,

Anselem²,

Gadrey³

et al. 2011

Journal de Gynécologie Obstétrique et Biologie de la Reproducti

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“…The Zscores of free IGF-I, total IGF-I, and IGFBP-3 were calculated by using age-matched normal values [4, 5, our unpublished data]. In 18 young adults with IDDM (age 18.0-30.3 years, 5 males and 13 females), IGFBP-1 was also measured, as previously described [6]. In all subjects, four parameters of diabetic control were measured with commercially available kits: blood glucose (BS) (momentary parameter of diabetic control), 1,5-anhydro-Dglucitol (1,5 AG) (Ultrashort-term; the preceding 1 to a few days), fructosamine (short term; the preceding 1 to 2 weeks), and HbA1(long-term; the preceding 6 to 8 weeks).…”

Section: Methodsmentioning

confidence: 99%

Insulin-Like Growth Factors-Insulin-Like Growth Factor Binding Protein Axis and Diabetic Cotrol in Insulin- Dependent Diabetes Mellitus

Hasegawa

Takada³

et al. 1998

Endocr J

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Measurement of insulin-like growth factor binding protein-1 in cervical/vaginal secretions: comparison with the ROM-check membrane immunoassay in the diagnosis of ruptured fetal membranes

Cited by 72 publications

References 0 publications

Increased Circulating Levels of Insulin-Like Growth Factor-I and Decreased Circulating Levels of Insulin-Like Growth Factor Binding Protein-1 in Postmenopausal Women with Endometrial Cancer.

Increased Circulating Levels of Insulin-Like Growth Factor-I and Decreased Circulating Levels of Insulin-Like Growth Factor Binding Protein-1 in Postmenopausal Women with Endometrial Cancer.

Analyse comparative de deux tests diagnostiques de rupture prématurée des membranes dans les sécrétions cervico-vaginales

Insulin-Like Growth Factors-Insulin-Like Growth Factor Binding Protein Axis and Diabetic Cotrol in Insulin- Dependent Diabetes Mellitus

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