Measurement of Glucose Area Under the Curve Using Minimally Invasive Interstitial Fluid Extraction Technology: Evaluation of Glucose Monitoring Concepts Without Blood Sampling

Sato, Toshiyuki; Okada, Seiki; Hagino, Kei; Asakura, Yoshihiro; Kikkawa, Yasuo; Kojima, Junko; Watanabe, Toshihiro; Maekawa, Yasunori; Isobe, Kazuki; Koike, Reona; Nakajima, Hitoshi; Asano, Kaoru

doi:10.1089/dia.2011.0089

Cited by 32 publications

(24 citation statements)

References 14 publications

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“…After 4 (protocol A) or 2 (protocol B) cycles, all patches were collected to analyze ISF composition. As previously reported [6], MIET uses Na + collected simultaneously with glucose in hydrogels as an internal standard. Since Na + levels in ISF are supposed to be constant inter- and intraindividual, calibration can be completed without blood glucose levels.…”

Section: Methodsmentioning

confidence: 99%

“…A detailed description of our procedures has been provided in our earlier reports [69]. Briefly, the hydrogel was separated from the adhesive tape and immersed into pure water to extract glucose and sodium.…”

Section: Methodsmentioning

confidence: 99%

“…Details and principles of data analysis for calculating MIET-AUC have been previously described [6]. …”

Section: Methodsmentioning

confidence: 99%

“…We have developed a novel system to measure glucose area under the curve (AUC) using minimally invasive interstitial fluid extraction technology (MIET) [67]. This easy-to-use system requires no blood sampling and is expected to provide simple and convenient monitoring for glycemic excursion.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of a Novel Glucose Area Under the Curve (AUC) Monitoring System: Comparison with the AUC by Continuous Glucose Monitoring

et al. 2016

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BackgroundManagement of postprandial hyperglycemia is a key aspect in diabetes treatment. We developed a novel system to measure glucose area under the curve (AUC) using minimally invasive interstitial fluid extraction technology (MIET) for simple monitoring of postprandial glucose excursions. In this study, we evaluated the relationship between our system and continuous glucose monitoring (CGM) by comparing glucose AUC obtained using MIET with that obtained using CGM for a long duration.MethodsTwenty diabetic inpatients wearing a CGM system were enrolled. For MIET measurement, a plastic microneedle array was applied to the skin as pretreatment, and hydrogels were placed on the pretreated area to collect interstitial fluid. Hydrogels were replaced every 2 or 4 hours and AUC was predicted on the basis of glucose and sodium ion levels.ResultsAUC predicted by MIET correlated well with that measured by CGM (r=0.93). Good performances of both consecutive 2- and 4-hour measurements were observed (measurement error: 11.7%±10.2% for 2 hours and 11.1%±7.9% for 4 hours), indicating the possibility of repetitive measurements up to 8 hours. The influence of neither glucose fluctuation nor average glucose level over the measurement accuracy was observed through 8 hours.ConclusionOur system showed good relationship with AUC values from CGM up to 8 hours, indicating that single pretreatment can cover a large portion of glucose excursion in a day. These results indicated possibility of our system to contribute to convenient monitoring of glucose excursions for a long duration.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…Details and principles of data analysis for calculating MIET-AUC have been previously described [6]. …”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of a Novel Glucose Area Under the Curve (AUC) Monitoring System: Comparison with the AUC by Continuous Glucose Monitoring

et al. 2016

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“…As postprandial glucose levels relate most closely to HbA1c values in people with well-controlled T1D, new techniques to evaluate postprandial glucose excursions may be helpful. 62 …”

Section: Use Of Cgmmentioning

confidence: 99%

Recent Advances in the Prevention of Hypoglycemia in Type 1 Diabetes

Realsen¹,

Chase²

2011

Diabetes Technology & Therapeutics

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Iatrogenic hypoglycemia is one of the chief barriers to optimal glycemic control in people with type 1 diabetes (T1D). As a common contributor to morbidity and mortality in T1D, severe hypoglycemia (SH) is also a major fear for people with T1D and their families. Consequently, fear of hypoglycemia and hypoglycemia-avoidant behaviors are predominant limiting factors in achieving euglycemia in people with T1D. Nocturnal SH and hypoglycemia unawareness are prevalent obstacles in the detection of hypoglycemia which further impair the prevention and treatment of SH. Various strategies and technologies have already been developed to help detect and prevent hypoglycemia, including improved patient education, frequent self-monitoring of blood glucose levels, the use of rapid-acting and basal insulin analogs, continuous subcutaneous insulin infusion therapy, exercise-related insulin modifications, and continuous glucose monitors. The efficacy of these methods is well established, but further advances are still needed. The purpose of this review is to describe these currently available methods and to emphasize recent progress related to the prevention of hypoglycemia in T1D.

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Microneedles for Transdermal Biosensing: Current Picture and Future Direction

Ventrelli

Strambini

Barillaro

2015

Adv Healthcare Materials

185

126

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A novel trend is rapidly emerging in the use of microneedles, which are a miniaturized replica of hypodermic needles with length-scales of hundreds of micrometers, aimed at the transdermal biosensing of analytes of clinical interest, e.g., glucose, biomarkers, and others. Transdermal biosensing via microneedles offers remarkable opportunities for moving biosensing technologies and biochips from research laboratories to real-field applications, and envisages easy-to-use point-of-care microdevices with pain-free, minimally invasive, and minimal-training features that are very attractive for both developed and emerging countries. In addition to this, microneedles for transdermal biosensing offer a unique possibility for the development of biochips provided with end-effectors for their interaction with the biological system under investigation. Direct and efficient collection of the biological sample to be analyzed will then become feasible in situ at the same length-scale of the other biochip components by minimally trained personnel and in a minimally invasive fashion. This would eliminate the need for blood extraction using hypodermic needles and reduce, in turn, related problems, such as patient infections, sample contaminations, analysis artifacts, etc. The aim here is to provide a thorough and critical analysis of state-of-the-art developments in this novel research trend, and to bridge the gap between microneedles and biosensors.

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Measurement of Glucose Area Under the Curve Using Minimally Invasive Interstitial Fluid Extraction Technology: Evaluation of Glucose Monitoring Concepts Without Blood Sampling

Abstract: These findings validate the adequacy of glucose AUC measurements using MIET. Monitoring glucose using MIET without blood sampling may be beneficial to patients with diabetes.

Cited by 32 publications

References 14 publications

Evaluation of a Novel Glucose Area Under the Curve (AUC) Monitoring System: Comparison with the AUC by Continuous Glucose Monitoring

Evaluation of a Novel Glucose Area Under the Curve (AUC) Monitoring System: Comparison with the AUC by Continuous Glucose Monitoring

Recent Advances in the Prevention of Hypoglycemia in Type 1 Diabetes

Microneedles for Transdermal Biosensing: Current Picture and Future Direction

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