Measurement of Endogenous Carbon Monoxide Formation in Biological Systems

Marks, Gerald S.; Vreman, Hendrik J.; McLaughlin, Brian E.; Brien, James F.; Nakatsu, Kanji

doi:10.1089/152308602753666325

Cited by 86 publications

(43 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…CO is known to autoinhibit HO and thus its own synthesizing enzyme. While endogenous CO does not inhibit HO reaction (Marks et al 2002), larger amounts of exogenous CO attenuated this reaction (Yoshida et al 1980). Nevertheless, the reported vasodilatory effects of other studies (Hartsfield et al 2004;Nishikawa et al 2004;Kanu et al 2006;Hosgood et al 2008) could not be observed in this experiment.…”

Section: Co Under Physiological Conditionscontrasting

confidence: 72%

Neither inhalative nor intravenous application of carbon monoxide modifies gastric mucosal oxygenation

Vollmer

Schwartges²,

Obermiller³

et al. 2012

gpb

View full text Add to dashboard Cite

Abstract. This study was designed to compare the effects of different ways of administering carbon monoxide (intravenous and inhalative) on gastric mucosal oxygenation in a canine model of hemorrhage. Six chronically instrumented dogs were repeatedly anesthetized and randomized to each of the following protocols: In a first series the animals were ventilated either with 100 ppm carbon monoxide (CO) or without followed by hemorrhage and re-transfusion. In a second series a saturated CO solution was infused, compared to normal saline, again followed by hemorrhage and re-transfusion. In a control series, animals received either CO-saline or saline without any further intervention. Microvascular oxygenation of the gastric mucosa (µHbO 2 ) was assessed continuously by tissue reflectance spectrophotometry. Cardiac output was measured intermittently and oxygen delivery (DO 2 ) was calculated. The application of CO, inhalative and intravenous, increased carboxyhemoglobin levels without effect on µHbO 2 . Hemorrhage reduced µHbO 2 in all groups, paralleled by a reduction in DO 2 without any differences between groups related to the application of CO. Neither intravenous nor inhalative application of CO alters µHbO 2 during physiological conditions or during hemorrhage. Thus, independent of the application way, low dose CO does not seem to modulate regional mucosal oxygenation in cytoprotective concentrations.

show abstract

Section: Co Under Physiological Conditionscontrasting

confidence: 72%

Neither inhalative nor intravenous application of carbon monoxide modifies gastric mucosal oxygenation

Vollmer

Schwartges²,

Obermiller³

et al. 2012

gpb

View full text Add to dashboard Cite

show abstract

“…Therefore, the carboxyhaemoglobin concentration in the subject is a good marker of endogenous HO activity. 27 Furthermore, it has been reported that HO-1 is strongly induced in patients with bacterial infection. 28 We have already shown that arterial carboxyhaemoglobin increases at the onset of pneumonia in untreated patients returns to baseline on recovery after treatments.…”

Section: Discussionmentioning

confidence: 99%

Association of susceptibility to the development of pneumonia in the older Japanese population with haem oxygenase-1 gene promoter polymorphism

Yasuda¹,

Okinaga

Yamaya³

et al. 2005

Journal of Medical Genetics

View full text Add to dashboard Cite

Background: Oxidative stresses including cigarette smoking are implicated in the pathogenesis of cerebrovascular diseases, which are associated with pneumonia because of frequent aspiration. Haem oxygenase-1 (HO-1) acts in cytoprotection against oxidants, provides anti-inflammatory effects, and inhibits atherogenesis. A (GT) n dinucleotide repeat in the human HO-1 promoter modulates HO-1 gene expression and shows length polymorphism, which is grouped into three classes: class S (,27 repeats), class M (>27, ,33 repeats), and class L (>33 repeats) alleles. Objective: To investigate the correlation between the HO-1 gene polymorphism and development of pneumonia in elderly Japanese. Methods: The length of the (GT) n repeats was analysed in 200 elderly patients with pneumonia and 200 control subjects. The association of the HO-1 gene polymorphism with risk of pneumonia was estimated by logistic regression. Results: The proportion of allele frequencies in class L, and the proportion of genotypic frequencies in the L-allele carriers (L/L, L/M, and L/S), was significantly higher in patients with pneumonia than in controls (20% v 10% in class L, and 34% v 18% in L-allele carriers). After adjustment for potentially confounding factors, both cerebrovascular disorders and HO-1 gene L-allele carriers were significant and independent risk factors for pneumonia. The adjusted odds ratio for Lallele carriers v non-L-allele carrier was 2.1 (95% confidence interval, 1.2 to 3.6). Conclusions: The large size of a (GT) n repeat in the HO-1 gene promoter may be associated with susceptibility to pneumonia in the older Japanese population.

show abstract

“…The combination rate of NO with hemoglobin is faster and dissociation is slower than that of CO (Sharma and Ranney, 1978), so that the affinity of NO for hemoglobin is ∼1,500-times that of CO (Foresti and Motterlini, 1999). Formation of endogenous CO in a variety of tissues has been demonstrated (Marks et al, 2002). Given the complexity of colocalization and activities of heme oxygenase and nitric oxide synthase, it has been speculated that "CO and NO could function in a synergistic, compensatory, and/or counterregulatory way" (Hartsfield, 2002).…”

Section: Physiological Roles Of Carbon Monoxidementioning

confidence: 99%