Measurement of arterial transit time and renal blood flow using pseudocontinuous ASL MRI with multiple post‐labeling delays: Feasibility, reproducibility, and variation

Kim, Dong Won; Shim, Woo Hyun; Yoon, Seong Kuk; Oh, Joo Yeon; Kim, Jeong Kon; Jung, Haijo; Matsuda, Tsuyoshi; Kim, Dongeun

doi:10.1002/jmri.25634

Cited by 37 publications

(44 citation statements)

References 37 publications

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“…Our ASL values for cortical renal perfusion are in agreement with those obtained at 3 T using breath-hold multi-TI sequences: 151 ± 37 to 215 ± 65 ml/min/100 g [20,21], but even in healthy volunteers at this field strength single-TI values range between 229 ± 41 to 327 ± 63 ml/min/100 g [10,11,26]. This variation can be attributed to different acquisition schemes, kinetic models and study populations.…”

Section: Discussionsupporting

confidence: 84%

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Motion-corrected multiparametric renal arterial spin labelling at 3 T: reproducibility and effect of vasodilator challenge

et al. 2018

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Objectives We investigated the feasibility and reproducibility of free-breathing motion-corrected multiple inversion time (multi-TI) pulsed renal arterial spin labelling (PASL), with general kinetic model parametric mapping, to simultaneously quantify renal perfusion (RBF), bolus arrival time (BAT) and tissue T 1 . Methods In a study approved by the Health Research Authority, 12 healthy volunteers (mean age, 27.6 ± 18.5 years; 5 male) gave informed consent for renal imaging at 3 T using multi-TI ASL and conventional single-TI ASL. Glyceryl trinitrate (GTN) was used as a vasodilator challenge in six subjects. Flow-sensitive alternating inversion recovery (FAIR) preparation was used with background suppression and 3D-GRASE (gradient and spin echo) read-out, and images were motion-corrected. Parametric maps of RBF, BAT and T 1 were derived for both kidneys. Agreement was assessed using Pearson correlation and Bland-Altman plots. Results Inter-study correlation of whole-kidney RBF was good for both single-TI (r 2 = 0.90), and multi-TI ASL (r 2 = 0.92). Single-TI ASL gave a higher estimate of whole-kidney RBF compared to multi-TI ASL (mean bias, 29.3 ml/min/100 g; p <0.001). Using multi-TI ASL, the median T 1 of renal cortex was shorter than that of medulla (799.6 ms vs 807.1 ms, p = 0.01), and mean whole-kidney BAT was 269.7 ± 56.5 ms. GTN had an effect on systolic blood pressure (p < 0.05) but the change in RBF was not significant. Conclusions Free-breathing multi-TI renal ASL is feasible and reproducible at 3 T, providing simultaneous measurement of renal perfusion, haemodynamic parameters and tissue characteristics at baseline and during pharmacological challenge. Key points • Multiple inversion time arterial spin labelling (ASL) of the kidneys is feasible and reproducible at 3 T.• This approach allows simultaneous mapping of renal perfusion, bolus arrival time and tissue T 1 during free breathing.• This technique enables repeated measures of renal haemodynamic characteristics during pharmacological challenge.

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Section: Discussionsupporting

confidence: 84%

“…Previous work has relied on acquiring data at multiple inversion times during separate breath-holds at 3 T [20,21], or using prospective respiratory gating at 1.5 T [22,23]. The disadvantage of prospective gating is that it prolongs acquisition time unnecessarily if separation of respiratory phases is not required.…”

Section: Discussionmentioning

confidence: 99%

Motion-corrected multiparametric renal arterial spin labelling at 3 T: reproducibility and effect of vasodilator challenge

et al. 2018

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“…Continuous ASL (CASL) and pulsed ASL (PASL) are novel labeling schemes that provide better labeled magnetization deliveries and a higher SNR than previous labeling methods, without the need for an additional modified RF amplifier . Kim et al evaluated the feasibility and reproducibility of pseudocontinuous ASL (pCASL) MRI with multiple postlabeling delays (PLDs) . They found that medullar perfusion showed substantial variations that could not be used in further studies.…”

Section: Renal Fmrimentioning

confidence: 99%

“…Multiple PLDs help to compensate for the underestimation due to the partial mismatch or overestimation due to areas near large vessels. However, this correction may not be necessary in healthy populations …”

Section: Renal Fmrimentioning

confidence: 99%

Renal Functional MRI and Its Application

Zhou

Wang

Zeng

et al. 2018

Magnetic Resonance Imaging

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“…Recent studies have proposed volumetric acquisitions with spiral readouts using 3D fast/turbo spin echo (FSE/TSE) sequence for increased SNR (17). However, EPI and spiral readouts have limitations in body applications due to the association between worse off-resonance effects and larger fields of view (18). Cartesian based TSE readout using single-shot (SSFSE/SShTSE/HASTE) or segmented 3D TSE are robust options for perfusion imaging in body applications (19).…”

Section: Perfusion Imaging: Techniquesmentioning

confidence: 99%

Quantitative Methods in Abdominal MRI

Madhuranthakam

Yuan²,

Pedrosa

2017

Topics in Magnetic Resonance Imaging

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Recent improvements in arterial spin labeled (ASL) and vastly under-sampled dynamic contrast enhanced (DCE) MRI acquisitions are providing a new opportunity to explore the routine use of quantitative perfusion imaging for evaluation of a variety of abdominal diseases in clinical practice. In this review, we discuss different approaches for the acquisition and data analysis of ASL and DCE MRI techniques for quantification of tissue perfusion and present various clinical applications of these techniques in both neoplastic and non-neoplastic conditions in the abdomen.

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Measurement of arterial transit time and renal blood flow using pseudocontinuous ASL MRI with multiple post‐labeling delays: Feasibility, reproducibility, and variation

Abstract: 2 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;46:813-819.

Cited by 37 publications

References 37 publications

Motion-corrected multiparametric renal arterial spin labelling at 3 T: reproducibility and effect of vasodilator challenge

Motion-corrected multiparametric renal arterial spin labelling at 3 T: reproducibility and effect of vasodilator challenge

Renal Functional MRI and Its Application

Quantitative Methods in Abdominal MRI

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