Measles virus receptor on human T lymphocytes

Valdimarsson, H.; Agnarsdóttir, Gudrún; Lachmann, P. J.

doi:10.1038/255554a0

Cited by 91 publications

(22 citation statements)

References 6 publications

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“…This MV binding activity is destroyed by proteases, and its reexpression is inhibited by cycloheximide and tunicamycin. This strongly supports the hypothesis that MV binds to a surface glycoprotein component as has been suggested previously (Krah, 1989;Valdimarsson et al, 1975 (Yamanouchi et al, 1973). We can thus propose that the MV receptor has a wide if not ubiquitous distribution on human tissue types.…”

Section: Discussionsupporting

confidence: 76%

“…In this study, using two independent virus binding techniques, we have demonstrated that, in agreement with Valdimarsson et al (1975), MV specifically binds to human and simian cells, but not to murine cells. This MV binding activity is destroyed by proteases, and its reexpression is inhibited by cycloheximide and tunicamycin.…”

Section: Discussionmentioning

confidence: 78%

“…MV-specific attachment occurred only with human and not murine cells. We then confirmed the glycoprotein nature of the binding activity (Krah, 1989;Valdimarsson et al, 1975). We developed a monoclonal antibody (MAb) which blocked MV binding and infection of a human cell line and used it to characterize the potential receptor glycoprotein for MV further.…”

Section: Introductionmentioning

confidence: 83%

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A Monoclonal Antibody Recognizes a Human Cell Surface Glycoprotein Involved In Measles Virus Binding

Naniche

Rabourdin-Combe

et al. 1992

Journal of General Virology

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Measles virus (MV) has a very limited host range, humans being the only natural reservoir of the virus. This restriction may be due to the absence of an MV receptor on the surface of non-primate cells. We have studied the MV-binding ability of several cell lines and attempted to characterize the receptor by studying the binding of 35S-labelled MV and by a rosette formation technique. We confirmed that all the human cell lines examined (HeLa, Raji and Jurkat) bound MV and that the murine cell lines (BW and L) did not. The glycoprotein nature of the receptor activity was demonstrated by the fact that it could be removed from the cell membrane using proteolytic enzymes and by its failure to be re-expressed in the presence of a protein synthesis inhibitor or an N-glycosylation inhibitor. A monoclonal antibody isolated after immunization of mice with Raji cells specifically inhibited MV binding and infection of human cells, and recognized human and simian but not murine cells. Depending on the cell line (HeLa, Raji, Jurkat or Vero), this antibody immunoprecipitated one or two glycoproteins with apparent MrS of 57K and/or 67K from human and simian cells, but not from murine cells.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 83%

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A Monoclonal Antibody Recognizes a Human Cell Surface Glycoprotein Involved In Measles Virus Binding

Naniche

Rabourdin-Combe

et al. 1992

Journal of General Virology

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“…Of the six viruses tested, measles was the only viral antigen that induced significant suppression in normal lymphocytes. Additional experiments have indicated that the suppressive activity of measles-treated modulators is abrogated by an anti-measles serum (data not shown), and it is known that measles virus binds to human lymphocytes (33). These observations suggest that the transfer of measles is required for suppression of the responder cells.…”

Section: Discussionmentioning

confidence: 71%

Absence of virus-induced lymphocyte suppression and interferon production in multiple sclerosis

Neighbour

Bloom

1979

Proc. Natl. Acad. Sci. U.S.A.

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Lymphocytes from normal adult donors exposed in vitro to inactivated measles virus were found to exert significant suppression (33.9%) of the concanavalin A responses of cryopreserved, autochthonous responder cells. In marked contrast, lymphocytes from multiple sclerosis patients exhibited significantly reduced suppression (1.5%), and in 80% of cases failed to suppress at all. The degree of suppression increased slightly with age of the patient but did not vary with the clinical stage of disease. There was no apparent genetic restriction of suppressor activity. Although specificity of this phenomenon for measles virus has not been established, no differences in the responses of lymphocytes from normal or multiple sclerosis patient donors were found with subacute sclerosing panencephalitis, Sendai, canine distemper, mumps, or influenza viruses.Supernates of measles-treated lymphocytes from normal donors possessed both suppressive and antiviral activities. Both activities were resistant to pH 2 treatment and were neutralized by an anti-human leukocyte interferon antiserum, strongly suggesting that interferon (probably type I) was the mediator of suppression. Consistent with their inability to suppress concanavalin A responses, lymphocytes from multiple sclerosis patients failed to produce significant amounts of interferon in response to measles challenge in vitro. These results extend previous observations that multiple sclerosis patients are unable to respond appropriately to measles virus antigen in vitro. The etiology and pathogenesis of multiple sclerosis (MS), a slow neurological disease of man, remain unknown. Epidemiological and serological studies have suggested that an infectious agent might be responsible for this disease (reviewed in ref. 1). Measles virus has received perhaps the most attention as a consequence of the observation of increased measles antibodies in the sera and cerebrospinal fluids of MS patients (2) and the isolation of a measles-like virus from the brain and lymph nodes of patients with another slow neurological disease, subacute sclerosing panencephalitis (SSPE) (3,4 In the present study, we have investigated the in vitro antigen-specific induction of suppressor activity in lymphocytes from normal adult and MS patient donors, using measles virus.Our results show that, in response to measles challenge, lymphocytes from MS patients exhibit an almost total absence of suppressor activity. In addition, they fail to produce significant amounts of a soluble immunosuppressive and antiviral factor which appears to be interferon. MATERIALS AND METHODSLymphocyte Donors. Lymphocytes were separated, by Ficoll-Paque (Pharmacia) density gradient centrifugation, from 50 ml of heparinized blood drawn from the following groups of donors: normal adults (mean age, 35 yr; laboratory personnel); MS patients (mean age, 40 yr) who were diagnosed by a board-certified neurologist as having "clinically definite" MS according to the criteria of Schumacher et al. (12); patients with cerebrovascular dise...

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“…For example Jondal and Klein (17) showed that the receptor for Epstein-Barr virus was present only on B cells but not on T cells of human lymphocytes, whereas Valdimarson et al (18) reported that the receptor for measles virus was present only on T cells of human lymphocytes. McFarland (19) revealed that helper T cells but not antibody producing B cells were sensitive to the measles virus infection in mice.…”

Section: Discussionmentioning

confidence: 99%

Virus-replicating T cells in the immune response of mice. III. Role of vesicular stomatitis virus-replicating T cells in the antibody response.

Minato¹,

Katsura²

1978

The Journal of Experimental Medicine

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In the previous papers of this series (1, 2), it was shown that the antigen-reactive T cells capable of replicating vesicular stomatitis virus (VSV) ] developed in the spleen of mice after the immunization with sheep erythrocytes (SRBC). The time-course of the development of VSV-replicating T cells did not correlate with that of delayed-type hypersensitivity (DTH), helper T cells, or suppressor T cells found in the nylon wool nonadherent (NAd) population. It was also shown that VSV-replicating T cells derived from the T1 population (Raft and Cantor,

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Measles virus receptor on human T lymphocytes

Cited by 91 publications

References 6 publications

A Monoclonal Antibody Recognizes a Human Cell Surface Glycoprotein Involved In Measles Virus Binding

A Monoclonal Antibody Recognizes a Human Cell Surface Glycoprotein Involved In Measles Virus Binding

Absence of virus-induced lymphocyte suppression and interferon production in multiple sclerosis

Virus-replicating T cells in the immune response of mice. III. Role of vesicular stomatitis virus-replicating T cells in the antibody response.

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