Mean platelet volume: Should we really eye on?

Abstract

Introduction: Mean platelet volume (MPV) is a hematology analyzer generated measurement of the average size of platelets found in peripheral blood. Thrombocytopenia could be because of accelerated destruction, impaired production or abnormal pooling in spleen. Analyses of MPV values play an important role in assessing the mechanism for TCP. Material and Methods: 800 blood samples of patients with platelet count <1,50,000 ul and 800 control group samples with normal platelet count >1,50,000 ul were studied. Hematological analysis was done by Sysmex KX-21. Platelet count and MPV of all the cases and control group were noted. The cases were grouped into various categories of A, B or C depending on mechanism of decrease in platelets. Data was analyzed and tested for statistical significance using one-way ANOVA and post hoc testing using Tukey's test. Results: Majority of the cases in the present study were in group A (75.3%), followed by group B (23.9%) and group C (0.7%). A higher value of MPV (10.15±1.30 fl) was found in group A compared to other categories. Significant results of MPV were seen in group A and group B category. Conclusion: Mean platelet volume is an easily obtained platelet parameter which is helpful in delineating the various causes of TCPs. Hence an eye on the analyser readings of MPV helps in better targeted therapies.