Mean Platelet Volume: A Link Between Thrombosis and Inflammation?

Gasparyan, Armen Yuri; Ayvazyan, Lilit; Mikhailidis, Dimitri P.; Kitas, George D.

doi:10.2174/138161211795049804

Cited by 1,127 publications

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“…Furthermore, we observed an increase in MPV in ID animals. High MPV has been associated with greater thrombotic risk in a variety of conditions 34. However, ID in humans is typically associated with low MPV 35, as opposed to our model.…”

Section: Discussionmentioning

confidence: 59%

Iron deficiency alters megakaryopoiesis and platelet phenotype independent of thrombopoietin

et al. 2014

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Iron deficiency is a common cause of reactive thrombocytosis, however, the exact pathways have not been revealed. Here we aimed to study the mechanisms behind iron deficiency‐induced thrombocytosis. Within few weeks, iron‐depleted diet caused iron deficiency in young Sprague–Dawley rats, as reflected by a drop in hemoglobin, mean corpuscular volume, hepatic iron content and hepcidin mRNA in the liver. Thrombocytosis established in parallel. Moreover, platelets produced in iron deficient animals displayed a higher mean platelet volume and increased aggregation. Bone marrow studies revealed subtle alterations that are suggestive of expansion of megakaryocyte progenitors, an increase in megakaryocyte ploidy and accelerated megakaryocyte differentiation. Iron deficiency did not alter the production of hematopoietic growth factors such as thrombopoietin, interleukin 6 or interleukin 11. Megakaryocytic cell lines grown in iron‐depleted conditions exhibited reduced proliferation but increased ploidy and cell size. Our data suggest that iron deficiency increases megakaryopoietic differentiation and alters platelet phenotype without changes in megakaryocyte growth factors, specifically TPO. Iron deficiency‐induced thrombocytosis may have evolved to maintain or increase the coagulation capacity in conditions with chronic bleeding. Am. J. Hematol. 89:524–529, 2014. © 2014 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 59%

Iron deficiency alters megakaryopoiesis and platelet phenotype independent of thrombopoietin

et al. 2014

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“…Furthermore, inflammation may induce platelet activation, which increases MPV. 25 Cytokines such as interleukin-6 are a possible regulator of the increases in MPV caused by megakaryocyte ploidy. 26 Inflammatory markers such as C-reactive protein and interleukin-6 have been reported to be independently predictive of hypertension.…”

Section: Discussionmentioning

confidence: 99%

Association between mean platelet volume and hypertension incidence

Li¹,

Zhang²,

Zhu³

et al. 2017

Hypertens Res

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Mean platelet volume (MPV) is increased in various cardiovascular diseases. We sought to determine the prognostic value of MPV for hypertension. We performed a retrospective cohort study. Baseline characteristics were measured in 9168 individuals without hypertension, and the follow-up period was 9 years. Hypertension was confirmed in 2881 participants during the followup period. When the participants were grouped according to MPV quartiles, the hazard ratio of future hypertension gradually increased across the MPV quartiles. The hazard ratios of hypertension for the II, III and IV (high) vs. I (low) quartiles of MPV were 1.13 (95% confidence interval (CI) 1.01-1.25, P = 0.027), 1.25 (95% CI 1.12-1.39, Po0.001) and 1.40 (95% CI 1.26-1.55, Po0.001), respectively. In multivariate Cox regression analysis, MPV predicted hypertension independently of age, sex, platelet count, waist circumference, drinking, systolic blood pressure and creatinine levels. The present study indicated that elevated MPV is associated with increased incidence of hypertension independent of other risk factors, which suggests that platelet activity may play a role in hypertension incidence.

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“…Increased neutrophil lymphocyte ratio (N/L ratio) values and mean platelet volume (MPV) values are associated with inflammatory diseases (Gasparyan et al, 2011;Guthrie et al, 2013), whereas in the noninflammatory diseases N/L ratio values are in normal range (Olt et al, 2015).…”

Section: Introductionmentioning

confidence: 99%