Meal-induced compositional changes in blood and saliva in persons with bulimia nervosa

Abstract

There were no apparent differences in the composition of blood and saliva between bulimia nervosa and control subjects, and meal-induced compositional changes in blood were not directly mirrored in saliva composition.

Comparison of Serum and Salivary Ghrelin in Healthy Adults, Morbidly Obese, and Patients with Metastatic Carcinoma

“…These findings are in line with most of the studies which reported higher ghrelin levels in saliva compared to serum for healthy adults, epileptic patients, and patients with end-stage renal disease [2,[20][21][22]. In a study by Dynesen et al, ghrelin was found to be in the same range of concentrations in blood and saliva, both in healthy women and female patients with bulimia nervosa [17]. It has been assumed that the diffusion rate of ghrelin produced in salivary glands to saliva is probably higher than in plasma [2].…”

“…However, there are no reports about meal-induced changes of salivary ghrelin in obese individuals. In a study by Dynesen et al, salivary ghrelin concentrations were not suppressed after a standardized meal as demonstrated for serum ghrelin and did not differ significantly between healthy females and patients with bulimia nervosa [17]. By contrast, Gröschl et al showed a significant decline of both serum and saliva ghrelin 2 h after sugar load in healthy males and patients who underwent oral fructose and lactose tolerance test due to suspected carbohydrate malabsorption [11].…”

“…However, this would not explain the finding of this study for salivary ghrelin levels in morbidly obese and cancer patients unless diffusion rate from blood vessels into glandular cells would be compromised in these subjects. Dynesen et al showed that there was no correlation between ghrelin in blood and saliva in 20 healthy females and 20 women with bulimia nervosa [17]. They concluded that a direct correlation cannot be expected due to an autonomous production of ghrelin in salivary glands.…”

“…Furthermore, results of recent studies are inconsistent in terms of plasma and saliva ghrelin values, with one study reporting significant lower levels in saliva [3] and others who found higher levels for salivary ghrelin [2,16]. In addition, data regarding the correlation between blood and saliva ghrelin concentrations are also contradictory [2,16,17].…”

Miniature Direct Electron Transfer Based Enzymatic Fuel Cell Operating in Human Sweat and Saliva

“…The composition of saliva can vary significantly depending on oral health and dietary regime [22]. Closely following ingestion of food significantly higher amounts of glucose in the saliva have been observed, up to around 400 lM (from originally~30 lM) [24]. In addition to [22].…”