MDR1 gene expression and prognostic factors in primary breast carcinomas

Role of p-glycoprotein expression in predicting response to neoadjuvant chemotherapy in breast cancer-a prospective clinical study

“…The premenopausal patients have been found to have a higher p-glycoprotein expression than the postmenopausal patients [26-32]. In the present study however, there was no statistically significant correlation observed between the menopausal status and the p-glycoprotein expression.…”

“…In various studies correlation between p-glycoprotein expression and estrogen receptor status has been found to be unclear [32]. In some studies it was found that patients whose tumors lacked ER had a higher response rate to chemotherapy [26-32]. In the present study no significant correlation between the ER status and the p-glyoprotein expression could be found although the sample size was small and most of the patients were loco regionally advanced.…”

“…None, or only minimal reactivity was found in specimens coming from untreated patients (12 cases) [9]. Dixon et al , reported no clear positivity for p-glycoprotein out of 26 primary breast tumors using 219 Mab [26] and Hyun C et al , used JSB-1 MAb and detected only 6 p-glycoprotein positive tumors out of 23(26%) primary breast tumors [26]. Verrelle et al ,.…”

Role of p-glycoprotein expression in predicting response to neoadjuvant chemotherapy in breast cancer-a prospective clinical study

“…The premenopausal patients have been found to have a higher p-glycoprotein expression than the postmenopausal patients [26-32]. In the present study however, there was no statistically significant correlation observed between the menopausal status and the p-glycoprotein expression.…”

“…In various studies correlation between p-glycoprotein expression and estrogen receptor status has been found to be unclear [32]. In some studies it was found that patients whose tumors lacked ER had a higher response rate to chemotherapy [26-32]. In the present study no significant correlation between the ER status and the p-glyoprotein expression could be found although the sample size was small and most of the patients were loco regionally advanced.…”

“…None, or only minimal reactivity was found in specimens coming from untreated patients (12 cases) [9]. Dixon et al , reported no clear positivity for p-glycoprotein out of 26 primary breast tumors using 219 Mab [26] and Hyun C et al , used JSB-1 MAb and detected only 6 p-glycoprotein positive tumors out of 23(26%) primary breast tumors [26]. Verrelle et al ,.…”

Multidrug resistance gene 1 expression in salivary gland adenocarcinomas and oral squamous-cell carcinomas

“…They concluded that analyzing the expression of P-gp might play a role when planning chemotherapeutic regimens for patients with HNC and might be an additional prognostic and diagnostic tool in these patients. IC 50 and TGI values, as in another study, 50 were elevated with P-gp expression. In the present study, as in their studies, 48,49 SCC and SGA expressed P-gp.…”

ATP binding cassette transporters and drug resistance in breast cancer.

“…We found seven additional studies reporting no correlation between Pgp expression and expression of ER and/or PgR (Ro et al 1990, Wallner et al 1991, De la Torre et al 1994, He et al 1995, Brotherick et al 1996, Lacave et al 1998, Ferrero et al 2000.…”

Role of p-glycoprotein expression in predicting response to neoadjuvant chemotherapy in breast cancer-a prospective clinical study

“…The premenopausal patients have been found to have a higher p-glycoprotein expression than the postmenopausal patients [26-32]. In the present study however, there was no statistically significant correlation observed between the menopausal status and the p-glycoprotein expression.…”

“…In various studies correlation between p-glycoprotein expression and estrogen receptor status has been found to be unclear [32]. In some studies it was found that patients whose tumors lacked ER had a higher response rate to chemotherapy [26-32]. In the present study no significant correlation between the ER status and the p-glyoprotein expression could be found although the sample size was small and most of the patients were loco regionally advanced.…”

“…None, or only minimal reactivity was found in specimens coming from untreated patients (12 cases) [9]. Dixon et al , reported no clear positivity for p-glycoprotein out of 26 primary breast tumors using 219 Mab [26] and Hyun C et al , used JSB-1 MAb and detected only 6 p-glycoprotein positive tumors out of 23(26%) primary breast tumors [26]. Verrelle et al ,.…”

Multidrug resistance gene 1 expression in salivary gland adenocarcinomas and oral squamous-cell carcinomas

“…They concluded that analyzing the expression of P-gp might play a role when planning chemotherapeutic regimens for patients with HNC and might be an additional prognostic and diagnostic tool in these patients. IC 50 and TGI values, as in another study, 50 were elevated with P-gp expression. In the present study, as in their studies, 48,49 SCC and SGA expressed P-gp.…”

ATP binding cassette transporters and drug resistance in breast cancer.

“…We found seven additional studies reporting no correlation between Pgp expression and expression of ER and/or PgR (Ro et al 1990, Wallner et al 1991, De la Torre et al 1994, He et al 1995, Brotherick et al 1996, Lacave et al 1998, Ferrero et al 2000.…”

Role of p-glycoprotein expression in predicting response to neoadjuvant chemotherapy in breast cancer-a prospective clinical study

“…The premenopausal patients have been found to have a higher p-glycoprotein expression than the postmenopausal patients [26-32]. In the present study however, there was no statistically significant correlation observed between the menopausal status and the p-glycoprotein expression.…”

“…In various studies correlation between p-glycoprotein expression and estrogen receptor status has been found to be unclear [32]. In some studies it was found that patients whose tumors lacked ER had a higher response rate to chemotherapy [26-32]. In the present study no significant correlation between the ER status and the p-glyoprotein expression could be found although the sample size was small and most of the patients were loco regionally advanced.…”

“…None, or only minimal reactivity was found in specimens coming from untreated patients (12 cases) [9]. Dixon et al , reported no clear positivity for p-glycoprotein out of 26 primary breast tumors using 219 Mab [26] and Hyun C et al , used JSB-1 MAb and detected only 6 p-glycoprotein positive tumors out of 23(26%) primary breast tumors [26]. Verrelle et al ,.…”

Multidrug resistance gene 1 expression in salivary gland adenocarcinomas and oral squamous-cell carcinomas

“…They concluded that analyzing the expression of P-gp might play a role when planning chemotherapeutic regimens for patients with HNC and might be an additional prognostic and diagnostic tool in these patients. IC 50 and TGI values, as in another study, 50 were elevated with P-gp expression. In the present study, as in their studies, 48,49 SCC and SGA expressed P-gp.…”

ATP binding cassette transporters and drug resistance in breast cancer.

“…We found seven additional studies reporting no correlation between Pgp expression and expression of ER and/or PgR (Ro et al 1990, Wallner et al 1991, De la Torre et al 1994, He et al 1995, Brotherick et al 1996, Lacave et al 1998, Ferrero et al 2000.…”