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(1 citation statement)
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“…As with MDM4-S, a splicing change need not result in the expression of a novel protein in order to have a biological impact [ 31 ]. The diversion of MDM4 pre-mRNA away from the full-length isoform and toward unstable isoforms such as MDM4-S could reduce total MDM4 protein available to inhibit p53, allowing MDM4-S to lead to p53 activation.…”
Section: Discussionmentioning
confidence: 99%
“…As with MDM4-S, a splicing change need not result in the expression of a novel protein in order to have a biological impact [ 31 ]. The diversion of MDM4 pre-mRNA away from the full-length isoform and toward unstable isoforms such as MDM4-S could reduce total MDM4 protein available to inhibit p53, allowing MDM4-S to lead to p53 activation.…”
Section: Discussionmentioning
confidence: 99%