MCMV triggers ROS/NLRP3-associated inflammasome activation in the inner ear of mice and cultured spiral ganglion neurons, contributing to sensorineural hearing loss

Zhuang, W.; Wang, Caiji; Su, Xi; Qiu, Shuo; Zhang, Shili; Xu, Bing; Chen, Min; Jiang, Wen; Dong, Hongyan; Qiao, Yuehua

doi:10.3892/ijmm.2018.3539

Cited by 22 publications

(27 citation statements)

References 32 publications

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“…ROS homeostasis was associated with neurodegeneration and auditory neuropathy [ 58 ]. Three-week-old mice infected with murine congenital cytomegalovirus (MCMV) in neonatal were found to be suffering from hearing loss, and MCMV-infected cultured SGNs in vitro displayed elevated ROS levels and activated NLRP3 inflammasome, which can be suppressed by ROS inhibitor NAC [ 59 ]. Additionally, ROS is related to cochlear neuropathy in presbycusis.…”

Section: Mitochondrial Dysfunction In Auditory Neuropathymentioning

confidence: 99%

Mitochondrial Dysfunction and Therapeutic Targets in Auditory Neuropathy

et al. 2020

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Sensorineural hearing loss (SNHL) becomes an inevitable worldwide public health issue, and deafness treatment is urgently imperative; yet their current curative therapy is limited. Auditory neuropathies (AN) were proved to play a substantial role in SNHL recently, and spiral ganglion neuron (SGN) dysfunction is a dominant pathogenesis of AN. Auditory pathway is a high energy consumption system, and SGNs required sufficient mitochondria. Mitochondria are known treatment target of SNHL, but mitochondrion mechanism and pathology in SGNs are not valued. Mitochondrial dysfunction and pharmacological therapy were studied in neurodegeneration, providing new insights in mitochondrion-targeted treatment of AN. In this review, we summarized mitochondrial biological functions related to SGNs and discussed interaction between mitochondrial dysfunction and AN, as well as existing mitochondrion treatment for SNHL. Pharmaceutical exploration to protect mitochondrion dysfunction is a feasible and effective therapeutics for AN.

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Section: Mitochondrial Dysfunction In Auditory Neuropathymentioning

confidence: 99%

Mitochondrial Dysfunction and Therapeutic Targets in Auditory Neuropathy

et al. 2020

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“…ROS production started within 30 min after infection, with a peak within 2 h [ 30 ]. In host cells, ROS are quickly produced as a defence mechanism during infections caused by HSV [ 36 , 37 ], and other members of the Herpesviridae family, such as the Epstein–Barr virus [ 38 ] and cytomegalovirus [ 39 ]. During the viral infection, ROS play a pivotal role in the activation of innate immune responses.…”

Section: The Role Of Resveratrol In Hsv Infectionsmentioning

confidence: 99%

Resveratrol as a Novel Anti-Herpes Simplex Virus Nutraceutical Agent: An Overview

Annunziata

Maisto

Schisano

et al. 2018

Viruses

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The herpes simplex virus (HSV) is a common human virus affecting many people worldwide. HSV infections manifest with lesions that occur in different parts of the body, including oral, ocular, nasal, and genital skin and mucosa. In rare cases, HSV infections can be serious and lethal. Several anti-HSV drugs have been developed, but the existence of mutant viruses resistant to these drugs led to the individuation of novel antiviral agents. Plant-derived bioactive compounds, and more specifically polyphenols, have been demonstrated to exert marked anti-HSV activity and, among these, resveratrol (RSV) would be considered a good candidate. The purpose of this manuscript is to review the available literature elucidating the efficacy of RSV against HSV and the main demonstrated mechanisms of action.

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“…Histological examination showed infection, followed by a substantial loss, of the SGNs, accompanied by an infiltration of CD3+ cells and an upregulation of proinflammatory cytokines. Indeed, a prolonged inflammatory insult with high levels of IL-6, TNFα, ROS and the activation of the 'inflammasome' (Schachtele et al, 2011;Zhuang et al, 2018) may bring about the demise of the SGNs as a secondary insult rather than the primary viral infection itself, and this may be comparable to the macrophage infiltration found in the spiral ganglion region after ouabain intoxication (Brown et al, 2017).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

The use of animal models to study cell transplantation in neuropathic hearing loss

Abbas

Rivolta

2019

Hearing Research

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Auditory neuropathy (AN) is a form of sensorineural deafness specifically affecting the conduction of the nerve impulse from the cochlear hair cells to the auditory centres of the brain. As such, the condition is a potential clinical target for 'cell replacement therapy', in which a functioning auditory nerve is regenerated by transplanting an appropriated neural progenitor. In this review, we survey the current literature and examine possible experimental models for this condition, with particular reference to their compatibility as suitable hosts for transplantation. The use of exogenous neurotoxic agents such as ouabain or β-bungarotoxin is discussed, as are ageing and noise-induced synaptopathy models. Lesioning of the nerve by mechanical damage during surgery and the neuropathy resulting from infectious diseases may be very relevant clinically, and we discuss whether there are good models for these situations. We also address genetic models for AN, examining whether the phenotypes truly model the clinical situation in their human counterpart syndromes-we use the example of the hyperbilirubinaemic Gunn rat as a particular instance in this regard.

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MCMV triggers ROS/NLRP3-associated inflammasome activation in the inner ear of mice and cultured spiral ganglion neurons, contributing to sensorineural hearing loss

Cited by 22 publications

References 32 publications

Mitochondrial Dysfunction and Therapeutic Targets in Auditory Neuropathy

Mitochondrial Dysfunction and Therapeutic Targets in Auditory Neuropathy

Resveratrol as a Novel Anti-Herpes Simplex Virus Nutraceutical Agent: An Overview

The use of animal models to study cell transplantation in neuropathic hearing loss

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