J. Neurosci. Res. volume 85, issue 13, P2933-2942 2007 DOI: 10.1002/jnr.21412 View full text
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Madinyet Niyaz, Tadahiro Numakawa, Yoshinori Matsuki, Emi Kumamaru, Naoki Adachi, Hiromi Kitazawa, Hiroshi Kunugi, Motoshige Kudo

Abstract: The mechanism by which MCI-186 (3-methyl-1-phenyl-2-prazolin-5-one) exerts protective effects during cerebral infarction, other than its function as a radical scavenger, has not been fully elucidated. Here, we found that MCI-186 stimulates intracellular survival signaling in vivo and in vitro. In a rat infarction model, the infarct area was significantly smaller and the degree of edema was reduced in MCI-186-treated animals. In the MCI-186-treated rats, the number of single stranded (ss) DNA-positive damaged c…

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