Quadruple Conical Tank System (QCTS) is benchmark a laboratory setup for testing of various linear and nonlinear control algorithms for the multivariate control system. The multiple process configuration for multivariate input-output can be obtained from quadruple conical tank system. This article is concerned with designing a novel Fault-Tolerant Control (FTC) using Interval Type 2 Fuzzy Control (IT2FLC) subject to actuator and system component (Leak) faults. Additionally, paper explores the pen loop response with given operating points of quadruple conical tank system linearized model for non-minimum phase configuration obtained from MATLAB. The proposed control design method is simulated on prototype model of quadruple conical tank process for onminimum phase configuration. The performance of the proposed controller is studied through extensive simulations with regulatory and servo responses. Through comparative studies of proposed controller with other model based H ∞ , LQR, 2 DoF Decentralized PI Controller and model free Type 1 Fuzzy Logic controller (T1FLC) responses in MATLAB simulation environment, the effect of interaction, coupling, time variations and change in dynamic behaviour of QCTS confirmed.