Abstract:Accurate identification of homologs, through sequence similarity searching programs like BLAST, is central to converting genome sequence data to biological knowledge. BLAST, FASTA, and other widely used search programs use local alignments to identify homologous sequences based on shared domains, but the boundaries of local alignments reflect both the signal from homology and the intrinsic properties of the alignment scoring matrix. Reliable identification of homologous domains requires sensitive alignment met… Show more
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