2003
DOI: 10.1074/jbc.m304534200 View full text |Buy / Rent full text
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Abstract: The P2X 7 receptor, mainly expressed by immune cells, is a ionotropic receptor activated by high concentration of extracellular ATP. It is involved in several processes relevant to immunomodulation and inflammation. Among these processes, the production of extracellular interleukin-1␤ (IL-1␤), a pro-inflammatory cytokine, plays a major role in the activation of the cytokine network. We have investigated the role of P2X 7 receptor and of an associated calcium-activated potassium conductance (BK channels) in IL-… Show more

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