volume 66, issue 7, P4479-4487 1992
DOI: 10.1128/jvi.66.7.4479-4487.1992
View full text
|
|
Share
E C Jørgensen, F S Pedersen, P Jørgensen

Abstract: Type C retroviruses assemble at the plasma membrane of the infected cell. Attachment of myristic acid to the N terminus of the Gag precursor polyprotein has been shown to be essential for membrane localization and virus morphogenesis. Here, we report that the matrix (MA) protein contains regions that in conjunction with myristylation are important for Gag protein stability and the assembly of murine leukemia viruses. We identified these domains by generating a series of Akv murine leukemia virus mutants carryi…

expand abstract