Matrix metalloproteinase, hyaluronidase and elastase inhibitory potential of standardized extract of<i>Centella asiatica</i>

Nema, Neelesh K.; Maity, Niladri; Sarkar, Birendra K.; Mukherjee, Pulok K.

doi:10.3109/13880209.2013.782505

Cited by 52 publications

(34 citation statements)

References 23 publications

(22 reference statements)

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“…This is probably closely related to biologically active compounds that have been extracted from the plant. The methanol extracts of this plant showed greater inhibition activity of the analyzed enzymes than aqueous extracts [ 74 , 78 ]. As part of this work, water-glycerin extracts were analyzed, which, compared to analyses carried out by other authors, showed greater inhibition capacity than aqueous extracts, but worse than ethanol extracts.…”

Section: Resultsmentioning

confidence: 99%

Comparison of the Antiaging and Protective Properties of Plants from the Apiaceae Family

Nizioł–Łukaszewska

Zagórska‐Dziok

Ziemlewska

et al. 2020

Oxidative Medicine and Cellular Longevity

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Plant materials play a very significant role as components of products being used both for medicinal and cosmetic purposes. Due to the high content of active substances, they can play an important role as extracts with antioxidant, regenerative, and antiaging properties. The skin aging process depends on various pathological and physiological processes, among which the degradation of extracellular matrix biomolecules such as collagen and elastin, which significantly affect the maintenance of good skin condition, is very important. The secondary metabolites and plant extracts may have collagenase and elastase inhibitory activity. This activity is mainly due to the high content of a wide range of various biologically active compounds, such as polyphenols, which include, among others, flavonoids, phenolic acids, tocopherols, and tannins. The work involved a comprehensive assessment of the plant from Apiaceae family such as Meum athamanticum L., Centella asiatica L., and Aegopodium podagraria L. extract as a multifunctional raw material. During study antioxidant properties, phenolic compounds and flavonoids content, effect on collagenase and elastase enzyme activity (antiaging effect), cytotoxic properties on skin cells (keratinocytes and fibroblasts), and cell migration capacity were analyzed. It has been shown that the highest antioxidant capacity can be observed for the extract of herb of Aegopodium podagraria L. When the concentration reached 5% all tested extracts had a positive effect on the cell proliferation of both keratinocytes and fibroblasts. It turned out that the most promising inhibitor of collagenase and elastase enzymes was the extract from Aegopodium podagraria, which inhibits the activity of both enzymes by over 70% in the concentration of 5% positively affecting the condition of skin cells.

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Section: Resultsmentioning

confidence: 99%

Comparison of the Antiaging and Protective Properties of Plants from the Apiaceae Family

Nizioł–Łukaszewska

Zagórska‐Dziok

Ziemlewska

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…In addition, a decrease in skin elasticity and premature skin aging was significantly correlated with an increase in elastase and hyaluronidase. Therefore, one mechanism to inhibit aging was to reduce various enzyme activities that support matrix degradation from the abundant connective tissues in the skin (25,26).…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and Anti-Hyaluronidase Activities of Dragon Fruit Peel Extract and Kaempferol-3-O-Rutinoside

Liana

Rizal²,

Widowati

et al. 2019

JKB

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Aging is a natural process in human life and is triggered by the presence of free radicals (ROS). The use of antioxidants from natural ingredients is one of the breakthroughs to overcome aging and counteract the harmful effects caused by the free radicals. This study aimed to determine and compare the antioxidant activity of H2O2 scavenging and hyaluronidase inhibition of red dragon fruit peel extract (DFPE) and kaempferol-3-o-rutinoside (KOR) compounds. Dragon fruit peel extract (DFPE) is obtained through extraction by maceration method using 70% ethanol solvent. The design of this study included antioxidant and anti-aging activity assay of EKBN and KOR at the series concentration of 15.63; 31.25; 62.50; 125; 250; 500 µg/mL through H2O2 scavenging, as well as the DFPE and KOR hyaluronidase inhibition assay at the series concentration of 5.21; 10.42; 20.83; 41.7; 83.33; 166.67 µg/mL. EKBN shows that the average activity of H2O2 scavenging is lower than KOR. In addition, the IC50 values of KOR for H2O2 scavenging is lower (351.46±2.30ug/mL) than DFPE (409.64±23.17ug/mL). While, KOR also has higher values of inhibitory activity than of the DFPE. However, the IC50 value of KOR for hyaluronidase inhibition activity was 84.07±10.46µg/mL, equivalent to the IC50 value of DFPE (85.32±10.24µg/mL). The presence of antioxidant and anti-aging activity in the EKBN is probably caused by betalain and the KOR compound itself contained in red dragon fruit. The results of the paired-samples T-test on antioxidant activity and anti-aging of DFPE and KOR showed non-significant difference. Thus, DFPE has an equivalent antioxidant and anti-aging through H2O2 scavenging and hyaluronidase activity as possessed by the KOR compound.

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“…HA skin effects could be limited by enzymatic degradation by hyaluronidase. 28 An interesting effect of CAE is that it can inhibit the enzymatic action of hyaluronidase: Nema et al 29 have demonstrated that CAE has potent elastase, matrix metalloproteinase and hyaluronidase inhibitory effects. The hydrating serum we have evaluated in this trial contains glycerin, HA and CEA.…”

Section: Discussionmentioning

confidence: 99%

The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and <em>Centella asiatica</em> stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study

Milani¹,

Sparavigna²

2017

CCID

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IntroductionMoisturizing products are commonly used to improve hydration in skin dryness conditions. However, some topical hydrating products could have negative effects on skin barrier function. In addition, hydrating effects of moisturizers are not commonly evaluated up to 24 hours after a single application. Hyaluronic acid (HA) and glycerin are very well-known substances able to improve skin hydration. Centella asiatica extract (CAE) could exert lenitive, anti-inflammatory and reepithelialization actions. Furthermore, CAE could inhibit hyaluronidase enzyme activity, therefore prolonging the effect of HA. A fluid containing HA 1%, glycerin 5% and stem cells CAE has been recently developed (Jaluronius CS [JCS] fluid).Study aimTo evaluate and compare the 24-hour effects of JCS fluid on skin hydration and on transepidermal water loss (TEWL) in healthy subjects in comparison with the control site.Subjects and methodsTwenty healthy women, mean age 40 years, were enrolled in an intra-subject (right vs left), randomized, assessor-blinded, controlled, 1-day trial. The primary end points were the skin hydration and TEWL, evaluated at the volar surface of the forearm and in standardized conditions (temperature- and humidity-controlled room: 23°C and 30% of humidity) using a corneometer and a vapometer device at baseline, 1, 8 and 24 hours after JCS fluid application. Measurements were performed by an operator blinded for the treatments.ResultsSkin hydration after 24 hours was significantly higher (P=0.001; Mann–Whitney U test) in the JCS-treated area in comparison with the control site. JCS induced a significant (P=0.0001) increase in skin hydration at each evaluation time (+59% after 1 hour, +48% after 8 hours and +29% after 24 hours) in comparison with both baseline (P=0.0001) and non-treated control site (P=0.001). TEWL after 24 hours was significantly lower (P=0.049; Mann–Whitney U test) in the JCS-treated area in comparison with the control site (13±4 arbitrary units [AU] vs 16±6 AU). JCS fluid significantly reduced post-stripping TEWL in comparison with baseline after 1, 8 and 24 hours (−52%, −32% and −48%, respectively). In the control site, TEWL was not reduced in comparison with baseline values at each time point’s evaluation.ConclusionA single application of JCS significantly improves skin hydration for up to 24 hours at the same time as improving skin barrier function.

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Matrix metalloproteinase, hyaluronidase and elastase inhibitory potential of standardized extract ofCentella asiatica

Cited by 52 publications

References 23 publications

Comparison of the Antiaging and Protective Properties of Plants from the Apiaceae Family

Comparison of the Antiaging and Protective Properties of Plants from the Apiaceae Family

Antioxidant and Anti-Hyaluronidase Activities of Dragon Fruit Peel Extract and Kaempferol-3-O-Rutinoside

The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and <em>Centella asiatica</em> stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study

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