Matriderm® 1 mm versus Integra® Single Layer 1.3 mm for one-step closure of full thickness skin defects: a comparative experimental study in rats

Böttcher‐Haberzeth, Sophie; Biedermann, Thomas; Schiestl, Clemens; Hartmann-Fritsch, Fabienne; Schneider, Jörg J.; Ernst, Rolf; Meuli, Martin

doi:10.1007/s00383-011-2990-5

Cited by 96 publications

(66 citation statements)

References 29 publications

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“…Temporary wound coverage before autografting has been reported with a bi-layered, allogeneic skin substitute 6 . Cultured epithelial autografts applied as partially-stratified, keratinocyte sheets have been studied extensively 7,8 , but are reported to blister, ulcerate, and remain mechanically fragile due to deficient formation of basement membrane 9 . Cultured keratinocytes have also been sprayed as cell suspensions 10 over partial-thickness burns 11 , or a dermal substitute 12,13 , but the time to healing may be lengthy due to the slow organization of the cultured cell suspensions into stratified, keratinized epidermis.…”

Section: Introductionmentioning

confidence: 99%

“…Replacement of dermal tissue has also been shown to reduce long-term morbidity from scarring. Dermal substitutes from natural or engineered sources 8,14–16 have been reported to provide connective tissue beneath either epidermal autograft, or cultured keratinocytes. More recently, favorable results have been reported using a bilayered, autologous skin substitute in an initial clinical trial 17 .…”

Section: Introductionmentioning

confidence: 99%

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Randomized, Paired-Site Comparison of Autologous Engineered Skin Substitutes and Split-Thickness Skin Graft for Closure of Extensive, Full-Thickness Burns

Boyce

Simpson

Rieman

et al. 2017

Journal of Burn Care & Research

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Objectives Stable closure of full-thickness burn wounds remains a limitation to recovery from burns of greater than 50% of the total body surface area (TBSA). Hypothetically, engineered skin substitutes (ESS) consisting of autologous keratinocytes and fibroblasts attached to collagen-based scaffolds may reduce requirements for donor skin, and decrease mortality. Methods ESS were prepared from split-thickness skin biopsies collected after enrollment of 16 pediatric burn patients into an approved study protocol. ESS and split-thickness autograft (AG) were applied to 15 subjects with full-thickness burns involving a mean of 76.9% TBSA. Data consisted of photographs, tracings of donor skin and healed wounds, comparison of mortality with the National Burn Repository (NBR), correlation of TBSA closed wounds with TBSA full-thickness burn, frequencies of regrafting, and immunoreactivity to the biopolymer scaffold. Results One subject expired before ESS application, and 15 subjects received 2056 ESS grafts. The ratio of closed wound to donor areas was 108.7±9.7 for ESS compared with a maximum of 4.0±0.0 for AG. Mortality for enrolled subjects was 6.25%, and 30.3% for a comparable population from the NBR (p<0.05). Engraftment was 83.5±2.0% for ESS and 96.5±0.9 for AG. Percentage TBSA closed was 29.9±3.3% for ESS, and 47.0±2.0 for AG. These values were significantly different between the graft types. Correlation of % TBSA closed with ESS with % TBSA full-thickness burn generated an R2 value of 0.65 (p<0.001). Conclusions These results indicate that autologous ESS reduce mortality and requirements for donor skin harvesting, for grafting of full-thickness burns of greater than 50% TBSA.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Randomized, Paired-Site Comparison of Autologous Engineered Skin Substitutes and Split-Thickness Skin Graft for Closure of Extensive, Full-Thickness Burns

Boyce

Simpson

Rieman

et al. 2017

Journal of Burn Care & Research

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“…This lack of dermal tissue frequently leads to significant scarring and wound contraction due to the lack of dermal regeneration within the wound area, resulting in non-ideal outcomes regarding functionality and cosmetics [1,2,3,4]. Therefore, split-thickness skin is often used in combination with a dermal template, such as Integra artificial skin [1,3,5,6,7,8,9], Matriderm® (MedSkin Solutions Dr. Suwelack, Billerbeck, Deutschland) [4,10,11], or other collagen-elastin scaffolds [2]. …”

Section: About Denovoderm and Denovoskinmentioning

confidence: 99%

About ATMPs, SOPs and GMP: The Hurdles to Produce Novel Skin Grafts for Clinical Use

Hartmann-Fritsch

Marino

Ernst

2016

Transfus Med Hemother

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Background: The treatment of severe full-thickness skin defects represents a significant and common clinical problem worldwide. A bio-engineered autologous skin substitute would significantly reduce the problems observed with today's gold standard. Methods: Within 15 years of research, the Tissue Biology Research Unit of the University Children's Hospital Zurich has developed autologous tissue-engineered skin grafts based on collagen type I hydrogels. Those products are considered as advanced therapy medicinal products (ATMPs) and are routinely produced for clinical trials in a clean room facility following the guidelines for good manufacturing practice (GMP). This article focuses on hurdles observed for the translation of ATMPs from research into the GMP environment and clinical application. Results and Conclusion: Personalized medicine in the field of rare diseases has great potential. However, ATMPs are mainly developed and promoted by academia, hospitals, and small companies, which face many obstacles such as high financial burdens.

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“…8 In addition to burns, Integra use in congenital nevi in the trunk and extremity has been reported. 9 Integra, a bilaminar dermal regeneration template, 10 has a superficial layer composed of silicone sheeting that mimics the protective properties of the epidermis. The underlying matrix is composed of a mixture of bovine collagen and glycosaminoglycans from shark chondroitin-6-sulfate.…”

mentioning

confidence: 99%

Successful Reconstruction of Complex Pediatric Nasal Lesions

Grunwaldt

Adetayo

MacIsaac

et al. 2014

Plastic and Reconstructive Surgery Global Open

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Background:Dermal regenerate templates are currently widely used in both adult and pediatric burn reconstruction. Despite this, the safety and efficacy of regenerate templates combined with full-thickness skin grafts for the reconstruction of pediatric facial defects traditionally treated with local flaps is not widely published. The aim of this study is to report the safety and efficacy of pediatric nasal defect reconstruction using regenerative templates/full-thickness skin grafts.Methods:A retrospective review of one institution’s experience with pediatric nasal defects treated with regenerative templates was performed. All patients (n = 4) were treated with a multistage protocol. Two reviewers independently assigned Visual Analogue Cosmetic Scale (VACS) scores: 1 surgeon and 1 nonsurgical researcher not involved in patient care. Standardized photographs (anteroposterior, oblique, lateral, and worm’s eye view) were assigned VACS scores according to a 100-point scale: “abhorrent,” 0–24; “poor,” 25–49; “moderate,” 50–74; and “excellent,” 75–100. Statistical analysis was performed using Mann-Whitney U and Wilcoxon paired signed-rank tests.Results:Four patients (2 boys and 2 girls, average age 6.8 yr) who met the inclusion criteria were identified. A total of 5 nasal lesions (2 spitz nevi, 1 vascular lesion, and 2 congenital nevi) were removed. The preoperative VACS score was 45.2 (range, 5–70), compared with 84.5 (range, 45–100) postoperatively (P <0.000). There was no significant difference between raters (preoperative, P = 0.346; postoperative, P = 0.678).Conclusions:The reconstruction of complex pediatric nasal lesions using dermal regenerative templates and full-thickness postauricular skin grafts is safe and effective, and associated with low morbidity and significant improvement in VACS scores.

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Matriderm® 1 mm versus Integra® Single Layer 1.3 mm for one-step closure of full thickness skin defects: a comparative experimental study in rats

Cited by 96 publications

References 29 publications

Randomized, Paired-Site Comparison of Autologous Engineered Skin Substitutes and Split-Thickness Skin Graft for Closure of Extensive, Full-Thickness Burns

Randomized, Paired-Site Comparison of Autologous Engineered Skin Substitutes and Split-Thickness Skin Graft for Closure of Extensive, Full-Thickness Burns

About ATMPs, SOPs and GMP: The Hurdles to Produce Novel Skin Grafts for Clinical Use

Successful Reconstruction of Complex Pediatric Nasal Lesions

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