Mathematical Analysis of the Normal Anatomy of the Aging Fovea

Nesmith, Brooke L W; Gupta, Akash; Strange, Taylor; Schaal, Yuval; Schaal, Shlomit

doi:10.1167/iovs.14-15278

Cited by 17 publications

(25 citation statements)

References 23 publications

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“…Older eyes have been reported to have a sharper slope, however a preserved total volume has been reported. 29 This finding is consistent with our results because a reduced radius with a preserved maximum thickness implies a steeper slope in the foveal shape. Our data does not support differences in axial length being responsible for this observation.…”

Section: Discussionsupporting

confidence: 93%

“…28 Furthermore, it has been reported that aged fovea are more asymmetric than younger fovea. 29 In the present study, we found that none of the three measured parameters were affected by ageing, however, the radius showed a tendency to be shorter in older participants. Older eyes have been reported to have a sharper slope, however a preserved total volume has been reported.…”

Section: Discussioncontrasting

confidence: 47%

See 1 more Smart Citation

Individual Differences in Foveal Shape: Feasibility of Individual Maps Between Structure and Function Within the Macular Region

Sepulveda

Turpin

McKendrick

2016

Invest. Ophthalmol. Vis. Sci.

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Citation: Sepulveda JA, Turpin A, McKendrick AM. Individual differences in foveal shape: feasibility of individual maps between structure and function within the macular region. Invest Ophthalmol Vis Sci. 2016;57:4772-4778. DOI:10.1167/ iovs.16-19288 PURPOSE. Recently in glaucoma, different mapping schemes to combine structural and functional information within the macula have been proposed. This paper aims to investigate whether the changes in foveal shape parameters are important in the mapping between structure and function within the macular region.METHODS. Twenty younger adults (aged 24-to 33-years old) and 10 older adults (aged 62-to 76-years old) participated. On each subject, four foveally-centered radial spectral-domain optical coherence tomography (SD-OCT) scans with 458 of separation between each scan were acquired. After scan acquisition, foveal shape was extracted by fitting a previously proposed model that has been used to customize structure-function mapping in the macular region. Three parameters were obtained from the scans and then compared: the central thickness, the maximum thickness, and the radius.RESULTS. There were significant differences in the foveal shape parameters between subjects. There was no main effect of the scan axis for the central thickness; however, there was an interaction between the scan axis and maximum thickness and between the scan axis and radius. With respect to the effect of age, we did not find a main effect for the central thickness, the maximum thickness or the radius, although this parameter approached statistical significance. CONCLUSIONS.In our study, we demonstrated that the foveal shape is different for different subjects, but predictable superiorly and inferiorly within an individual. Our study highlights features important for the development of individually customized structure-function maps for the investigation of glaucomatous damage in the macular region.

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Section: Discussionsupporting

confidence: 93%

Section: Discussioncontrasting

confidence: 47%

Individual Differences in Foveal Shape: Feasibility of Individual Maps Between Structure and Function Within the Macular Region

Sepulveda

Turpin

McKendrick

2016

Invest. Ophthalmol. Vis. Sci.

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“…Only 57% of subjects performing better at detecting the direction of motion with the system ON than OFF. The clinical trial also reported improved orientation and mobility with the system, but other studies have reported the opposite, with a statistically significantly worsened performance at spatial orientation tasks with the implant turned on [147]. One reason the Argus II implant could degrade spatial orientation could be the fact that visual percepts it delivers are unrelated to direction of gaze.…”

Section: Clinical Resultsmentioning

confidence: 94%

Electronic approaches to restoration of sight

Goetz

Palanker

2016

Rep. Prog. Phys.

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Retinal prostheses are a promising means for restoring sight to patients blinded by the gradual atrophy of photoreceptors due to retinal degeneration. They are designed to reintroduce information into the visual system by electrically stimulating surviving neurons in the retina. This review outlines the concepts and technologies behind two major approaches to retinal prosthetics: epiretinal and subretinal. We describe how the visual system responds to electrical stimulation. We highlight major differences between direct encoding of the retinal output with epiretinal stimulation, and network-mediated response with subretinal stimulation. We summarize results of pre-clinical evaluation of prosthetic visual functions in- and ex-vivo, as well as the outcomes of current clinical trials of various retinal implants. We also briefly review alternative, non-electronic, approaches to restoration of sight to the blind, and conclude by suggesting some perspectives for future advancement in the field.

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“…For example, in the case of the macula, several studies and approaches have already been published in order to provide a better insight into the definition of healthy structure and shape. [1][2][3][4][5] ONH represents the part in which all retinal ganglion cell axons gather to leave the eye toward the brain. As such, investigating the ONH is central to the diagnosis of many disorders affecting the optic nerve like glaucoma, 6 idiopathic intracranial hypertension (IIH), 7,8 optic neuritis (ON), 9,10 and optic neuropathies of other etiology, for example, in the context of multiple sclerosis (MS) or neuromyelitis optica spectrum disorders (NMOSD).…”

Section: Introductionmentioning

confidence: 99%

Optic nerve head three-dimensional shape analysis

et al. 2018

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We present a method for optic nerve head (ONH) 3-D shape analysis from retinal optical coherence tomography (OCT). The possibility to noninvasively acquire in vivo high-resolution 3-D volumes of the ONH using spectral domain OCT drives the need to develop tools that quantify the shape of this structure and extract information for clinical applications. The presented method automatically generates a 3-D ONH model and then allows the computation of several 3-D parameters describing the ONH. The method starts with a high-resolution OCT volume scan as input. From this scan, the model-defining inner limiting membrane (ILM) as inner surface and the retinal pigment epithelium as outer surface are segmented, and the Bruch's membrane opening (BMO) as the model origin is detected. Based on the generated ONH model by triangulated 3-D surface reconstruction, different parameters (areas, volumes, annular surface ring, minimum distances) of different ONH regions can then be computed. Additionally, the bending energy (roughness) in the BMO region on the ILM surface and 3-D BMO-MRW surface area are computed. We show that our method is reliable and robust across a large variety of ONH topologies (specific to this structure) and present a first clinical application.

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Mathematical Analysis of the Normal Anatomy of the Aging Fovea

Cited by 17 publications

References 23 publications

Individual Differences in Foveal Shape: Feasibility of Individual Maps Between Structure and Function Within the Macular Region

Individual Differences in Foveal Shape: Feasibility of Individual Maps Between Structure and Function Within the Macular Region

Electronic approaches to restoration of sight

Optic nerve head three-dimensional shape analysis

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