Maternal Weight Management to Prevent the Developmental Programming of MAFLD in Offspring of Obese Mothers

Purcell, Amanda Renae; Glastras, Sarah J.

doi:10.3390/nu15092155

Cited by 3 publications

(1 citation statement)

References 67 publications

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“…Evidence from epidemiological, clinical, and animal studies have demonstrated that obesity affects not only maternal health, but also the long-term outcomes of offspring, with increased risk of obesity and cardiovascular disease (CVD) later in life [2][3][4]. Although the exact mechanisms of the transgenerational effect of maternal obesity remains unclear, fetal programming has been suggested to play a pivotal role in this process [5][6][7]. Human studies have provided evidence for the mechanisms underlying the link between maternal obesity and offspring cardiovascular disease.…”

Section: Introductionmentioning

confidence: 99%

Maternal Obesity and Kawasaki Disease-like Vasculitis: A New Perspective on Cardiovascular Injury and Inflammatory Response in Offspring Male Mice

Zheng,

Wang,

Huo

et al. 2023

Nutrients

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Maternal obesity affects the risk of cardiovascular disease and inflammatory response in offspring. However, the impact of maternal obesity on offspring with Kawasaki disease (KD), the leading cause of childhood acquired heart disease, is still an understudied area. This study aimed to elucidate the impact of maternal obesity on offspring in KD-like vasculitis and the underlying mechanisms. Offspring of obese female mice and normal diet dams were randomly divided into two subgroups. The pups were injected intraperitoneally with either Candida albicans water-soluble fraction (CAWS) or phosphate buffered saline (PBS) to establish the obesity (OB)-CAWS group, OB group, wild type (WT)-CAWS group, and WT group. Their weight was monitored during the study. After four weeks, echocardiography was applied to obtain the alternation of cardiac structures. Mouse cytokine panel, Hematoxylin-Eosin (HE) staining, western blot, and real-time qPCR were used to study the pathological changes and protein and RNA expression alternations. Based on the study of pathology, serology and molecular biology, maternal obesity lead to more severe vasculitis and induced altered cardiac structure in the offspring mice and promoted the expression of pro-inflammatory cytokines through activating the NF-κB signaling pathway. Maternal obesity aggravated the inflammatory response of offspring mice in KD-like vasculitis.

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Section: Introductionmentioning

confidence: 99%

Maternal Obesity and Kawasaki Disease-like Vasculitis: A New Perspective on Cardiovascular Injury and Inflammatory Response in Offspring Male Mice

Zheng,

Wang,

Huo

et al. 2023

Nutrients

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Pathological Epigenetic Events and Reversibility Review: the Intersection between Hallmarks of Aging and Developmental Origin of Health and Disease

Ruden,

Singh,

Rappolee

2023

Epigenomics

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We discuss pathological epigenetic events that are reversible (PEERs). A recent study by Poganik and colleagues showed that severe stress in mice and humans transiently elevates biological age of several tissues, and this transient age increase is reversible when the stress is removed. These studies suggest new strategies for reversing normal aging. However, it is important to note that developmental origin of health and disease studies have shown that developmental exposure to toxic chemicals such as lead causes permanent changes in neuron shape, connectivity and cellular hyperplasia of organs such as the heart and liver. In this review, the PEER hypothesis speculates that the hallmarks of aging and the hallmarks of developmental origin of health and disease intersect at PEERs.

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Pre-Pregnancy Obesity and Infants’ Motor Development within the First Twelve Months of Life: Who Is Expected to Be the Ultimate Carrier of the Obesity Burden?

Lackovic,

Nikolic,

Milicic

et al. 2024

Nutrients

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Introduction: Pre-pregnancy obesity is a significant public health concern with profound implications for maternal and child health. The burgeoning evidence suggests that maternal obesity prior to conception is intricately linked with an increased risk of gestational complications, as well as with adverse neonatal outcomes. Furthermore, the long and short-term health of offspring, including the risk of early motor development impairment, obesity, and metabolic syndrome in childhood and adulthood, may be adversely affected as well. Addressing pre-pregnancy obesity is critical for improving overall maternal and child health outcomes, and therefore, the aim of this study was to evaluate the connections linking pre-pregnancy obesity with infants’ motor development within the first twelve months of infants’ lives. Material and Methods: This study included 200 mother–infant pairs divided into two groups based on their pre-pregnancy body mass index values. To assess infants’ early motor development, we used the Alberta Infant Motor Scale (AIMS) and evaluated the parameters of infants’ early motor development at the ages of three, six, nine, and twelve months. Results: Pre-pregnancy overweight/obesity was significantly associated with excessive gestational weight gain (p < 0.001), fetal macrosomia (p = 0.022), and a family history of diabetes and cardiovascular diseases (p = 0.048 and p = 0.041, respectively), as well as with all observed parameters of early motor development at the ages of three, six, nine, and twelve months: AIMS 3 months total (p < 0.001), AIMS 6 months total (p < 0.001), AIMS 9 months total (p < 0.001), and AIMS 12 months total (p < 0.001). Furthermore, pre-pregnancy overweight/obesity was a significant predictor for AIMS 6 months total (p = 0.043) and AIMS 6 months supination (p = 0.017). Conclusions: Pre-pregnancy obesity is a critical determinant of pregnancy outcomes and offspring early motor development, with possible far-reaching implications for children’s long-term well-being. Addressing this issue requires a comprehensive approach that includes preconception weight management, targeted interventions during the pregnancy and postpartum periods, and ongoing research to better understand the underlying mechanisms and develop effective strategies for prevention and management.

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Maternal Weight Management to Prevent the Developmental Programming of MAFLD in Offspring of Obese Mothers

Cited by 3 publications

References 67 publications

Maternal Obesity and Kawasaki Disease-like Vasculitis: A New Perspective on Cardiovascular Injury and Inflammatory Response in Offspring Male Mice

Maternal Obesity and Kawasaki Disease-like Vasculitis: A New Perspective on Cardiovascular Injury and Inflammatory Response in Offspring Male Mice

Pathological Epigenetic Events and Reversibility Review: the Intersection between Hallmarks of Aging and Developmental Origin of Health and Disease

Pre-Pregnancy Obesity and Infants’ Motor Development within the First Twelve Months of Life: Who Is Expected to Be the Ultimate Carrier of the Obesity Burden?

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