Maternal vitamin D supplementation during pregnancy prevents vitamin D deficiency in the newborn: an open‐label randomized controlled trial

Rodda, Christine; Benson, Jill; Vincent, Amanda; Whitehead, Clare; Polykov, A.; Vollenhoven, Bev

doi:10.1111/cen.12762

Cited by 38 publications

(48 citation statements)

References 23 publications

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“…We observed that the cord blood serum concentration of 25(OH)D was in the range of sufficient level (>75 nmol L −1 ) in both groups, and a non‐significant difference was found between groups. Consistent with our findings, an open‐label randomized controlled trial showed that maternal vitamin D supplementation (2,000–4,000‐IU cholecalciferol) among women with VDD/insufficiency from 12 to 16 weeks of gestation until delivery prevents neonatal VDD (Rodda et al, ). It is likely that placental transportal sites, notably megalin–cubilin system, are saturated with taking a certain dose of vitamin D a day (Hollis & Wagner, ).…”

Section: Discussionsupporting

confidence: 90%

Efficacy of two different doses of oral vitamin D supplementation on inflammatory biomarkers and maternal and neonatal outcomes

Motamed

Nikooyeh

Kashanian

et al. 2019

Maternal & Child Nutrition

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Hypovitaminosis D during pregnancy is suggested to have a link with complications in both mother and infant. We aimed to evaluate the efficacy of two doses of vitamin D3 supplementation during pregnancy on maternal and cord blood vitamin D status, inflammatory biomarkers, and maternal and neonatal outcomes. A total of 84 pregnant women (gestational age of <12 weeks) were randomly allocated to one of two groups: (a) 1,000‐IU/d vitamin D and (b) 2,000 IU/d. Biochemical assessments (25‐hydroxycalciferol (25(OH)D), hs‐CRP, and cell‐culture supernatant concentrations of IL‐1β, IL‐6, and TNF‐α) of mothers were performed at the beginning and 34 weeks of gestation. Assessments of infants at delivery comprised cord blood serum concentrations of 25(OH)D, hs‐CRP, IL‐1β, IL‐6, TNF‐α, birth sizes, and Apgar score. Circulating concentrations of 25(OH)D increased in both intervention groups with more increment in 2,000 IU/d than in 1,000 IU/d (46.7 ± 30.7 vs. 24.0 ± 21.07 nmol L−1, P = .001). Concentrations of TNF‐α decreased significantly in group 2,000 (−913.1 ± 1261.3 ng L−1, P = .01). The cord blood concentration of IL‐6 in group 2,000 IU/d, compared with 1,000 IU/d, was significantly lower (25.9 ± 32.0 vs. 4.6 ± 1.4 ng L−1, P = .03). The birth sizes including weight, length, and head circumference of the infants of group 2,000 IU/d were significantly higher than the infants' of group 1,000 IU/d. Supplementation with 2,000‐IU/d vitamin D3 is more effective than 1,000 IU/d in pregnant women in terms of increasing circulating 25(OH)D, ameliorating pro‐inflammatory markers notably TNF‐α in mother and IL‐6 in cord blood, and improving neonatal outcomes including the birth sizes.

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Section: Discussionsupporting

confidence: 90%

Efficacy of two different doses of oral vitamin D supplementation on inflammatory biomarkers and maternal and neonatal outcomes

Motamed

Nikooyeh

Kashanian

et al. 2019

Maternal & Child Nutrition

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“…They concluded that vitamin D supplementation with a dose of 50,000 IU vitamin D every 2 weeks could decrease the incidence of GDM [48]. In an accordant study, Rodda et al conducted an open-label randomized controlled trial and reported the preventive effects of vitamin D supplementation in neonatal deficiency among deficient mothers [49]. …”

Section: Discussionmentioning

confidence: 99%

Rationale and Design of Khuzestan Vitamin D Deficiency Screening Program in Pregnancy: A Stratified Randomized Vitamin D Supplementation Controlled Trial

Rostami¹,

Tehrani²,

Simbar³

et al. 2017

JMIR Res Protoc

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BackgroundAlthough there have been marked improvements in our understanding of vitamin D functions in different diseases, gaps on its role during pregnancy remain. Due to the lack of consensus on the most accurate marker of vitamin D deficiency during pregnancy and the optimal level of 25-hydroxyvitamin D, 25(OH)D, for its definition, vitamin D deficiency assessment during pregnancy is a complicated process. Besides, the optimal protocol for treatment of hypovitaminosis D and its effect on maternal and neonatal outcomes are still unclear.ObjectiveThe aim of our study was to estimate the prevalence of vitamin D deficiency in the first trimester of pregnancy and to compare vitamin D screening strategy with no screening. Also, we intended to compare the effectiveness of various treatment regimens on maternal and neonatal outcomes in Masjed-Soleyman and Shushtar cities of Khuzestan province, Iran.MethodsThis was a two-phase study. First, a population-based cross-sectional study was conducted; recruiting 1600 and 900 first trimester pregnant women from health centers of Masjed-Soleyman and Shushtar, respectively, using stratified multistage cluster sampling with probability proportional to size (PPS) method. Second, to assess the effect of screening strategy on maternal and neonatal outcomes, Masjed-Soleyman participants were assigned to a screening program versus Shushtar participants who became the nonscreening arm. Within the framework of the screening regimen, an 8-arm blind randomized clinical trial was undertaken to compare the effects of various treatment protocols. A total of 800 pregnant women with vitamin D deficiency were selected using simple random sampling from the 1600 individuals of Masjed-Soleyman as interventional groups. Serum concentrations of 25(OH)D were classified as: (1) severe deficient (<10ng/ml), (2) moderate deficient (10-20ng/ml), and (3) normal status (>20ng/ml). Those with severe and moderate deficiency were randomly divided into 4 subgroups and received vitamin D3 based on protocol and were followed until delivery. Data was analyzed according to the intention-to-treat principle.ResultsRecruitment commenced in July, 2014, and as estimated, nearly 3.5 years is needed to complete the study. Results of this study will (1) provide reliable information regarding the prevalence of vitamin D deficiency during pregnancy using universal vitamin D screening approach and (2) determine the beneficial effects of universal screening and compare the various treatment protocols in terms of pregnancy outcomes.ConclusionsSince vitamin D deficiency is a prevalent disorder in pregnancy among Iranian population, this study will ensure creation of reliable evidence-based findings and will enable clinicians to better evaluate and treat vitamin D deficient pregnant women.Trial RegistrationInternational Standard Randomized Controlled Trial Number (ISRCTN): 2014102519660N1; http://www.irct.ir/searchresult.php?keyword=&id=19660&number=1&prt=7805&total=10&m=1 (Archived by WebCite at http://www.webcitation.org/6p3lk...

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“…Maternal vitamin D insufficiency from prolonged hospitalization might irreversibly affect the fetal bone metabolism, although the levels might have recovered after discharge. Recently, Rodda et al . demonstrated that supplementation of vitamin D in women with low vitamin D concentration during pregnancy increased 25(OH)D concentration in the umbilical cord blood at delivery.…”

Section: Discussionmentioning

confidence: 99%

Effect of prolonged hospitalization for threatened preterm labor on maternal and fetal vitamin D levels

Yonetani

Kaji

Hichijo

et al. 2018

J of Obstet and Gynaecol

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Maternal vitamin D supplementation during pregnancy prevents vitamin D deficiency in the newborn: an open‐label randomized controlled trial

Abstract: Vitamin D supplementation of vitamin D deficient pregnant women prevents neonatal vitamin D deficiency.

Cited by 38 publications

References 23 publications

Efficacy of two different doses of oral vitamin D supplementation on inflammatory biomarkers and maternal and neonatal outcomes

Efficacy of two different doses of oral vitamin D supplementation on inflammatory biomarkers and maternal and neonatal outcomes

Rationale and Design of Khuzestan Vitamin D Deficiency Screening Program in Pregnancy: A Stratified Randomized Vitamin D Supplementation Controlled Trial

Effect of prolonged hospitalization for threatened preterm labor on maternal and fetal vitamin D levels

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