Maternal Vaccination and Risk of Hospitalization for Covid-19 Among Infants

Halasa, Natasha; Olson, Samantha M; Staat, Mary Allen; Newhams, Margaret M; Price, Ashley M; Pannaraj, Pia S.; Boom, Julie A.; Sahni, Leila C; Chiotos, Kathleen; Cameron, Melissa A; Bline, Katherine; Hobbs, Charlotte V.; Maddux, Aline B; Coates, Bria M.; Michelson, Kelly; Heidemann, Sabrina M.; Irby, Katherine; Nofziger, Ryan A; Mack, Elizabeth H.; Smallcomb, Laura; Schwartz, Stephanie P; Walker, Tracie C; Gertz, Shira J.; Schuster, Jennifer E; Kamidani, Satoshi; Tarquinio, Keiko M.; Bhumbra, Samina; Maamari, Mia; Hume, Janet R.; Crandall, Hillary; Levy, Emily R.; Zinter, Matt S; Bradford, Tamara T; Flori, Heidi R.; Cullimore, Melissa L; Kong, Michele; Cvijanovich, Natalie Z.; Gilboa, Suzanne M.; Polen, Kara; Campbell, Angela P; Randolph, Adrienne G.; Patel, Manish

doi:10.1097/01.ogx.0000912568.67045.6f

Cited by 3 publications

(9 citation statements)

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“…1). [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] Of the 15 studies, 2 case-control studies and 13 cohort studies reported on 90443 vaccinated pregnant women and 265063 unvaccinated pregnant women. The included studies reported data from six countries: Israel, UK, Romania, Canada, US, Sweden, and Norway (Table 1).…”

Section: Search Results and Basic Characteristicsmentioning

confidence: 99%

“…Recently, several studies about neonatal and early infant outcomes after maternal COVID-19 vaccination have already received increasing attention. [12][13][14][15][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] However, a comprehensive meta-analysis of neonatal outcomes after maternal COVID-19 vaccination is still lacking. Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Of the 15 studies, 11 studies reported COVID-19 vaccination during pregnancy on preterm as a neonatal outcome, involving 38,181 vaccinated pregnant women and 56,246 unvaccinated pregnant women. 22,23,25,26,[28][29][30][31][33][34][35] The pooled OR (95% CI) was 0.83 (0.74, 0.95), with an overall effect P = 0.004. I 2 = 55% (Fig.…”

Section: Meta-analysis Of Main Neonatal Outcomesmentioning

confidence: 96%

“…28,29 More and more data have showed benefits of COVID-19 vaccination outweigh the risks during pregnancy. [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] In return, professional recommendation based on these data could contribute to relieve pregnant women's concerns on vaccination. By now, the American College of Obstetricians and Gynecologists, European Board and College of Obstetrics and Gynecology, Israel Ministry of Health and so on have already recommended pregnant receive a COVID-19 vaccine.…”

Section: Odds Ratio M-h Fixedmentioning

confidence: 99%

“…20,21 Nevertheless, several individual observational studies exploring the effects of COVID-19 vaccines on pregnancy and perinatal outcomes have included preterm birth, small for gestation (SGA), NICU admission and so on for neonatal outcomes. [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] Due to the importance of neonatal outcomes after maternal pregnancy, there is an immediate need for a systematic review and meta-analysis of published data to clarify differences in neonatal outcomes between COVID-19 vaccination during pregnancy and unvaccination during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

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Systematic review and meta-analysis of neonatal outcomes of COVID-19 vaccination in pregnancy

et al. 2023

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Background The safety of coronavirus disease 2019 (COVID-19) vaccines during pregnancy is a particular concern. Here, we addressed the neonatal outcomes after maternal vaccination of COVID-19 during pregnancy. Methods We systematically searched PubMed, EMBASE, and the WHO COVID-19 Database for studies on neonatal outcomes after maternal COVID-19 vaccination from inception to 3 July 2022. Main neonatal outcomes were related to preterm, small for gestation (SGA), NICU admission, low Apgar score at 5 min (<7), and additional neonatal outcomes such as gestation <34 weeks, low birth weight and some neonatal morbidity were all also analyzed. Results A total of 15 studies were included. We found that maternal vaccination during pregnancy was related to the reduction rates of Preterm, SGA, Low Apgar score at 5 min (<7). In addition, there was no evidence of a higher risk of adverse neonatal outcomes after maternal vaccination of COVID-19 during pregnancy, including NICU admission, preterm birth with gestation <34 weeks, low birth weight, very low birth weight, congenital anomalies, and so on. Conclusions COVID-19 vaccination in pregnant women does not raise significant adverse effects on neonatal outcomes and is related to a protective effect on some neonatal outcomes. Impact Present study has addressed the neonatal outcomes after maternal vaccination of COVID-19 during pregnancy. COVID-19 vaccination in pregnant women does not raise significant adverse effects on neonatal outcomes and is related to a protective effect on some neonatal outcomes. The present study could encourage pregnant women to be vaccinated against COVID-19.

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Section: Search Results and Basic Characteristicsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Meta-analysis Of Main Neonatal Outcomesmentioning

confidence: 96%

Section: Odds Ratio M-h Fixedmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Systematic review and meta-analysis of neonatal outcomes of COVID-19 vaccination in pregnancy

et al. 2023

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Transplacental transmission of SARS‐CoV‐2 immunoglobulin G antibody to infants from maternal COVID‐19 vaccine immunization before pregnancy

Yang

Xing

Zhao

2022

Journal of Medical Virology

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The coronavirus disease 2019 (COVID‐19) vaccine generates functional antibodies in maternal circulation that are detectable in infants, while the information is restricted to the usage of COVID‐19 vaccine during pregnancy. In this study, we aimed to evaluate the effect of maternal COVID‐19 vaccines before pregnancy. Infants were included from mothers with no inactivated COVID‐19 vaccine, 1‐, 2‐, and 3‐dose before pregnancy, and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) immunoglobulin G (IgG) antibodies were tested. Comparative analysis was done between the groups. A total of 130 infants were enrolled in the study. Significantly higher levels of SARS‐CoV‐2 IgG antibodies in infants born to mothers with 3‐dose COVID‐19 vaccine before pregnancy compared with 1‐ and 2‐dose groups (p < 0.0001). The levels of antibodies decreased significantly with age in infants born to mothers with the 3‐dose COVID‐19 vaccine before pregnancy (r = −0.338, p = 0.035), and it was still higher than that 2‐dose COVID‐19 vaccine group. The maternal SARS‐CoV‐2 antibodies produced from the inactivated COVID‐19 vaccine before pregnancy can be transferred to newborns via the placenta. Maternal immunization with 3‐dose of the COVID‐19 vaccine before pregnancy could be more beneficial for both mothers and infants.

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Maternal and cord blood BAFF and APRIL levels during pregnancy

Stohl

2022

American J Rep Immunol

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Problem: Dysregulation of factors vital to the survival B cells and/or plasma cells, such as BAFF and APRIL, could be detrimental to a pregnancy. Method of Study:Serially collected first-, second-, and third-trimester serum samples were measured for BAFF and APRIL by ELISA from 150 pregnant women (71 healthy + 79 with a chronic medical disease) at a single medical center. Postpartum serum samples were also collected from the majority of these women. Matched thirdtrimester and cord blood samples were collected from 168 women (86 healthy + 82 with a chronic medical disease). Data were analyzed by chi-square statistic, unpaired ttest, paired t-test, Mann-Whitney rank sum test, Wilcoxon signed rank test, Spearman rank order correlation, and receiver operator characteristic (ROC) curve analyses as appropriate.Results: Maternal serum BAFF levels declined as the pregnancies progressed and rebounded postpartum, whereas serum APRIL levels remained relatively flat throughout pregnancy and postpartum. Cord BAFF and APRIL levels correlated positively with gestation age and were considerably greater than the corresponding maternal third-trimester serum BAFF and APRIL levels, respectively. In women who developed preeclampsia, third-trimester BAFF levels were greater, rather than lower, than their corresponding second-trimester BAFF levels. ROC curve analysis suggested a potential role for third-trimester serum BAFF level as a biomarker of preeclampsia.Conclusions: BAFF and APRIL are differentially regulated in the mother during and following pregnancy, whereas each is upregulated in the developing fetus. An increase in third-trimester serum BAFF level may portend development of preeclampsia.

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Maternal Vaccination and Risk of Hospitalization for Covid-19 Among Infants

Cited by 3 publications

References 0 publications

Systematic review and meta-analysis of neonatal outcomes of COVID-19 vaccination in pregnancy

Systematic review and meta-analysis of neonatal outcomes of COVID-19 vaccination in pregnancy

Transplacental transmission of SARS‐CoV‐2 immunoglobulin G antibody to infants from maternal COVID‐19 vaccine immunization before pregnancy

Maternal and cord blood BAFF and APRIL levels during pregnancy

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