Maternal Type 1 diabetes activates stress response in early placenta

Gauster, Martin; Majali‐Martinez, Alejandro; Maninger, Sabine; Gutschi, Elisabeth; Greimel, Patrick; Ivanišević, Marina; Djelmiš, Josip; Desoyé, Gernot; Hiden, Ursula

doi:10.1016/j.placenta.2017.01.118

Cited by 31 publications

(15 citation statements)

References 41 publications

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“…Lactate is not only an energy source during preimplantation development, it is also a strong cytosolic reductant, via the activity of lactate dehydrogenase [26]. It alleviates the harmful effects of increased oxidative stress which has been described in diabetic pregnancies [27,28]. of sorbitol.…”

Section: Maternal Diabetes Mellitus Increases Glycolysis and Pentose mentioning

confidence: 99%

Metabolic Profiling in Blastocoel Fluid and Blood Plasma of Diabetic Rabbits

Schindler

Pendzialek

Grybel

et al. 2020

IJMS

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Metabolic disorders of the mother adversely affect early embryo development, causing changes in maternal metabolism and consequent alterations in the embryo environment in the uterus. The goal of this study was to analyse the biochemical profiles of embryonic fluids and blood plasma of rabbits with and without insulin-dependent diabetes mellitus (DT1), to identify metabolic changes associated with maternal diabetes mellitus in early pregnancy. Insulin-dependent diabetes was induced by alloxan treatment in female rabbits 10 days before mating. On day 6 post-coitum, plasma and blastocoel fluid (BF) were analysed by ultrahigh performance liquid chromatography-tandem mass spectroscopy (UPLC-MS/MS) (Metabolon Inc. Durham, NC, USA). Metabolic datasets comprised a total of 284 and 597 compounds of known identity in BF and plasma, respectively. Diabetes mellitus had profound effects on maternal and embryonic metabolic profiles, with almost half of the metabolites changed. As predicted, we observed an increase in glucose and a decrease in 1,5-anhydroglucitol in diabetic plasma samples. In plasma, fructose, mannose, and sorbitol were elevated in the diabetic group, which may be a way of dealing with excess glucose. In BF, metabolites of the pentose metabolism were especially increased, indicating the need for ribose-based compounds relevant to DNA and RNA metabolism at this very early stage of embryo development. Other changes were more consistent between BF and plasma. Both displayed elevated acylcarnitines, body3-hydroxybutyrate, and multiple compounds within the branched chain amino acid metabolism pathway, suggesting that lipid beta-oxidation is occurring at elevated levels in the diabetic group. This study demonstrates that maternal and embryonic metabolism are closely related. Maternal diabetes mellitus profoundly alters the metabolic profile of the preimplantation embryo with changes in all subclasses of metabolites.

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Section: Maternal Diabetes Mellitus Increases Glycolysis and Pentose mentioning

confidence: 99%

Metabolic Profiling in Blastocoel Fluid and Blood Plasma of Diabetic Rabbits

Schindler

Pendzialek

Grybel

et al. 2020

IJMS

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“…Studies have shown that hyperglycemia adversely effects placental development [9,10], and the placenta of a diabetic mother is more likely to enter a state of oxidative stress by the first trimester, a precursor to the development of preeclampsia [11,12]. Maternal obesity is also connected with abnormal placental development [13], including a higher risk of preeclampsia [14] and severe maternal morbidity (SMM) [15].…”

Section: Introductionmentioning

confidence: 99%

Risk of severe maternal morbidity or death in relation to elevated hemoglobin A1c preconception, and in early pregnancy: A population-based cohort study

et al. 2020

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BackgroundThe relation between prepregnancy average glucose concentration and a woman's risk of severe maternal morbidity (SMM) is unknown. The current study evaluated whether an elevated preconception hemoglobin A1c (A1c) is associated with SMM or maternal death among women with and without known prepregnancy diabetes mellitus (DM). Methods and findingsA population-based cohort study was completed in Ontario, Canada, where there is universal healthcare. The main cohort included 31,225 women aged 16-50 years with a hospital live birth or stillbirth from 2007 to 2015, and who had an A1c measured within 90 days before conception, including 28,075 women (90%) without known prepregnancy DM. The main outcome was SMM or maternal mortality from 23 weeks' gestation up to 42 days postpartum. Relative risks (RRs) were generated using modified Poisson regression, adjusting for the main covariates of maternal age, multifetal pregnancy, world region of origin, and tobacco/ drug dependence. The mean maternal age was 31.1 years. Overall, SMM or death arose among 682 births (2.2%). The RR of SMM or death was 1.16 (95% CI 1.14-1.19; p < 0.001) per 0.5% increase in A1c and 1.16 (95% CI 1.13-1.18; p < 0.001) after adjusting for the main covariates. The adjusted relative risk (aRR) was increased among those with (1.11, 95% CI 1.07-1.14; p < 0.001) and without (1.15, 95% CI 1.02-1.29; p < 0.001) known prepregnancy diabetes, and upon further adjusting for body mass index (BMI) (1.15, 95% CI 1.11-1.20; p < 0.001), or chronic hypertension and prepregnancy serum creatinine (1.11, 95% CI 1.04-1.18; p = 0.002). The aRR of SMM or death was 1.31 (95% CI 1.06-1.62; p = 0.01) in those with a preconception A1c of 5.8%-6.4%, and 2.84 (95% CI 2.31-3.49; p <

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“…Moreover, HSP may play a role in mediating the effect of diabetes during pregnancy ( Skórzyńska-Dziduszko et al, 2018 ). The elevated levels of HSP70 in the first trimester placental tissues of DM women as compared to normal pregnant women suggest the involvement of HSP in diabetes-associated pregnancy complications ( Gauster et al, 2017 ). In a patient-based study, it was found that release of HSP72 in response to glucose challenge in non-obese black women is an intrinsic mechanism to regulate insulin production and also to protect the mother and fetus from hyperglycemia or hyperinsulinemia ( Jaffe et al, 2013 ).…”

Section: Heat Shock Proteins In Placentationmentioning

confidence: 99%

Heat Shock Proteins and Their Role in Pregnancy: Redefining the Function of “Old Rum in a New Bottle”

Jee

Dhar

Singh

et al. 2021

Front. Cell Dev. Biol.

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Pregnancy in humans is a multi-step complex physiological process comprising three discrete events, decidualization, implantation and placentation. Its overall success depends on the incremental advantage that each of the preceding stages passes on to the next. The success of these synchronized sequels of events is an outcome of timely coordination between them. The pregnancy events are coordinated and governed primarily by the ovarian steroid hormones, estrogen and progesterone, which are essentially ligand-activated transcription factors. It’s well known that intercellular signaling of steroid hormones engages a plethora of adapter proteins that participate in executing the biological functions. This involves binding of the hormone receptor complex to the DNA response elements in a sequence specific manner. Working with Drosophila melanogaster, the heat shock proteins (HSPs) were originally described by Ferruccio Ritossa back in the early 1960s. Over the years, there has been considerable advancement of our understanding of these conserved families of proteins, particularly in pregnancy. Accumulating evidence suggests that endometrial and uterine cells have an abundance of HSP27, HSP60, HSP70 and HSP90, implying their possible involvement during the pregnancy process. HSPs have been found to be associated with decidualization, implantation and placentation, with their dysregulation associated with implantation failure, pregnancy loss and other feto-maternal complications. Furthermore, HSP is also associated with stress response, specifically in modulating the ER stress, a critical determinant for reproductive success. Recent advances suggest a therapeutic role of HSPs proteins in improving the pregnancy outcome. In this review, we summarized our latest understanding of the role of different members of the HSP families during pregnancy and associated complications based on experimental and clinical evidences, thereby redefining and exploring their novel function with new perspective, beyond their prototype role as molecular chaperones.

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Maternal Type 1 diabetes activates stress response in early placenta

Cited by 31 publications

References 41 publications

Metabolic Profiling in Blastocoel Fluid and Blood Plasma of Diabetic Rabbits

Metabolic Profiling in Blastocoel Fluid and Blood Plasma of Diabetic Rabbits

Risk of severe maternal morbidity or death in relation to elevated hemoglobin A1c preconception, and in early pregnancy: A population-based cohort study

Heat Shock Proteins and Their Role in Pregnancy: Redefining the Function of “Old Rum in a New Bottle”

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