Maternal serum progesterone level in preeclampsia

Chowdhury, Shiuly; Ferdous, Jannatul; Nahar, K; Mahmood, Sharmeen

doi:10.3329/bsmmuj.v13i1.45052

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…Progesterone is primarily produced by the placenta after the eighth week of gestation (Pylypchuk and Pylypchuk 2021 ), and the abundant immuno-expression of P and PRs in normotensive placental tissue is expected. The decrease of P observed in our study is corroborated by several studies that noted lower circulating levels of P in PE, suggesting a hormonal deficiency in PE (Iou et al 2005 ; Kiprono et al 2013 ; Wan et al 2018 ; Chowdhury et al 2020 ).…”

Section: Discussionsupporting

confidence: 90%

Placental progesterone and its receptor in HIV-infected pre-eclamptic women

Sewnarain,

Singh,

Naicker

2023

Histochem Cell Biol

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Given the high prevalence of HIV infection and pre-eclampsia (PE) in South Africa, this study evaluated and compared the placental immunostaining of progesterone (P) and progesterone receptors (PR) in the synergy of HIV-infected PE compared to normotensive pregnant women using immunohistochemistry interfaced with morphometric image analysis. Progesterone immunostaining was expressed widely across exchange and conducting villi within mesenchymal, endothelial, and trophoblast cells. In contrast, PR was expressed within syncytiotrophoblasts and was absent within endothelial cells. In exchange villi, P and PR immuno-expression was significantly lower in PE compared to the normotensive group (p = < 0.0001 and p = < 0.0001, respectively) and within the early-onset pre-eclampsia (EOPE) compared to the late-onset pre-eclampsia (LOPE) group (p = < 0.0001 and p = < 0.0001, respectively). Progesterone immuno-expression was significantly lower in the HIV+ compared to the HIV− group (p = < 0.0001), whilst PR was non-significant. In conducting villi, P and PR immuno-expression was significantly lower in the EOPE compared to the LOPE group (p = < 0.0001 and p = < 0.0001, respectively) and in the HIV+ compared to the HIV− group (p = < 0.0001 and p = 0.0009, respectively). Progesterone immuno-expression was slightly higher in the PE compared to normotensive group, and PR immuno-expression was non-significant. There was a significant difference between P and PR within exchange versus conducting villi regardless of pregnancy type, with villi type accounting for 34.47% and 15.28% of total variance for P and PR, respectively. Placental P and PR immuno-expression is downregulated in the duality of PE and HIV+ infection. The use of combined antiretroviral therapy (cART) may result in defective P synthesis, which causes insufficient binding to its receptors. Consequently, PI3K/AKT, JAK-STAT, and MAPK signalling pathways are affected, impairing trophoblast invasion and leading to pre-eclampsia development. Notably, the decrease in P and PR immuno-expression in EOPE validates their effect on placentation.

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Section: Discussionsupporting

confidence: 90%

Placental progesterone and its receptor in HIV-infected pre-eclamptic women

Sewnarain,

Singh,

Naicker

2023

Histochem Cell Biol

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“…Data analysis revealed no statistically significant difference between two groups patients in terms of sociodemographic parameters (p>0.05) but about 80% patients both case and controlled group come from lower and lower middle class family. In accordance with Chowdhury et al [15] reported the mean age and socioeconomic condition of the participants with or without preeclampsia were 27.1±5.2 years and 25.8±4.5 years, respectively (p=0.271) and 53.3 and 72.9% belonged to the middle class. The body mass index of 46.7% from the experimental group and 41.7% from the control group were ≥25 kg/m2, respectively.…”

Section: Discussionsupporting

confidence: 86%

Association of serum free testosterone with preeclampsia

Siddika,

Akthar,

Urmee

et al. 2024

Int. J. Clin. Obstet. Gynaecol.

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Background: Preeclampsia is a pregnancy specific disorder characterized by hypertension and proteinuria or new onset of hypertension and significant end organ disfunction with or without proteinuria after 20 weeks of gestation. Preeclampsia is associated with reduction of utero-placental blood flow, which is reflected in high blood pressure and proteinuria during the second half of pregnancy. Hyper-androgenism may be implicated in the pathogenesis of preeclampsia, if so, there should be a difference between the levels of testosterone in pregnant women complicated with preeclampsia and those without this complication.Objective: To determine association of serum free testosterone with preeclampsia. Methods: This case control study was conducted in the department of Obstetrics & Gynaecology of Institute of Child & Mother Health (ICMH), Matuail, Dhaka during September 2021 to August 2022. Patient complicated by preeclampsia and patient without preeclampsia attending Obstetrics and Gynecology Department was included in this study by consecutive sampling. All of them were briefed regarding the study. After that they were included by eligibility criteria and patients were classified into two groups. A total of 80 participants during second half of pregnancy were enrolled and among them 40 patient complicated by preeclampsia was considered as case and 40 patients without preeclampsia was considered as control. A written consent was obtained. Data were analysed by using Statistical Packages for Social Sciences (SPSS-26). The significance test was done by unpaired t test and Chi square test. P value less than 0.05 was considered statistically significant. Results: The mean age of the cases was 23.6±3.66 years and the mean age of the control was 24.25±4.91 years. In both group maximum study subjects were secondary education 40% and 45% in case and control group respectively. Maximum patients 52.5% and 42.5% were 31-35 gestational weeks in case and control group respectively. The mean gestational age 32.1±2.92 weeks in preeclamptic group and 32.4±3.53 weeks in control group. Data analysis revealed no statistically significant difference between two groups patients in terms of sociodemographic parameters (p>0.05). The mean free serum testosterone was 2.91±0.62 in preeclampsia group and 1.19±0.49 in healthy normal pregnancy group. Analysis revealed that mean free serum testosterone was significantly increased among the preeclampsia group than the healthy normal pregnancy group (p<0.001). It was confirmed that the serum free testosterone levels were considerably high in the preeclamptic participants than the participants without preeclampsia. Conclusion:The levels of free testosterone is higher in patients with preeclampsia compared to normotensive pregnant women during the second half of pregnancy. This difference could indicate an involvement of testosterone in the pathophysiology of preeclampsia and stimulates research in the potential role of anti-androgens in the management of preeclampsia.

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“…In 2020, also in Bangladesh, another study conducted by Chowdhury et al found significantly higher fT levels in pre-eclamptic women by the end of gestation when compared to the control [ 92 ]. During the same year, in Taiwan, Lan’s research group discovered similar T levels in the umbilical cords of both groups.…”

Section: Effects Of Testosterone In Pre-eclampsiamentioning

confidence: 99%

Relationship between Androgens and Vascular and Placental Function during Pre-eclampsia

Fernandes,

Lorigo,

Cairrao

2024

CIMB

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Hypertensive disorders of pregnancy (HDP) represent a substantial risk to maternal and fetal health. Emerging evidence suggests an association between testosterone and pre-eclampsia (PE), potentially mediated through androgen receptors (AR). Nevertheless, the mechanism driving this association is yet to be elucidated. On the other hand, reports of transgender men’s pregnancies offer a limited and insightful opportunity to understand the role of high androgen levels in the development of HDP. In this sense, a literature review was performed from a little over 2 decades (1998–2022) to address the association of testosterone levels with the development of HDP. Furthermore, this review addresses the case of transgender men for the first time. The main in vitro outcomes reveal placenta samples with greater AR mRNA expression. Moreover, ex vivo studies show that testosterone-induced vasorelaxation impairment promotes hypertension. Epidemiological data point to greater testosterone levels in blood samples during PE. Studies with transgender men allow us to infer that exogenous testosterone administration can be considered a risk factor for PE and that the administration of testosterone does not affect fetal development. Overall, all studies analyzed suggested that high testosterone levels are associated with PE.

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Maternal serum progesterone level in preeclampsia

Abstract: a

Cited by 4 publications

References 12 publications

Placental progesterone and its receptor in HIV-infected pre-eclamptic women

Placental progesterone and its receptor in HIV-infected pre-eclamptic women

Association of serum free testosterone with preeclampsia

Relationship between Androgens and Vascular and Placental Function during Pre-eclampsia

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