Maternal serum PFOA concentration and DNA methylation in cord blood: A pilot study

Kingsley, Samantha L.; Kelsey, Karl T.; Butler, Rondi A.; Chen, Aimin; Eliot, Melissa; Romano, Megan E.; Houseman, Andres; Koestler, Devin C.; Lanphear, Bruce P.; Yolton, Kimberly; Braun, Joseph M.

doi:10.1016/j.envres.2017.06.013

Cited by 29 publications

(17 citation statements)

References 22 publications

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“…32 Moreover, in a pilot study among HOME Study participants, maternal serum PFOA concentrations were positively associated with neonatal peripheral leukocyte DNA methylation patterns; leptin receptor and promoter genes were not among the top 20 genes that differed by maternal serum PFOA concentrations. 33 In a recent study, newborn PFOS concentrations were associated with an increase in reactive oxygen species concentrations. 34 In vitro studies also report that some perfluoroalkyl substances can affect the action of hydroxysteroid dehydrogenases, which may in turn increase cortisol concentrations to adversely affect fetal growth.…”

Section: Discussionmentioning

confidence: 94%

Prenatal exposure to perfluoroalkyl substances and adipocytokines: the HOME Study

et al. 2018

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Section: Discussionmentioning

confidence: 94%

Prenatal exposure to perfluoroalkyl substances and adipocytokines: the HOME Study

et al. 2018

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“…Similarly, Kingsley and colleagues examined a cohort of 44 mother-child pairs and reported no correlation between PFOA exposure during pregnancy and global DNA methylation in offspring cord blood but identified 20 PFOA specific differentially methylated CpG sites in genes involved in cell growth [74]. In males in a Faroese birth cohort, PFOS exposure was associated with changes in thousands of differentially methylated regions, especially for genes involved in embryonic growth and development [75].…”

Section: Induces Epigenetic Alterationsmentioning

confidence: 99%

“…Animal Bioassay In Vitro PFOA Association: [70]; [72]; [73]; [74] No association: [71]; [82]; [76] Association: [78] Long-chain PFAS a,b PFOS Association: [71]; [73]; [82] No association: [70]; [76] Association: [77] Association: [79]; [81] No association: […”

Section: Epidemiologicalmentioning

confidence: 99%

Application of the Key Characteristics of Carcinogens to Per and Polyfluoroalkyl Substances

Temkin

Hocevar

Andrews

et al. 2020

IJERPH

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Per- and polyfluoroalkyl substances (PFAS) constitute a large class of environmentally persistent chemicals used in industrial and consumer products. Human exposure to PFAS is extensive, and PFAS contamination has been reported in drinking water and food supplies as well as in the serum of nearly all people. The most well-studied member of the PFAS class, perfluorooctanoic acid (PFOA), induces tumors in animal bioassays and has been associated with elevated risk of cancer in human populations. GenX, one of the PFOA replacement chemicals, induces tumors in animal bioassays as well. Using the Key Characteristics of Carcinogens framework for cancer hazard identification, we considered the existing epidemiological, toxicological and mechanistic data for 26 different PFAS. We found strong evidence that multiple PFAS induce oxidative stress, are immunosuppressive, and modulate receptor-mediated effects. We also found suggestive evidence indicating that some PFAS can induce epigenetic alterations and influence cell proliferation. Experimental data indicate that PFAS are not genotoxic and generally do not undergo metabolic activation. Data are currently insufficient to assess whether any PFAS promote chronic inflammation, cellular immortalization or alter DNA repair. While more research is needed to address data gaps, evidence exists that several PFAS exhibit one or more of the key characteristics of carcinogens.

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“…In addition, we are able to derive sleep measures from the actigraphy data. 55 56 Other biomarkers We measured other biomarkers including leucocyte DNA methylation, 57 high-resolution metabolomics, 58 gonadal hormone concentrations and vitamin D metabolite concentrations. We also conducted a drug screen on children's urine using a clinical drug panel assay.…”

Section: Physical Activity Diet and Sleepmentioning

confidence: 99%

Adolescent follow-up in the Health Outcomes and Measures of the Environment (HOME) Study: cohort profile

et al. 2020

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PurposeEnvironmental chemical exposures may adversely affect an array of adolescent health outcomes. Thus, we used the Health Outcomes and Measures of the Environment (HOME) study, a prospective cohort that recruited pregnant women and conducted longitudinal follow-up on children over the first 12 years of life, to determine if and when chemical exposures affect adolescent health.ParticipantsWe recruited 468 pregnant women (age range: 18–45 years) from the Cincinnati, Ohio region to participate in a cohort study between March 2003 and January 2006. Follow-up included two clinic and one home visits during pregnancy, a delivery hospital visit, and four home and six clinic visits when children were aged 4 weeks and 1, 2, 3, 4, 5 and 8 years. Of 441 children available for follow-up, 396 (90%) completed at least one follow-up and 256 (58%) completed the most recent follow-up at 12 years of age (range: 11–14).Findings to dateOur new measures include maternal/child report of internalising symptoms, neuroimaging, dual-energy X-ray absorptiometry-derived estimates of lean/adipose tissue and bone mineral density, and cardiometabolic risk biomarkers. We assessed adolescent exposure to perfluoroalkyl substances, phenols, phthalates and flame retardants. Participants completing follow-up at 12 years of age were similar to the original cohort in terms of baseline factors. Most children had typical and expected values for this age on measures of internalising symptoms, body composition, bone density and cardiometabolic risk markers. Notably, 36% and 11% of children had scores indicative of potential anxiety and depressive disorders, respectively. Approximately 35% of children were overweight or obese, with higher prevalence among girls. Thirty-three per cent of children had borderline or high triglyceride concentrations (>90 mg/dL).Future plansWe will examine associations of early life environmental chemical exposures with adolescent health measures while considering potential periods of heightened susceptibility and mixture effects.Trial registration numberNCT00129324.

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Maternal serum PFOA concentration and DNA methylation in cord blood: A pilot study

Cited by 29 publications

References 22 publications

Prenatal exposure to perfluoroalkyl substances and adipocytokines: the HOME Study

Prenatal exposure to perfluoroalkyl substances and adipocytokines: the HOME Study

Application of the Key Characteristics of Carcinogens to Per and Polyfluoroalkyl Substances

Adolescent follow-up in the Health Outcomes and Measures of the Environment (HOME) Study: cohort profile

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