Maternal serum alfa‐fetoprotein levels in the pregnancy complicated by hypertension

Clayton-Hopkins, Judith A.; Olsen, P N; Blake, Anne P.

doi:10.1002/pd.1970020108

Cited by 13 publications

(4 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings are in keeping with reports of a study by Walters et al [7] However, it is in contrast with finding by Clayton-Hopkins et al [20] which reported significantly higher mean serum AFP levels in pre-eclamptics than in normotensive controls. However, no eclamptic was recruited into the study by Clayton-Hopkins et al [20] Pre-eclampsia was also diagnosed in the second half of pregnancy, by an increase in systolic blood pressure of 20mmHg and diastolic blood pressure of 10mmHg over a previous reading in two successive visits to the physician accompanied by either or both edema and proteinuria, in their study. The different study definition of hypertension in pregnancy used by Clayton Hopkins et al may explain why their findings are not congruent with results of this study.…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Alpha Fetoprotein as a Marker of Severe Disease and Foetal Outcome in Pregnancy Induced Hypertension

Olumodeji

Adewara²,

Adeyemo³

et al. 2019

ijirms

View full text Add to dashboard Cite

Background: Pregnancy-induced hypertension represents the most common medical complication of pregnancy and contributes significantly to maternal and neonatal morbidity and mortality. Many theories have been implicated in its genesis, crucial among which is the defective 2nd wave of trophoblastic invasion/placentation. Maternal serum alpha fetoprotein is a marker of placental abnormalities and may correlate with clinical features of significant management implications. This study evaluated the role of maternal Alpha-fetoprotein concentration as a marker of disease severity and foetal outcome in patients with pregnancy induced hypertension at the Federal Teaching Hospital, Ido-Ekiti, Ekiti state, Nigeria. Methodology: This was a prospective study in which 44 patients with PIH and 88 matched controls that satisfied the inclusion criteria were recruited using convenience sampling technique for cases and systematic random sampling for controls. Relevant socio-demographic, maternal medical and obstetric characteristics, alpha-fetoprotein levels and fetal outcome measures were obtained. A p-value of less than 0.05 was considered statistically significant. SPSS 20.0 statistical package (SPSS Inc, Chicago, IL, USA) was used for statistical analysis. Results: The prevalence of PIH in the study was 15.3%. The difference in the mean (±2SD) serum level of alpha fetoprotein (AFP) between the cases (207±156.2ng/ml) and control group (165.2±115.1ng/ml) was not statistically significant (p=0.079). The mean (±2SD) birth weight of babies born to women with PIH in this study was 2.7±0.6kg which was significantly lower (p<0.001; 95%CI 3.0 – 3.1)) than the mean birth weights of 3.2±0.4kg of babies of normotensive controls. The mean (± 2SD) Apgar scores at both 1 minute and 5 minutes were both significantly lower in the PIH group (6.7±1.8 and 8.4±1.5 respectively) than among the normotensive women (7.6±1.2 and 8.9±1.1 respectively). Thirty-one point eight percentage of babies born to women in the PIH group and 11.4% of babies of normotensive controls required admission into special care baby unit (SCBU) (Odds Ratio=1.17; 95%CI (0.24-5.76) Serum AFP had a reasonable negative correlation with both birth weight (r=-0.47, p=0.001) and Apgar score at 5 minute (r=-0.44, p=0.002). At 2 MoM serum AFP level, sensitivity and specificity for severe PIH were 36% and 90% respectively. Conclusion: Maternal serum AFP levels showed reasonable positive correlation with disease severity and adverse fetal outcome that warrants further investigation. Maternal serum AFP can be useful in identifying pregnant women with PIH at risk of having severe disease and adverse foetal outcome.

show abstract

Section: Discussionsupporting

confidence: 90%

“…This further strengthens the possible role of AFP as potential markers of severity in PIH as suggested by other studies. [5,20] Multiple linear regression analysis showed that serum AFP increased as birth weights reduced (Table 12). Serum AFP had significant association with BMI and Apgar scores when adjusted for other variables.…”

Section: Discussionmentioning

confidence: 99%

Alpha Fetoprotein as a Marker of Severe Disease and Foetal Outcome in Pregnancy Induced Hypertension

Olumodeji

Adewara²,

Adeyemo³

et al. 2019

ijirms

View full text Add to dashboard Cite

show abstract

“…All the bags tested, apart from the Air-Viva, produced satisfactory results at both tidal volumes with zero carbon dioxide during the inspiratory phase (figure). With the Air-Viva, however, the inspired carbon dioxide concentration rose immediately-that is, rebreathing occurred-and after [20][21][22][23][24][25][26][27][28][29][30] seconds reached a plateau of 2%, which was then maintained throughout the five and 15 minute periods. Increasing the tidal volume did not influence this rise in inspired carbon dioxide.…”

Section: Methods and Resultsmentioning

confidence: 99%

Case-Control Study of Severe Pre-eclampsia of Early Onset

Moore

Redman

1984

Obstetrical & Gynecological Survey

View full text Add to dashboard Cite

Twenty four women with severe pre-eclampsia diagnosed before 34 weeks' gestation were compared with 48 randomly selected controls matched for age and parity. Subjects were studied in the puerperium using a questionnaire, clinical examination, and review of case records. A history of infertility, headaches (particularly migraine), pre-eclampsia in a previous pregnancy, or a raised serum a-fetoprotein concentration at the time of screenri ing for neural tube defect in the index pregnancy were all identified as significant risk factors in the pre-eclamptic women. Maternal age, a history of chronic hypertension or renal disease, or excessive maternal weight were not significantly associated with pre-eclampsia. Almost all the infants of pre-eclamptic women showed retarded growth: 18 were below the 10th centile and only one weighed more than the 25th centile. Four babies died.These observations indicate that pre-eclampsia of early onset may differ from the late onset disease not only in its very high perinatal morbidity and mortality but in its distinctive maternal risk factors.

show abstract

“…It is of interest in this discussion that excessive placental secretions of neurokinin have recently been associated with pre-eclampsia in the third trimester of pregnancy (333). It has long been known that pre-eclampsia is associated with elevated AFP levels (334,335).…”

Section: Afp Fragmentsmentioning

confidence: 99%

Alpha-fetoprotein Structure and Function: Relevance to Isoforms, Epitopes, and Conformational Variants

Mizejewski

2001

Exp Biol Med (Maywood)

246

205

View full text Add to dashboard Cite

Mammalian alpha-fetoproteln (AFP) Is classified as a member of the albuminoid gene superfamily consisting of albumin, AFP, vitamin D (Gc) protein, and alpha-albumin. Molecular variants of AFP have long been reported In the biomedical literature. Early studies Identified Isoelectrlc pH isoforms and lectin-binding variants of AFP, which differed In their physicochemical properties, but not In amino acid composition. Genetic variants of AFP, differing in mRNA kllobase length, were later extensively described in rodent models during fetal/perinatal stages, carcinogenesis, and organ regeneration. With the advent of monoclonal antibodies in the early 1980s, multiple antigenic epitopes on native AFP were detected and categorized, culminating In the Identification of six to seven major epltopes. During this period, various AFP-blndlng proteins and receptors were reported to inhibit certain AFP Immunoreactlons. Concomlttantly, human and rodent AFP were cloned and the amino acid sequences of the translated proteins were divulged. Once the amino acid composition of the AFP molecule was known, enzymatic fragments could be identified and synthetic peptide segments synthesized. Following discovery of the molten globule form In 1981,the existence of transitory, intermediate forms of AFP were acknowledged and their physiological significance was realized. In the present review, the various Isoforms and variants of AFP are discussed In light of their potential biological relevance.

show abstract

Maternal serum alfa‐fetoprotein levels in the pregnancy complicated by hypertension

Cited by 13 publications

References 22 publications

Alpha Fetoprotein as a Marker of Severe Disease and Foetal Outcome in Pregnancy Induced Hypertension

Alpha Fetoprotein as a Marker of Severe Disease and Foetal Outcome in Pregnancy Induced Hypertension

Case-Control Study of Severe Pre-eclampsia of Early Onset

Alpha-fetoprotein Structure and Function: Relevance to Isoforms, Epitopes, and Conformational Variants

Contact Info

Product

Resources

About