Maternal selenium deficiency in mice promotes sex‐specific changes to urine flow and renal expression of mitochondrial proteins in adult offspring

Neal, Elliott S.; Hofstee, Pierre; Askew, Montana R.; Kent, Nykola L.; Bartho, Lucy A.; Perkins, Anthony V.; Cuffe, James

doi:10.14814/phy2.14785

Cited by 5 publications

(4 citation statements)

References 34 publications

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“…38 Moreover, maternal Se deficiencies alter the fetal development and predispose the adult offspring to thyroid dysfunction and fetal growth restriction via the alterations of mitochondrial protein expression. 39 Due to the key effect of mitochondrial dysfunctions induced by Se deficiencies on disease progression, the supplementation of antioxidant compounds including sodium selenite (Na 2 SeO 3 ), sodium selenate (Na 2 SeO 4 ) and Se enriched yeast (SY) has been applied to ameliorate the oxidative stress damage caused by the exposure of bisphenol A (BPA), 40 doxorubicin, 41 monosodium glutamate, 42 aluminum, 43 docetaxel (DTX), 44 sodium azide (SA) 45 and aflatoxin B1 (AFB1) 46 via the promotion of mitochondrial functions. Furthermore, the artificial selenylation modifications of polymannuronate, polysaccharides and galactomannan (GM) have been confirmed to promote neuroprotection, 47,48 antiinflammatory, 49,50 anti-tumor activity, 51,52 hepatic protection 53,54 and antiglycative activity 55 of these biopolymers via the promotion of antioxidant defense system.…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effect of Selenium Doped Carbon Quantum Dots Supplementation on the in vitro Development Competence of Ovine Oocytes

Wang¹,

Ren²,

Liu³

et al. 2022

IJN

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Background: After the synthesis of selenium doped carbon quantum dots (Se/CDs) via a step-by-step hydrothermal synthesis method with diphenyl diselenide (DPDSe) as precursor, the beneficial effects of Se/CDs' supplementation on the in vitro development competence of ovine oocytes were firstly investigated in this study by the assay of maturation rate, cortical granules' (CGs) dynamics, mitochondrial activity, reactive oxygen species (ROS) production, epigenetic modification, transcript profile, and embryonic development competence. Results:The results showed that the Se/CDs' supplementation during the in vitro maturation (IVM) process not only enhanced the maturation rate, CGs' dynamics, mitochondrial activity and embryonic developmental competence of ovine oocytes, but remarkably decreased the ROS production level of ovine oocytes. In addition, the expression levels of H3K9me3 and H3K27me3 in the ovine oocytes were significantly up-regulated after the Se/CDs' supplementation, in consistent with the expression levels of 5mC and 5hmC. Moreover, 2994 up-regulated differentially expressed genes (DEGs) and 846 repressed DEGs were found in the oocytes after the Se/ CDs' supplementation. According to the analyses of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG), these DEGs induced by the Se/CDs' supplementation were positively related to the progesterone mediated oocyte maturation and mitochondrial functions. And these remarkably up-regulated expression levels of DEGs related to oocyte maturation, mitochondrial function, and epigenetic modification induced by the Se/CDs' supplementation further confirmed the beneficial effect of Se/CDs' supplementation on the in vitro development competence of ovine oocytes. Conclusion:The Se/CDs prepared in our study significantly promoted the in vitro development competence of ovine oocytes, benefiting the extended research about the potential applications of Se/CDs in mammalian breeding technologies.

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Section: Discussionmentioning

confidence: 99%

Beneficial Effect of Selenium Doped Carbon Quantum Dots Supplementation on the in vitro Development Competence of Ovine Oocytes

Wang¹,

Ren²,

Liu³

et al. 2022

IJN

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“…We have previously reported that both glucose intolerance and other disease parameters such as renal dysfunction may be occurring in this model due to impaired thyroid function [ 14 , 30 ]. Similarly, the reduced exercise performance in the current model may relate to impaired thyroid function.…”

Section: Discussionmentioning

confidence: 99%

Selenium Deficiency during Pregnancy in Mice Impairs Exercise Performance and Metabolic Function in Adult Offspring

2022

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Selenium deficiency during the perinatal period programs metabolic dysfunction in offspring. Postnatal exercise may prevent the development of programmed metabolic disease. This study investigated the impact of selenium deficiency on offspring exercise behavior and whether this improved metabolic health. Female C57BL/6 mice were randomly allocated to control (NormalSe, >190 μg/Se/kg, n = 8) or low-selenium (LowSe, <50 μg/Se/kg, n = 8) diets from four weeks before mating. Male offspring were weaned at postnatal day (PN) twenty-four and placed on a normal chow diet. At PN60, mice were placed in cages with bi-directional running wheels and monitored until PN180. LowSe offspring had a reduced average weekly running speed and distance (p < 0.05). LowSe offspring exhibited glucose intolerance, with increased peak blood glucose (p < 0.05) and area under the curve following an intra-peritoneal injection of glucose (p < 0.05). Furthermore, mRNA expression of several selenoproteins within cardiac and skeletal muscle were increased in LowSe offspring (p < 0.05). The results indicated that selenium deficiency during development reduces exercise behavior. Furthermore, exercise does not prevent programmed glucose intolerance in low-selenium offspring. This highlights that exercise may not be the optimal intervention for metabolic disease in offspring impacted by selenium deficiency in early life.

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“…For instance, Hofstee et al found that maternal Se deficiency in rodents induces growth restriction, with significant decreases in fetal heart and kidney size, which predispose offspring to cardiovascular and renal dysfunction in later life [ 111 ]. These authors concluded that cardiovascular alterations took place when IUGR appear and that they are probably related to the impaired thyroid dysfunction that Se deficiency offspring present by decreasing the activity of the selenoproteins DIOs [ 120 , 121 ]. Laureano-Melo et al observed that maternal Se supplementation to Wistar rats was able to program carbohydrate and lipid metabolism, endocrine homeostasis, and feeding behavior, even in the adult offspring [ 122 ].…”

Section: Metabolic Programming and Sementioning

confidence: 99%

The Role of Selenoprotein Tissue Homeostasis in MetS Programming: Energy Balance and Cardiometabolic Implications

2022

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Selenium (Se) is an essential trace element mainly known for its antioxidant, anti-inflammatory, and anti-apoptotic properties, as it is part of the catalytic center of 25 different selenoproteins. Some of them are related to insulin resistance (IR) and metabolic syndrome (MetS) generation, modulating reactive oxygen species (ROS), and the energetic sensor AMP-activated protein kinase (AMPK); they can also regulate the nuclear transcription factor kappa-B (NF-kB), leading to changes in inflammation production. Selenoproteins are also necessary for the correct synthesis of insulin and thyroid hormones. They are also involved in endocrine central regulation of appetite and energy homeostasis, affecting growth and development. MetS, a complex metabolic disorder, can appear during gestation and lactation in mothers, leading to energetic and metabolic changes in their offspring that, according to the metabolic programming theory, will produce cardiovascular and metabolic diseases later in life. However, there is a gap concerning Se tissue levels and selenoproteins’ implications in MetS generation, which is even greater during MetS programming. This narrative review also provides an overview of the existing evidence, based on experimental research from our laboratory, which strengthens the fact that maternal MetS leads to changes in Se tissue deposits and antioxidant selenoproteins’ expression in their offspring. These changes contribute to alterations in tissues’ oxidative damage, inflammation, energy balance, and tissue function, mainly in the heart. Se imbalance also could modulate appetite and endocrine energy balance, affecting pups’ growth and development. MetS pups present a profile similar to that of diabetes type 1, which also appeared when dams were exposed to low-Se dietary supply. Maternal Se supplementation should be taken into account if, during gestation and/or lactation periods, there are suspicions of endocrine energy imbalance in the offspring, such as MetS. It could be an interesting therapy to induce heart reprogramming. However, more studies are necessary.

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Maternal selenium deficiency in mice promotes sex‐specific changes to urine flow and renal expression of mitochondrial proteins in adult offspring

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 5 publications

References 34 publications

Beneficial Effect of Selenium Doped Carbon Quantum Dots Supplementation on the in vitro Development Competence of Ovine Oocytes

Beneficial Effect of Selenium Doped Carbon Quantum Dots Supplementation on the in vitro Development Competence of Ovine Oocytes

Selenium Deficiency during Pregnancy in Mice Impairs Exercise Performance and Metabolic Function in Adult Offspring

The Role of Selenoprotein Tissue Homeostasis in MetS Programming: Energy Balance and Cardiometabolic Implications

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