2010
DOI: 10.1038/nature09457
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Abstract: Two forms of XCI ensure the selective silencing of female sex chromosomes during mouse embryogenesis. Imprinted XCI begins with the detection of Xist RNA expression on the paternal X chromosome (Xp) around the four cell stage of embryonic development. In the embryonic tissues of the inner cell mass (ICM), a random form of XCI occurs in blastocysts which inactivates either the Xp or the maternal X chromosome (Xm) 1,2. Both forms of XCI require the non-coding Xist RNA which coats the inactive X chromosome (Xi) f… Show more

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Cited by 158 publications
(265 citation statements)
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References 34 publications
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“…S7 C and E), suggesting a crucial role of Rnf12 transcription in the expression of Xist during preimplantation stage. In addition, RNF12 can specifically activate Xist expression in the paternal X chromosome during iXCI and also prevent excessive up-regulation of Xist with a rapid feedback mechanism (24,33). Together, these data show that Rnf12 overexpression can be used to compensate impaired iXCI by fine-tuning Xist expression in IVF female embryos.…”
Section: Resultsmentioning
confidence: 70%
See 1 more Smart Citation
“…S7 C and E), suggesting a crucial role of Rnf12 transcription in the expression of Xist during preimplantation stage. In addition, RNF12 can specifically activate Xist expression in the paternal X chromosome during iXCI and also prevent excessive up-regulation of Xist with a rapid feedback mechanism (24,33). Together, these data show that Rnf12 overexpression can be used to compensate impaired iXCI by fine-tuning Xist expression in IVF female embryos.…”
Section: Resultsmentioning
confidence: 70%
“…X chromosome inactivation (XCI) is a female-specific epigenetic event that occurs during early development for balancing the X-linked gene dosage between males and females. Previous studies show that disturbed XCI caused by mutation or deletion of related genes results in sex skewing in mice (22)(23)(24). Thus, we hypothesized that the IVF process may disturb the XCI status, thereby leading to the skewed sex ratio.…”
mentioning
confidence: 99%
“…Although we have discussed the potential impact of ZGA on the differences of X-inactivation in the extraembryonic lineages between rodents and other mammals, it may be also interesting to note the potential role of RNF12 (RLIM) in the oocyte. A maternal store of RNF12 was shown to be important for the upregulation of paternal Xist during preimplantation development in mice (Shin et al 2010). Although it is not known whether RNF12 exists in the oocyte of other mammals that do not have imprinted X-inactivation, if it does not, this could be an alternative speculation to the timing of ZGA.…”
Section: Humansmentioning
confidence: 99%
“…Elle est également indépendante de la méthylation de novo qui survient durant la croissance ovocytaire [14]. Une autre hypothèse implique la protéine RNF12 (ring finger protein 12) : en effet, son absence dans des embryons femelles empêche toute mise en place de l'inactivation de l'X soumise à empreinte en raison d'un défaut d'expression de l'allèle paternel de Xist [15]. RNF12 serait un élément déterminant pour l'expression de Xist en trans, même si le rôle exact de cette protéine n'est pas bien compris.…”
Section: Inactivation Du Chromosome X Soumise à Empreinteunclassified
“…Inconnue : empêche l'inactivation du Xm [9,12] RNF12 : active l'expression de Xist à partir de Xp [15] Empreinte paternelle ? Préinactivation du Xp [17,25] 4 .…”
Section: Empreinte(s) Maternelle(s) ?unclassified