Maternal risk factors of COVID-19-affected pregnancies: A comparative analysis of symptomatic and asymptomatic COVID-19 from the Q-PRECIOUS registry

Minisha, Fathima; Farrell, Thomas S. C.; Abuyaqoub, Salwa; Rahim, Abubaker Abdel; Ahmed, Huda; Omer, M; Abraham, Merlin; Teunissen, Franciscus; Gassim, Mahmoud; group, Q-PRECIOUS

doi:10.5339/qmj.2022.52

Cited by 5 publications

(6 citation statements)

References 19 publications

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“…Regarding neonatal outcomes, regarding neonatal length, birthweight, head circumference and Apgar score, we observed no significant differences between cases and controls. These findings are consistent with the literature, particularly in reference to the alpha variant of SARS-CoV-2 [ 42 , 43 , 44 ]. There are differences in the response of the immune system (in the mother and fetus) and symptoms among SARS-CoV-2 variants [ 45 , 46 ].…”

Section: Discussionsupporting

confidence: 93%

Low Interferon-γ Levels in Cord and Peripheral Blood of Pregnant Women Infected with SARS-CoV-2

et al. 2023

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COVID-19 is characterized by the immune system’s overreaction resulting in a ‘cytokine storm’, consisting in a massive release of cytokine into the bloodstream, leading to local and systemic inflammatory response. This clinical picture is further complicated in case of infection of patients with a peculiar immunological status, such as pregnancy. In this paper, we focused on Interferon-γ, which plays a pivotal immunomodulatory role in normal pregnancy and fetal development, as well as in defense against pathogens. In this study, we compared the levels of Interferon-γ and the Interferon autoantibodies of the peripheral and cord blood of pregnant women with confirmed mild COVID-19 and healthy pregnant women. The Interferon-γ was significantly lower both in the peripheral and cord blood of SARS-CoV-2-positive mothers, suggesting that infection can affect the fetal microenvironment even without severe maternal symptoms. In conclusion, further studies are needed to clarify whether lower levels of Interferon-γ due to SARS-CoV-2 infection affect the development or infection susceptibility of infants born to SARS-CoV-2-infected mothers.

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Section: Discussionsupporting

confidence: 93%

Low Interferon-γ Levels in Cord and Peripheral Blood of Pregnant Women Infected with SARS-CoV-2

et al. 2023

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“…On the contrary, out of 12 articles in this study, two stated the higher portion of COVID-19 cases in pregnancy was in the AMA group (Babic et al, 2022;Minisha et al, 2022). This might be explained by social factors, such as the likelihood that older women will encounter sick older relatives and children who are left in their care at home (Minisha et al, 2022). Despite the fact that COVID-19 had a lower percentage of AMA cases, the mortality and morbidity risks were higher compared with the younger aged pregnant women.…”

Section: Discussioncontrasting

confidence: 57%

“…Another study in Cameroon reported 64% of pregnant women with COVID-19 were 25-35 years old (Dingom et al, 2020). On the contrary, out of 12 articles in this study, two stated the higher portion of COVID-19 cases in pregnancy was in the AMA group (Babic et al, 2022;Minisha et al, 2022). This might be explained by social factors, such as the likelihood that older women will encounter sick older relatives and children who are left in their care at home (Minisha et al, 2022).…”

Section: Discussioncontrasting

confidence: 56%

A Literature Review of Advanced Maternal Age in Pregnant Women with COVID-19

Hapsari¹,

Hermadiputri²,

Sa’adi³

2022

IJRP

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Background: During pregnancy, the risk of severe manifestation of COVID-19 with a worse maternal outcome can become higher because of the alteration in the immune system and physiological function. In COVID-19 infection, several studies also stated the increased risk of severe disease in advanced maternal age (AMA). Considering that the death and severe case rates in advanced-aged pregnant women with COVID-19 were high, special attention should be focused on this matter. There was still little study that focused on the outcome of COVID-19 in pregnant women with advanced age as well. Therefore, this study aims to evaluate the risks and the outcomes of advanced maternal age-pregnancy with COVID-19. Method: The method used in this paper is the Literature Review which aspires to analyze the risk and the outcome of COVID-19 in advanced maternal-age pregnancy. The databases used in the source search are PubMed, Google Scholar, JAMA, and AJOG. The keywords for the search were advanced maternal age, COVID-19, and pregnancy. Results: The mortality and morbidity of AMA who had COVID-19 were higher than non-AMA pregnant women. Severe conditions of COVID-19 were increased in AMA patients. They were at risk of having ICU admission and intubation. Advanced-aged mothers were more likely to have comorbidity including obesity. They also had a higher risk of adverse pregnancy outcomes. Conclusion:The adverse maternal aged-pregnant women with COVID-19 had higher risks of having comorbidities, severe conditions of COVID-19, adverse pregnancy outcomes, and mortality. Therefore, early risk identification needs to be done to identify the special management for the patients.

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“…The evaluation of the registries, in turn, is the basis for developing guidelines, which must be dynamically adapted to new findings over the course of time. Some important registries are listed in ▶Table 3 [92][93][94][95][96][97][98][99][100][101][102][103].…”

Section: Registries On Pregnancies With Sars-cov-2 Infectionmentioning

confidence: 99%

COVID-19, Pregnancy, and Diabetes Mellitus

Kleinwechter,

Weber,

Liedtke

et al. 2023

Z Geburtshilfe Neonatol

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During the severe acute respiratory distress virus coronavirus type 2 (SARS-CoV-2) pandemic, many women were infected during their pregnancies. The SARS-CoV-2-induced coronavirus disease 19 (COVID-19) has an impact on maternal health and pregnancy outcomes; peripartum and perinatal morbidity and mortality are increased. Pregnancy is considered a risk factor for severe COVID-19 course. Additional risk factors during pregnancy are diabetes mellitus, gestational diabetes mellitus (GDM), and obesity. Systemic inflammation can lead to severe metabolic dysregulation with ketoacidosis. The endocrine pancreas is a target organ for SARS-CoV-2 and the fetal risk depends on inflammation of the placenta. Up to now there is no evidence that SARS-CoV-2 infection during pregnancy leads to permanent diabetes in mothers or their offspring via triggering autoimmunity or beta cell destruction. The frequently observed increased prevalence of GDM compared to the years before the pandemic is most likely due to changed lifestyle during lockdown. Furthermore, severe COVID-19 may be associated with the development of GDM due to worsening of glucose tolerance. Vaccination with a mRNA vaccine is safe and highly effective to prevent infection and to reduce hospitalization. Registries support offering evidence-based recommendations on vaccination for pregnant women. Even with the current omicron virus variant, there are increased risks for symptomatic and unvaccinated pregnant women.

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Maternal risk factors of COVID-19-affected pregnancies: A comparative analysis of symptomatic and asymptomatic COVID-19 from the Q-PRECIOUS registry

Cited by 5 publications

References 19 publications

Low Interferon-γ Levels in Cord and Peripheral Blood of Pregnant Women Infected with SARS-CoV-2

Low Interferon-γ Levels in Cord and Peripheral Blood of Pregnant Women Infected with SARS-CoV-2

A Literature Review of Advanced Maternal Age in Pregnant Women with COVID-19

COVID-19, Pregnancy, and Diabetes Mellitus

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