Maternal prenatal psychological distress and hair cortisol levels associate with infant fecal microbiota composition at 2.5 months of age

Aatsinki, Anna-Katariina; Keskitalo, Anniina; Laitinen, Ville; Munukka, Eveliina; Uusitupa, Henna-Maria; Lahti, Leo; Kortesluoma, Susanna; Mustonen, Paula; Rodrigues, Ana João; Coimbra, Bárbara; Huovinen, Pentti; Karlsson, Hasse; Karlsson, Lena

doi:10.1016/j.psyneuen.2020.104754

Cited by 50 publications

(54 citation statements)

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“…Thus, behind cytokine elevation and neurotransmitters depletion might be the involvement of the tryptophan pathway [ 16 , 22 , 23 ]. There is an interconnection between bacterial shifts [ 17 , 18 , 19 , 20 ] and how microglia respond to environmental stressors in a time- and sex-dependent manner [ 24 , 25 ]. CD4T initiates transcriptional maturation in microglia, and in its absence, it triggers a defective synaptic behavior [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

An Updated Narrative Mini-Review on the Microbiota Changes in Antenatal and Post-Partum Depression

Doroftei

Ilie

Diaconu³

et al. 2022

Diagnostics

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Background: Antenatal depression (AND) and post-partum depression (PPD) are long-term debilitating psychiatric disorders that significantly influence the composition of the gut flora of mothers and infants that starts from the intrauterine life. Not only does bacterial ratio shift impact the immune system, but it also increases the risk of potentially life-threatening disorders. Material and Methods: Therefore, we conducted a narrative mini-review aiming to gather all evidence published between 2018–2022 regarding microflora changes in all three stages of pregnancy. Results: We initially identified 47 potentially eligible studies, from which only 7 strictly report translocations; 3 were conducted on rodent models and 4 on human patients. The remaining studies were divided based on their topic, precisely focused on how probiotics, breastfeeding, diet, antidepressants, exogenous stressors, and plant-derived compounds modulate in a bidirectional way upon behavior and microbiota. Almost imperatively, dysbacteriosis cause cognitive impairments, reflected by abnormal temperament and personality traits that last up until 2 years old. Thankfully, a distinct technique that involves fecal matter transfer between individuals has been perfected over the years and was successfully translated into clinical practice. It proved to be a reliable approach in diminishing functional non- and gastrointestinal deficiencies, but a clear link between depressive women’s gastrointestinal/vaginal microbiota and clinical outcomes following reproductive procedures is yet to be established. Another gut-dysbiosis-driving factor is antibiotics, known for their potential to trigger inflammation. Fortunately, the studies conducted on mice that lack microbiota offer, without a shadow of a doubt, insight. Conclusions: It can be concluded that the microbiota is a powerful organ, and its optimum functionality is crucial, likely being the missing puzzle piece in the etiopathogenesis of psychiatric disorders.

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Section: Resultsmentioning

confidence: 99%

An Updated Narrative Mini-Review on the Microbiota Changes in Antenatal and Post-Partum Depression

Doroftei

Ilie

Diaconu³

et al. 2022

Diagnostics

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“…We tested sex, age, whether a female had an infant, and fecal glucocorticoid metabolite concentration (FGMC) as our predictor variables with bonobo gut microbiota composition and diversity as the response variable. We included these variables because they are associated with differences in FGMC and gut microbiota [77]- [81]. Statistics were run in R version 4.0.2 [82].…”

Section: Discussionmentioning

confidence: 99%

A Comparison Of Fecal Glucocorticoid Metabolite Concentration And Gut Microbiota Diversity In Bonobos (Pan paniscus)

Hickmott

Boose

Wakefield

et al. 2022

Preprint

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Host sex, age, diet, stress, and social environment have all been found to influence the gut microbiota. In non-human primates (NHP), recent evidence from gorillas found fecal glucocorticoid metabolite concentration (FGMC) had no significant role in structuring their gut microbiota, but there was a significant differential abundance between family Anaerolineaceae and gorilla FGMC. This pattern has yet to be examined in other NHP, like bonobos (Pan paniscus). We compared FGMC to 16S rRNA amplicons for 201 bonobo fecal samples collected in the wild across five months to evaluate the impact of stress, measured with FGMC, on the gut microbiota. Simpsons index was the only alpha diversity index to have a significant linear relationship with FGMC [R2 = 0.9643, F(4, 210) = 28.56, p = 0.0023]. FGMC level explained 1.63% of the variation in beta diversity for Jensen-Shannon Distance, 2.49% for Weighted UniFrac, and 3.53% for Unweighted UniFrac using PERMANOVAs. Differential abundance models showed seventeen taxa that were significantly correlated with FGMC. We found that genus SHD-231 in the family Anaerolinaceae was significant in our differential abundance model results, similar to western lowland gorilla abundance model results. These results suggest bonobos exhibit different patterns than gorillas in alpha and beta diversity measures and that members of the family Anaerolinaceae may be differentially affected by host stress across great apes. Incorporating FGMC into gut microbiota research can provide a more robust understanding of how stress impacts the gut microbiota of primates and humans and has important ties to overall host health.

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“…There is increasing evidence that microbial colonization begins in utero (Aagaard et al, 2014; Neu & Rushing, 2011) and perhaps in ovo (Dietz et al, 2019; Trevelline, MacLeod, et al, 2018) or through the eggshell microbiome (van Veelen et al, 2018), so the changes we demonstrate here in gravid lizards could also be a mechanism by which downstream products of the maternal stress response (in this case, CORT) influence offspring traits via maternal effects. Altered community structure in mothers can alter what microbes are transmitted between generations (Aatsinki et al, 2020; Jašarević et al, 2017; Mueller et al, 2015; Sonnenburg et al, 2016), as well as the metabolites available to developing embryos during development (Koren et al, 2012; Lv et al, 2018), both of which can have substantial influence on offspring phenotypes (Braniste et al, 2014; Gomez de Aguero et al, 2016), including immune (Winter & Bäumler, 2014) and hypothalamic development (Jašarević et al, 2018). Prenatal stress‐induced changes in offspring gut microbiota, probably mediated by changes initially to maternal microbiota, have been linked to behavioural disorders in laboratory studies: for example, acquisition of an altered microbiome from gestationally stressed mouse mothers alters bacterial metabolite profiles of exposed offspring, resulting in an increase in colonic hippuric acid, associated with neuropsychiatric disorders (Jašarević et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Context‐dependent effects of glucocorticoids on the lizard gut microbiome

et al. 2021

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The vertebrate gut microbiota (bacterial, archaeal and fungal communities of the gastrointestinal tract) has profound effects on key physiological processes of their hosts (Kohl, 2017;McFall-Ngai et al., 2013), including nutrient absorption, immune development and regulation of disease onset (Morgan et al., 2013). Changes to microbiome community structure can impact activity and function of microbial communities (Morgan et al., 2013), leading to neurological changes (Cryan & O'Mahony, 2011;Mackos et al., 2016), changes

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Maternal prenatal psychological distress and hair cortisol levels associate with infant fecal microbiota composition at 2.5 months of age

Cited by 50 publications

References 49 publications

An Updated Narrative Mini-Review on the Microbiota Changes in Antenatal and Post-Partum Depression

An Updated Narrative Mini-Review on the Microbiota Changes in Antenatal and Post-Partum Depression

A Comparison Of Fecal Glucocorticoid Metabolite Concentration And Gut Microbiota Diversity In Bonobos (Pan paniscus)

Context‐dependent effects of glucocorticoids on the lizard gut microbiome

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