Maternal plasma transforming growth factor-β1 (TGF-β1) and newborn size: the Araraquara Cohort Study

Dejani, Naiara Naiana; Nicoletti, Carolina Ferreira; Argentato, Perla Pizzi; Pereira, Ludmilla da Silva; Saraiva, Amanda Correia; Assis, Letícia Montanha de; Nakandakare, Patrícia Yury; Batista, Lívia Patricia Rodrigues; Teles, Laísla de França da Silva; Leitão, Maria Paula; Luzia, Liânia Alves; Medeiros, Alexandra Ivo de; Rondó, Patrícia H C

doi:10.1016/j.jped.2022.11.009

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…Nevertheless, several studies investigated maternal TGFβ1 levels and gestational outcomes with some significant findings. Negative associations were found between maternal TGFβ1 concentrations and birthweight as well as head circumference of offspring [ 40 ]. Moreover, decreased maternal serum TGFβ1 concentrations have also been observed in SGA gestations in the 34th gestational week, however this decrease disappeared at the 38th week [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Association between TGFβ1 Levels in Cord Blood and Weight Progress in the First Year of Life

et al. 2023

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Transforming growth factor beta-1 (TGFβ1) is an adipokine secreted from adipose tissue, placental tissue and immune cells with a role in cell proliferation, cell apoptosis and angiogenic proliferation. The role of TGFβ1 in pregnancy and child growth and the source of cord TGFβ1 are yet unknown. In this study, we sought to clarify the correlation of TGFβ1 levels with parameters of intrauterine growth and child growth during the first year of life, and to determine whether their source is primarily of fetal or maternal origin. Serum samples and anthropometric measurements were obtained from the LIFE Child cohort of 79 healthy mother–child pairs. Measurements were conducted using enzyme-linked immunosorbent assays. Statistical analyses including Mann–Whitney U-test, correlation analyses and linear regression analyses were performed using GraphPad Prism and R. TGFβ1 levels were significantly higher in cord than in maternal serum, suggesting a fetal origin. Multivariate regression analyses revealed strong positive associations between cord TGFβ1 levels at birth and child weight at U6. Furthermore, cord TGFβ1 was significantly correlated with child weight at approximately one year of age. An increase of 10,000 pg/mL in cord TGFβ1 concentrations at birth was associated with a higher body weight of 201 g at roughly one year of age when adjusted for sex.

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Section: Discussionmentioning

confidence: 99%

Association between TGFβ1 Levels in Cord Blood and Weight Progress in the First Year of Life

et al. 2023

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“…2.1. Participants Participants were 72 newborns randomly selected from the large prospective epidemiological 'Araraquara Cohort Study' study (Dejani et al 2023). Babies were drawn from those enrolled in the study from the Municipal Maternity Hospital in Araraquara city, São Paulo, Brazil.…”

Section: Experimental Protocol and Data Analysismentioning

confidence: 99%

“…Body composition according to a two-compartment model (fat-free mass (FFM) and fat mass (FM)) was measured by ADP using a Pea Pod ® (Cosmed, Concord, CA, USA) according to manufacturer's instructions as reported previously (Dejani et al 2023).…”

Section: Air Displacement Plethysmographymentioning

confidence: 99%

Determination of resistance at zero and infinite frequencies in bioimpedance spectroscopy for assessment of body composition in babies

Pinheiro-Castro,

Ramos-Silva,

de Carvalho Rondó

et al. 2024

Physiol. Meas.

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Objective.Bioimpedance spectroscopy (BIS) is a popular technique for the assessment of body composition in children and adults but has not found extensive use in babies and infants. This due primarily to technical difficulties of measurement in these groups. Although improvements in data modelling have, in part, mitigated this issue, the problem continues to yield unacceptably high rates of poor quality data. This study investigated an alternative data modelling procedure obviating issues associated with BIS measurements in babies and infants.ApproachBIS data are conventionally analysed according to the Cole model describing the impedance response of body tissues to an applied AC current. This approach is susceptible to errors due to capacitive leakage errors of measurement at high frequency. The alternative is to model BIS data based on the resistance-frequency spectrum rather than the reactance-resistance Cole model thereby avoiding capacitive error impacts upon reactance measurements.Main resultsThe resistance-frequency approach allowed analysis of 100% of data files obtained from BIS measurements in 72 babies compared to 87% successful analyses with the Cole model. Resistance-frequency modelling error (percentage standard error of the estimate) was half that of the Cole method. Estimated resistances at zero and infinite frequency were used to predict body composition. Resistance-based prediction of fat-free mass (FFM) exhibited a 30% improvement in the two-standard deviation limits of agreement with reference FFM measured by air displacement plethysmography when compared to Cole model-based predictions.SignificanceThis study has demonstrated improvement in the analysis of BIS data based on the resistance frequency response rather than conventional Cole modelling. This approach is recommended for use where BIS data are compromised by high frequency capacitive leakage errors such as those obtained in babies and infants.

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Inflammatory markers and their association with preeclampsia among pregnant women: A systematic review and meta-analysis

Puttaiah,

Kirthan,

Sadanandan

et al. 2024

Clinical Biochemistry

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Maternal plasma transforming growth factor-β1 (TGF-β1) and newborn size: the Araraquara Cohort Study

Cited by 3 publications

References 18 publications

Association between TGFβ1 Levels in Cord Blood and Weight Progress in the First Year of Life

Association between TGFβ1 Levels in Cord Blood and Weight Progress in the First Year of Life

Determination of resistance at zero and infinite frequencies in bioimpedance spectroscopy for assessment of body composition in babies

Inflammatory markers and their association with preeclampsia among pregnant women: A systematic review and meta-analysis

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