Maternal Outcomes and Clinical Characteristics of COVID-19 in Korean Pregnant Women during the Early Period of the Pandemic

Chung, Youseung; Choi, Dong-Hwan; Ilagan, John; Lee, Jun-Young; Yoon, Young Kyung

doi:10.3346/jkms.2021.36.e290

Cited by 5 publications

(5 citation statements)

References 35 publications

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“…30 The fatality rate of pregnant women with COVID-19 was 0.04%, which was not different from that of non-pregnant women of reproductive age (20–45 years), although the incidence rate of critical illness in pregnant women (3.3%) was nine times higher than that in non-pregnant women at reproductive age (0.4%). Even in three other studies conducted in the ROK, pregnant women with COVID-19 were not at higher risk of developing a severe disease, 26 27 31 which was similar to the results of previous studies conducted outside of the ROK. 13 14 18 19 20 21 22 23 24 25 28…”

Section: Discussionsupporting

confidence: 87%

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Maternal and Neonatal Outcomes in Pregnant Women With Coronavirus Disease 2019 in Korea

Chung

Kim

et al. 2022

J Korean Med Sci

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Background This study aimed to describe the maternal, obstetrical, and neonatal outcomes in pregnant women with coronavirus disease 2019 (COVID-19) and identify the predictors associated with the severity of COVID-19. Methods This multicenter observational study included consecutive pregnant women admitted because of COVID-19 confirmed using reverse transcriptase-polymerase chain reaction (RT-PCR) test at 15 hospitals in the Republic of Korea between January 2020 and December 2021. Results A total of 257 women with COVID-19 and 62 newborns were included in this study. Most of the patients developed this disease during the third trimester. Nine patients (7.4%) developed pregnancy-related complications. All pregnant women received inpatient treatment, of whom 9 (3.5%) required intensive care, but none of them died. The gestational age at COVID-19 diagnosis (odds ratio [OR], 1.096, 95% confidence interval [CI], 1.04–1.15) and parity (OR, 1.703, 95% CI, 1.13–2.57) were identified as significant risk factors of severe diseases. Among women who delivered, 78.5% underwent cesarean section. Preterm birth (38.5%), premature rupture of membranes (7.7%), and miscarriage (4.6%) occurred, but there was no stillbirth or neonatal death. The RT-PCR test of newborns’ amniotic fluid and umbilical cord blood samples was negative for severe acute respiratory syndrome coronavirus 2. Conclusion At the time of COVID-19 diagnosis, gestational age and parity of pregnant women were the risk factors of disease severity. Vertical transmission of COVID-19 was not observed, and maternal severity did not significantly affect the neonatal prognosis.

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Section: Discussionsupporting

confidence: 87%

“…17 Furthermore, the severity of COVID-19 in pregnant women is similar to that in non-pregnant women. 13 14 18 19 20 21 22 23 24 25 26 27 28…”

Section: Introductionmentioning

confidence: 99%

Maternal and Neonatal Outcomes in Pregnant Women With Coronavirus Disease 2019 in Korea

Chung

Kim

et al. 2022

J Korean Med Sci

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“…In the early period of the pandemic, specifically between January, 2020 and February, 2021, the prevalence of COVID-19 in pregnant women was lower (0.02%) than in nonpregnant women in reproductive age (0.14%) [17,18]. Furthermore, the disease severity in pregnant women was not significantly higher than in the general population [17,[19][20][21].…”

Section: Discussionmentioning

confidence: 91%

“…In South Korea alone, from January 20, 2020, there were over 25 million confirmed cases including reinfections, and COVID-19-related deaths have exceeded 28,000 as of October 10, 2022 [16]. In the early period of the pandemic, specifically between January, 2020 and February, 2021, the prevalence of COVID-19 in pregnant women was lower (0.02%) than in nonpregnant women in reproductive age (0.14%) [17,18]. Furthermore, the disease severity in pregnant women was not significantly higher than in the general population [17,[19][20][21].…”

Section: Discussionmentioning

confidence: 99%

Impact of Coronavirus Disease 2019 in Cesarean Delivery and Neonates: A Case-Control Study

Yang¹,

Park²,

Baek³

et al. 2023

Clin. Exp. Obstet. Gynecol.

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Background:The aim of this study was to compare the maternal, surgical, and neonatal outcomes in pregnant women with coronavirus disease 2019 (COVID-19) who underwent cesarean delivery at term and provide evidence for the management of parturient with COVID-19. Methods: This case-control study was conducted retrospectively and evaluated 67 cases of cesarean delivery between February 1 and May 31 performed at the Gyeongsang National University Changwon Hospital, Korea. Case group included women who had positive reverse transcriptase-polymerase chain reaction (RT-PCR) test within 7 days before delivery. Control group was selected based on mode of delivery and gestational age among women with negative RT-PCR result. Results: A total of 34 women with COVID-19 and 33 COVID-19-negative women and their neonate were included in this study. Preoperative C-reactive protein was higher in case group (6.4 mg/L vs 1.8 mg/L, p < 0.001), but preoperative and postoperative day 1 and 3 hemoglobin levels did not differ between groups. Postoperative complications were similar in both groups. Control group had higher 1-and 5-minute APGAR scores than case group (p = 0.006 and p = 0.005) and showed better results of cord blood analyses in cord blood pH and base deficit (p = 0.001 and p = 0.002). Neonatal admission to intensive care unit did not differ between groups and there was no vertical transmission of COVID-19. Conclusions: Pregnant women with coronavirus disease 2019 at term who underwent urgent cesarean delivery showed comparable surgical and neonatal outcomes except higher preroperative C-reactive protein levels compared to COVID-19-negative women.

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“…However, a study comparing pregnant women with confirmed COVID-19 to non-pregnant women in Korea from January 2020 to February 2021 found that the incidence of COVID-19 in pregnant women (0.02%) was lower than the incidence in non-pregnant women of the same age group (0.14%) and non-pregnant women of all age groups (0.15%) [ 11 ]. Furthermore, until April 2021, all pregnant women with COVID-19 in Korea were treated in general wards, while 0.87% of non-pregnant women of the same age were treated in the ICU [ 12 ]. Previous studies related to COVID-19 in pregnant women in Korea were limited to data retrieved before the period when the Delta variant predominated.…”

Section: Introductionmentioning

confidence: 99%

Analysis of pregnant women with critically severe COVID-19 in Republic of Korea from February 2020 and December 2021

Lee

Kim

et al. 2023

PHRP

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Objectives: This study aimed to describe the characteristics and risk factors for severe disease in pregnant women infected with coronavirus disease 2019 (COVID-19) from the early days of the COVID-19 epidemic in Korea to the predominant period of the Delta variant.Methods: A retrospective cohort study was conducted among pregnant women diagnosed with COVID-19 between February 2020 and December 2021. Logistic regression analysis was performed to compare severe and mild cases after adjusting for pregnant women’s age, nationality, infection route, outbreak area, infection period, symptoms, underlying disease, smoking status, trimester, and COVID-19 vaccination status.Results: In total, 2,233 pregnant women were diagnosed with COVID-19 by December 2021. Among these, 96.7% had mild symptoms, 3.3% had severe symptoms, and 0.04% died. The risk factors for severe disease in pregnant women with confirmed COVID-19 were being in the age group of 35 to 45 years, having hyperlipidemia, being in the second or third trimester of pregnancy at the time of COVID-19 diagnosis, being infected during the Delta-predominant period, and having a fever (≥38 °C) at diagnosis. Furthermore, 47.1% of patients in the mild group and 84.9% of patients in the severe group had 3 or more risk factors.Conclusion: Pregnant women with COVID-19 mainly experienced mild symptoms, but those with risk factors were at a higher risk of developing severe symptoms. Therefore, treatment and follow-up management should be thoroughly implemented.

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Maternal Outcomes and Clinical Characteristics of COVID-19 in Korean Pregnant Women during the Early Period of the Pandemic

Cited by 5 publications

References 35 publications

Maternal and Neonatal Outcomes in Pregnant Women With Coronavirus Disease 2019 in Korea

Maternal and Neonatal Outcomes in Pregnant Women With Coronavirus Disease 2019 in Korea

Impact of Coronavirus Disease 2019 in Cesarean Delivery and Neonates: A Case-Control Study

Analysis of pregnant women with critically severe COVID-19 in Republic of Korea from February 2020 and December 2021

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