Maternal Milk and Serum Vitamin B12, Folic Acid, and Protein Levels in Indian Subjects

Jathar, V. S.; Kamath, Sandeep; Parikh, Mahendra; Rege, D. V.; Satoskar, R. S.

doi:10.1136/adc.45.240.236

Cited by 37 publications

(17 citation statements)

References 29 publications

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“…A study published by Jathar et al . [36] showed no change in cobalamin concentration in the breast milk of lacto-vegetarian mothers compared to non-vegetarians, even though a decrease in the serum cobalamin of lacto-vegetarians mothers have been reported. In our study, we did not analyze the breast milk composition, but we observed an increase of approximately 120% in the plasma Hcy concentration of the offspring (PND 5) breastfed by dams fed the deficient diet.…”

Section: Discussionmentioning

confidence: 72%

Effect of Vitamin B Deprivation during Pregnancy and Lactation on Homocysteine Metabolism and Related Metabolites in Brain and Plasma of Mice Offspring

et al. 2014

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Epidemiological and experimental studies indicate that the altered fetal and neonatal environment influences physiological functions and may increase the risk of developing chronic diseases in adulthood. Because homocysteine (Hcy) metabolic imbalance is considered a risk factor for neurodegenerative diseases, we investigated whether maternal Vitamin B deficiency during early development alters the offspring's methionine-homocysteine metabolism in their brain. To this end, the dams were submitted to experimental diet one month before and during pregnancy or pregnancy/lactation. After birth, the offspring were organized into the following groups: control (CT), deficient diet during pregnancy and lactation (DPL) and deficient diet during pregnancy (DP). The mice were euthanized at various stages of development. Hcy, cysteine, glutathione (GSH), S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), folate and cobalamin concentrations were measured in the plasma and/or brain. At postnatal day (PND) 0, total brain of female and male offspring exhibited decreased SAM/SAH ratios. Moreover, at PND 28, we observed decreased GSH/GSSG ratios in both females and males in the DPL group. Exposure to a Vitamin B-deficient diet during the ontogenic plasticity period had a negative impact on plasma folate and brain cortex SAM concentrations in aged DPL males. We also observed decreased plasma GSH concentrations in both DP and DPL males (PND 210). Additionally, this manipulation seemed to affect the female and male offspring differently. The decreased plasma GSH concentration may reflect redox changes in tissues and the decreased brain cortex SAM may be involved in changes of gene expression, which could contribute to neurodegenerative diseases over the long term.

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Section: Discussionmentioning

confidence: 72%

Effect of Vitamin B Deprivation during Pregnancy and Lactation on Homocysteine Metabolism and Related Metabolites in Brain and Plasma of Mice Offspring

et al. 2014

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“…Changes in total serum BL, during pregnancy and in the puerperium have been thoroughly studied by many workers (Karlin and Dumont, 1955;Boger et al, 1956b;Boger, Wright, and Bayne, 1957;Izak, Rachmilewitz, Stein, Berkovici, Sadovsky, Arnovitch, and Grossovicz, 1957;Baker et al, 1958;Baker et al, 1962;Low-Beer, McCarthy, Austad, Brzechwa-Ajdukiewicz, and Read, 1968;Hibberd and Spencer, 1970;Jathar, Kamath, Parikh, Rege, and Satoskar, 1970). The normal picture is of a slowly declining blood level, steepening somewhat towards term but rising again rapidly and spontaneously after delivery.…”

Section: Discussionmentioning

confidence: 99%

Cobalamins in human pregnancy and lactation

Craft¹,

Matthews²,

Linnell³

1971

J Clin Pathol

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SYNOPSIS Samples of maternal and foetal blood and of human milk, cow's milk, and dried cow's milk have been analysed for cobalamins by chromatography and bioautography. Plasma cobalamins in late pregnancy and after delivery differed quantitatively from those in healthy non-pregnant women. Differences in the proportions of plasma cobalamins were also observed between mothers and their newborn infants. The findings suggest that methylcobalamin may be a more labile plasma form of the vitamin than 5-deoxyadenosyl cobalamin. Breast milk from healthy mothers contained more deoxyadenosylcobalamin and proportionately less methylcobalamin than their plasma. Cyanocobalamin given parenterally to lactating women was detected in the plasma, and high concentrations appeared unchanged in the milk. The B12 in fresh cow's milk was found to be largely 5-deoxyadenosyl cobalamin whereas dried milk contained only hydroxocobalamin and a little cyanocobalamin. The nutritional implications of the findings, and their bearing on problems of cobalamin transport, are discussed.

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“…Maternal intake of vitamin B-12 has been associated with breast milk cobalamin concentrations at 1, 6, and 12 mo postpartum in studies in Kenyan and Guatemalan lactating women (52,53). Several studies found lower concentrations of breast milk vitamin B-12 in macrobiotic or vegetarian mothers than in omnivorous mothers (54)(55)(56). Other maternal factors that influence vitamin B-12 in breast milk include conditions such as pernicious anemia or malabsorption that impair maternal vitamin B-12 status (43).…”

Section: Vitamin B-12mentioning

confidence: 99%

Overview of Nutrients in Human Milk

Dror

Allen

2018

Advances in Nutrition

230

220

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The WHO recommends exclusive breastfeeding for the first 6 mo of life to promote optimal infant health and development. Understanding the micro- and macronutrient concentrations of human milk and how each nutrient fluctuates with lactational stage, maternal factors, and supplementation is imperative for supporting good breastfeeding practices. Where maternal undernutrition compromises human milk quality, a thorough awareness of the effectiveness of interventions can direct efforts to achieve both maternal and infant nutrient sufficiency. This review of current knowledge covers trends in nutrient concentrations over the course of lactation and describes the influence of maternal intake, status, supplementation, and other factors on human milk concentrations of each nutrient.

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Maternal Milk and Serum Vitamin B12, Folic Acid, and Protein Levels in Indian Subjects

Cited by 37 publications

References 29 publications

Effect of Vitamin B Deprivation during Pregnancy and Lactation on Homocysteine Metabolism and Related Metabolites in Brain and Plasma of Mice Offspring

Effect of Vitamin B Deprivation during Pregnancy and Lactation on Homocysteine Metabolism and Related Metabolites in Brain and Plasma of Mice Offspring

Cobalamins in human pregnancy and lactation

Overview of Nutrients in Human Milk

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