Maternal Microbiota, Cortisol Concentration, and Post-Partum Weight Recovery Are Dependent on Mode of Delivery

Selma‐Royo, Marta; García-Mantrana, Izaskun; Calatayud, Marta; Parra-Llorca, Anna; Martínez‐Costa, Cecilia; Collado, María Carmen

doi:10.3390/nu12061779

Cited by 11 publications

(9 citation statements)

References 91 publications

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“…Interestingly, the microbiome appeared to show signi cant discrepancies in the vaginal uid samples of pregnant women who were subjected to different labour modes. This conclusion was consistent with Marta Selma-Royo et al [21] and Romero R et al [22], which described the variations occurred during gestation, mainly in the intestinal and vaginal microbiomes. These studies also indicated that delivery mode signi cantly affected the maternal microbiota composition at delivery.…”

Section: Discussionsupporting

confidence: 91%

Maternal Vaginal Fluids Play A Major Role In The Colonization of The Neonatal Intestinal Microbiota

Tang

Zhang

Xie

et al. 2021

Preprint

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Background: Caesarean delivery (CD) is associated with newborns’ health risks due to the blocking of microbiome transfer. To understand the vertical bacterial seeding and reduce CD disadvantages, microbiome transmissions via anal and genital routes were investigated, and the efficiency of vaginal fluid swabbing treatment was evaluated using 16s rDNA sequencing-based techniques.Results: Pregnant women were recruited in the Women and Children’s Hospital, School of Medicine, Xiamen University from June 1st to August 15th, 2017. Maternal faeces (n = 26), maternal vaginal fluids (n = 26), and neonatal transitional stools (n = 26) were collected, while the participants underwent natural delivery (ND) (n = 6), CD (n = 4) and CD with vaginal fluid swabbing (CS) on their newborns (n = 16). 26 mothers with the median age 26.50 (25.00-27.25) years showed no substantial clinical differences. The newborns’ gut microbiota altered among ND, CD and CS, and clustered into two groups (PERMANOVA P < 0.01) of swabbing and no-swabbing exposure. Gut colonization of ND babies majorly originated from maternal vaginal microbes (PERMANOVA P = 0.08), no vertical transmission was observed via anal route in any group. The vaginal transfer partially occurred by swabbing, in which the phyla Firmicutes and Proteobacteria and the genera Lactobacillus, Bacteroides, and Escherichia-Shigella in newborns were similar to their mothers. The recovered taxa predicted KEGG functions of biosynthesis, metabolism, and DNA replication and repair with benefits of low risks of digestive, cardiovascular, and immune diseases.Conclusions: The newborn’s gut microbiota is mainly shaped by maternal vaginal microbiota, and aberrant colonization initiated by CD is partly mitigated by the swabbing treatment.

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Section: Discussionsupporting

confidence: 91%

Maternal Vaginal Fluids Play A Major Role In The Colonization of The Neonatal Intestinal Microbiota

Tang

Zhang

Xie

et al. 2021

Preprint

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“…Children microbiota clustering was generated at the genus level as described previously [ 19 ] using the phyloseq [ 20 ], cluster [ 21 ], MASS [ 22 ], clusterSim [ 23 ], and ade4 R packages [ 24 ]. Briefly, the Jensen–Shannon distance and partitioning around medoid (PAM) clustering were used.…”

Section: Methodsmentioning

confidence: 99%

The Composition and Diversity of the Gut Microbiota in Children Is Modifiable by the Household Dogs: Impact of a Canine-Specific Probiotic

et al. 2021

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The development of the infant gut microbiota is initiated during pregnancy and continued through early life and childhood, guided by the immediate environment of the child. Our aim was to characterize the shared microbiota between dogs and children as well as to determine whether introduction to dogs of a dog-specific probiotic combination modifies the transfer process. We studied 31 children from allergic families with pet dog(s) and 18 control families without a dog. Altogether 37 dogs were randomized for a 4-week period in a double-blind design to receive canine-derived probiotic product containing a mixture of L. fermentum, L. plantarum, and L. rhamnosus, or placebo. Fecal samples from children and dogs were taken before and after the treatment. Distinctive gut microbiota composition was observed in children with dogs compared to those without a dog, characterized by higher abundance of Bacteroides and short-chain fatty acid producing bacteria such as Ruminococcus and Lachnospiraceae. Probiotic intervention in dogs had an impact on the composition of the gut microbiota in both dogs and children, characterized by a reduction in Bacteroides. We provide evidence for a direct effect of home environment and household pets on children microbiota and document that modification of dog microbiota by specific probiotics is reflected in children’s microbiota.

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“… Nunn et al (2021) considered that the decrease in relative abundance of Lactobacillus in postpartum women might be associated with the maternal estrogen levels falling precipitously after placenta removal. Selma-Royo et al (2020) found that the mode of delivery influenced vaginal microbiota composition manifesting the changes of relative abundance of various genera. Therefore, it is worthwhile further exploring factors contributing to the changes of vaginal microbiota, especially in postpartum women.…”

Section: Discussionmentioning

confidence: 99%

The relationship between pelvic floor functions and vaginal microbiota in 6–8 weeks postpartum women

Zhang

Lin

et al. 2022

Front. Microbiol.

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The impairment of pelvic floor muscle functions and Lactobacillus-deficient vaginal microbiota is common in postpartum women. However, few studies have explored the correlation between pelvic floor muscle functions and vaginal microbiota. Given this research gap, our study aims to investigate any potential association between these two conditions of postpartum women (6–8 weeks after childbirth). A total of 230 women who required postpartum pelvic floor function examination at Peking University International Hospital from December 2021 to April 2022 were enrolled in this study. The collected questionnaire information included progestational weight, body mass index (BMI), weight gain during pregnancy, neonatal weight, delivery type, multiparity, postpartum time, and urinary incontinence (UI). A total of 187 samples of vaginal secretions were collected, and the vaginal microbiota was detected by 16S rRNA sequence analysis. Finally, 183 samples were analyzed in the trial. All individuals were divided into two groups according to the results of pelvic floor muscle assessment to explore the difference between the incidence of postpartum urinary incontinence and vaginal microbiota. We found that the prevalence of UI was higher in the group with weakened pelvic floor muscles. Vaginal delivery, overweight, age, neonatal weight, and weight gain during pregnancy were all risk factors for postpartum urinary incontinence. The vaginal microbiome was no longer Lactobacillus dominant of most postpartum women (91.8%), while the diversity of microbiota increased. The Lactobacillus-deficient community, commonly labeled as community state type (CST) IV, was sub-divided into four communities. The abundance of vaginal Lactobacillus decreased in the group with compromised pelvic muscle functions, while the species richness and diversity increased significantly. In conclusion, the decreased pelvic floor muscle functions of postpartum women 6–8 weeks after delivery may disrupt the balance of vaginal microbiota, and the restoration of pelvic floor functions may contribute to a healthy and balanced vaginal microbiota.

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Maternal Microbiota, Cortisol Concentration, and Post-Partum Weight Recovery Are Dependent on Mode of Delivery

Cited by 11 publications

References 91 publications

Maternal Vaginal Fluids Play A Major Role In The Colonization of The Neonatal Intestinal Microbiota

Maternal Vaginal Fluids Play A Major Role In The Colonization of The Neonatal Intestinal Microbiota

The Composition and Diversity of the Gut Microbiota in Children Is Modifiable by the Household Dogs: Impact of a Canine-Specific Probiotic

The relationship between pelvic floor functions and vaginal microbiota in 6–8 weeks postpartum women

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