Maternal medical and behavioral risk factors for congenital diaphragmatic hernia

McAteer, Jarod P.; Hecht, Avram S.; Roos, Anneclaire J. De; Goldin, Adam B.

doi:10.1016/j.jpedsurg.2013.09.025

Cited by 20 publications

(17 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, we observed significant association for maternal periconceptional alcohol intake. Accordingly, previous studies by Felix et al in 2008 and McAteer et al in 2014 described association between the occurrence of CDH and maternal periconceptional alcohol intake [ 11 , 16 ]. In general, CDH is not part of the foetal alcohol related anomaly spectrum [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…The most common co-occuring malformations compromise the cardiovascular, genitourinary, gastrointestinal or the central nervous system [ 7 ]. Besides genetic factors the following environmental risk factors have been previously associated with the development of CDH: maternal body mass index (BMI) [ 8 ], maternal age [ 9 , 10 ], pre-gestational diabetes [ 11 ], maternal pre-gestational hypertension [ 12 ], pre-conceptional diet, especially riboflavin supplementation [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Parental risk factors for congenital diaphragmatic hernia – a large German case-control study

et al. 2021

View full text Add to dashboard Cite

Background Evidence for periconceptional or prenatal environmental risk factors for the development of congenital diaphragmatic hernia (CDH) is still scarce. Here, in a case-control study we investigated potential environmental risk factors in 199 CDH patients compared to 597 healthy control newborns. Methods The following data was collected: time of conception and birth, maternal BMI, parental risk factors such as smoking, alcohol or drug intake, use of hairspray, contact to animals and parental chronic diseases. CDH patients were born between 2001 and 2019, all healthy control newborns were born in 2011. Patients and control newborns were matched in the ratio of three to one. Results Presence of CDH was significantly associated with maternal periconceptional alcohol intake (odds ratio = 1.639, 95% confidence interval 1.101–2.440, p = 0.015) and maternal periconceptional use of hairspray (odds ratio = 2.072, 95% confidence interval 1.330–3.229, p = 0.001). Conclusion Our study suggests an association between CDH and periconceptional maternal alcohol intake and periconceptional maternal use of hairspray. Besides the identification of novel and confirmation of previously described parental risk factors, our study underlines the multifactorial background of isolated CDH.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Parental risk factors for congenital diaphragmatic hernia – a large German case-control study

et al. 2021

View full text Add to dashboard Cite

show abstract

“…We initially adjusted for maternal age at delivery. Then we selected potential a priori confounders, including smoking habits, alcohol consumption, prepregnancy BMI and DM/ GDM, based on past evidence (25)(26)(27) and adjusted for these in addition to other factors associated with CDH in the present study. Participants with missing values for these confounders were excluded from the adjusted analysis.…”

Section: Discussionmentioning

confidence: 99%

Maternal dietary intake of vitamin A during pregnancy was inversely associated with congenital diaphragmatic hernia: the Japan Environment and Children’s Study

et al. 2019

View full text Add to dashboard Cite

The pathogenesis of congenital diaphragmatic hernia (CDH) is largely unknown; however, vitamin A seems to play a role in diaphragmatic development. Previous case–control studies reported that maternal dietary vitamin A intake was inversely associated with the risk of CDH. To our knowledge, however, there is no prospective evidence regarding this association. Our aim was to examine whether maternal intake of vitamin A was associated with CDH occurrence. Baseline data, from the Japan nationwide birth cohort study (2011–2014) of 89 658 mothers (mean age at delivery = 31·2 years) who delivered singleton live births, were analysed. We assessed dietary habits using an FFQ focused on the first trimester and estimated the daily intake of total vitamin A (retinol activity equivalents), retinol, provitamin A carotenoids and vegetables. The occurrence of CDH was ascertained from medical records. A total of forty cases of CDH were documented. The adjusted OR of CDH occurrence for the high total vitamin A intake category (median = 468 μg/d) was 0·6 (95 % CI 0·3, 1·2) with reference to the low intake category (230 μg/d). When we restricted to mothers with a prepregnancy BMI of 18·5–24·9 kg/m2, vitamin A intake was inversely associated with the risk of their children being born with CDH (OR 0·5, 95 % CI 0·2, 1·0). Even given the limited number of cases in the study, our findings provide additional evidence to link vitamin A with CDH.

show abstract

“…[11][12][13][14] Alcohol use and maternal pregestational diabetes are also significantly associated with CDH. 15 The diagnosis is usually achieved with imaging (ultrasound) in the prenatal period, 1,2 and the evolution of diagnostic techniques has dramatically decreased the number of cases found in post-natal period. 16 In the elderly, diaphragmatic hernias due to congenital etiology are detected with a frequency of 0.17-6%, being most often associated with acquired causes such as thoraco-abdominal injuries.…”

Section: Discussionmentioning

confidence: 99%

Orthopnea and fever in an elderly woman

Tana

Carlo

Silingardi³

et al. 2017

Ital J Med

View full text Add to dashboard Cite

Orthopnea is a sensation of shortness of breath, which occurs in recumbent position and is usually improved by standing or sitting. The authors report a case of an 81-year-old woman presented to the Emergency Department with a two-week history of orthopnea, fever and low back pain resistant to analgesics. Radiological findings confirm the presence of a diafragmatic hernia, and clinicians should pay attention to any history of trauma, because their absence in symptomatic adult patients directs towards a congenital cause. A surgical repair should be promptly obtained to avoid further general and respiratory deterioration.

show abstract

Maternal medical and behavioral risk factors for congenital diaphragmatic hernia

Cited by 20 publications

References 32 publications

Parental risk factors for congenital diaphragmatic hernia – a large German case-control study

Parental risk factors for congenital diaphragmatic hernia – a large German case-control study

Maternal dietary intake of vitamin A during pregnancy was inversely associated with congenital diaphragmatic hernia: the Japan Environment and Children’s Study

Orthopnea and fever in an elderly woman

Contact Info

Product

Resources

About