Maternal inheritance of atopic IgE responsiveness on chromosome 11 q

Cookson, William; Young, R. P.; Sandford, Andrew J.; Moffatt, Miriam F.; Shirakawa, Taro; Sharp, P. A.; Faux, J. A.; Souëf, P. Le; Julier, Cécile; Lathrop, G.M.; Nakumura, Y; Hopkin, Julian M.

doi:10.1016/0140-6736(92)91468-n

Cited by 332 publications

(185 citation statements)

References 25 publications

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“…This latter observation, although not significant on its own, is consistent with previously published evidence of excess sharing of maternal alleles at asthma susceptibility loci, [26][27][28] including markers flanking IL4RA. 29 There was no evidence that the potential disease association of À3223 C4T differed between the six populations (not shown).…”

Section: Resultssupporting

confidence: 91%

Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene

et al. 2003

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Variations in the interleukin 4 receptor A (IL4RA) gene have been reported to be associated with atopy, asthma, and allergy, which may occur less frequently in subjects with type 1 diabetes (T1D). Since atopy shows a humoral immune reactivity pattern, and T1D results from a cellular (T lymphocyte) response, we hypothesised that alleles predisposing to atopy could be protective for T1D and transmitted less often than the expected 50% from heterozygous parents to offspring with T1D. We genotyped seven exonic single nucleotide polymorphisms (SNPs) and the -3223 C4T SNP in the putative promoter region of IL4RA in up to 3475 T1D families, including 1244 Finnish T1D families. Only the À3223 C4T SNP showed evidence of negative association (P ¼ 0.014). There was some evidence for an interaction between À3233 C4T and the T1D locus IDDM2 in the insulin gene region (P ¼ 0.001 in the combined and P ¼ 0.02 in the Finnish data set). We, therefore, cannot rule out a genetic effect of IL4RA in T1D, but it is not a major one.

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Section: Resultssupporting

confidence: 91%

Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene

et al. 2003

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show abstract

“…Here, the transmission of atopy at the chromosome 11q locus is detectable only through the maternal line, because no excess sharing of paternally derived alleles was seen. The pattern of inheritance is consistent either with paternal genomic imprinting or with maternal modification of developing immune responses (42).…”

Section: Maternal/paternal Inheritancementioning

confidence: 66%

Atopic eczema/dermatitis syndrome – a genetically complex disease. New advances in discovering the genetic contribution

Klüken¹,

Wienker

Bieber³

2003

Allergy

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“…Le chromosome Ilql3 a été décrit comme une région génétique liée à l'atopie pour la première fois en 1989 par Cookson et ses collègues (Cookson et al, 1992). Les études d'association qui s'en suivirent montrèrent que le gène du récepteur de haute affinité pour le IgE (FCERIB) est localisé dans cette région et que certains variants étaient associés à l'asthme (Shirakawa et al, 1996).…”

Section: Atopieunclassified

Étude d'association entre certains gènes candidats et l'asthme dans une cohorte familiale originaire du Saguenay-Lac-Saint-Jean :

Tremblay¹

2003

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Maternal inheritance of atopic IgE responsiveness on chromosome 11 q

Cited by 332 publications

References 25 publications

Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene

Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene

Atopic eczema/dermatitis syndrome – a genetically complex disease. New advances in discovering the genetic contribution

Étude d'association entre certains gènes candidats et l'asthme dans une cohorte familiale originaire du Saguenay-Lac-Saint-Jean :

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