Maternal high fat diet during the perinatal period alters mesocorticolimbic dopamine in the adult rat offspring: reduction in the behavioral responses to repeated amphetamine administration

Abstract

Our results demonstrate that both synthetic activity in VTA neurons and the responsiveness of accumbens DA neurons is altered by maternal nutrition. These effects subside long after termination of exposure to the HF diet.

Maternal “junk‐food” feeding of rat dams alters food choices and development of the mesolimbic reward pathway in the offspring

“…This pattern of gene expression is consistent with reduced sensitivity to opioids and increased reuptake of dopamine into the presynaptic neuron and therefore collectively indicates reduced opioid and dopamine signaling. These results are also consistent with previous studies that have reported reduced sensitivity to amphetamine‐induced loco‐motor activity and increased dopamine content within the NAc in the adult offspring of high‐fat‐fed mice, which provided evidence for the desensitization of dopamine receptors (45). Similarly, Vucetic et al (10) reported that offspring of dams fed a high‐fat diet had reduced dopamine signaling, as demonstrated by reduced expression of D1 and D2 receptors and increased DAT expression at 6 mo of age.…”

Maternal “junk‐food” feeding of rat dams alters food choices and development of the mesolimbic reward pathway in the offspring

“…This pattern of gene expression is consistent with reduced sensitivity to opioids and increased reuptake of dopamine into the presynaptic neuron and therefore collectively indicates reduced opioid and dopamine signaling. These results are also consistent with previous studies that have reported reduced sensitivity to amphetamine‐induced loco‐motor activity and increased dopamine content within the NAc in the adult offspring of high‐fat‐fed mice, which provided evidence for the desensitization of dopamine receptors (45). Similarly, Vucetic et al (10) reported that offspring of dams fed a high‐fat diet had reduced dopamine signaling, as demonstrated by reduced expression of D1 and D2 receptors and increased DAT expression at 6 mo of age.…”

Eating high fat chow increases the sensitivity of rats to 8-OH-DPAT-induced lower lip retraction

“…Thus, eating high fat chow markedly alters sensitivity to the behavioral effects of drugs acting directly on 5-HT or dopamine systems and those changes appear to persist even when rats no longer have access to high fat chow. These results are consistent with studies showing that in rats maternal consumption of high fat chow during the perinatal period induces long lasting effects in dopamine function and in the behavior of adult offspring (Naef et al, 2007). …”

Maternal high-fat diet and obesity impact palatable food intake and dopamine signaling in nonhuman primate offspring

“…Deterioration of cortico‐cortical communication observed here may lead to problems with integration , such as sensory information from food, with motor onset to obtain more food. In contrast to our findings, a rodent study observed no impairments in the abundance of PFC‐TH proteins in offspring from HFD‐fed mothers . Differences between these results could be attributed to the NHP PFC being more complex or due to different diet composition.…”

Maternal “junk‐food” feeding of rat dams alters food choices and development of the mesolimbic reward pathway in the offspring

“…This pattern of gene expression is consistent with reduced sensitivity to opioids and increased reuptake of dopamine into the presynaptic neuron and therefore collectively indicates reduced opioid and dopamine signaling. These results are also consistent with previous studies that have reported reduced sensitivity to amphetamine‐induced loco‐motor activity and increased dopamine content within the NAc in the adult offspring of high‐fat‐fed mice, which provided evidence for the desensitization of dopamine receptors (45). Similarly, Vucetic et al (10) reported that offspring of dams fed a high‐fat diet had reduced dopamine signaling, as demonstrated by reduced expression of D1 and D2 receptors and increased DAT expression at 6 mo of age.…”

Eating high fat chow increases the sensitivity of rats to 8-OH-DPAT-induced lower lip retraction

“…Thus, eating high fat chow markedly alters sensitivity to the behavioral effects of drugs acting directly on 5-HT or dopamine systems and those changes appear to persist even when rats no longer have access to high fat chow. These results are consistent with studies showing that in rats maternal consumption of high fat chow during the perinatal period induces long lasting effects in dopamine function and in the behavior of adult offspring (Naef et al, 2007). …”

Maternal high-fat diet and obesity impact palatable food intake and dopamine signaling in nonhuman primate offspring

“…Deterioration of cortico‐cortical communication observed here may lead to problems with integration , such as sensory information from food, with motor onset to obtain more food. In contrast to our findings, a rodent study observed no impairments in the abundance of PFC‐TH proteins in offspring from HFD‐fed mothers . Differences between these results could be attributed to the NHP PFC being more complex or due to different diet composition.…”

Maternal “junk‐food” feeding of rat dams alters food choices and development of the mesolimbic reward pathway in the offspring

“…This pattern of gene expression is consistent with reduced sensitivity to opioids and increased reuptake of dopamine into the presynaptic neuron and therefore collectively indicates reduced opioid and dopamine signaling. These results are also consistent with previous studies that have reported reduced sensitivity to amphetamine‐induced loco‐motor activity and increased dopamine content within the NAc in the adult offspring of high‐fat‐fed mice, which provided evidence for the desensitization of dopamine receptors (45). Similarly, Vucetic et al (10) reported that offspring of dams fed a high‐fat diet had reduced dopamine signaling, as demonstrated by reduced expression of D1 and D2 receptors and increased DAT expression at 6 mo of age.…”

Eating high fat chow increases the sensitivity of rats to 8-OH-DPAT-induced lower lip retraction

“…Thus, eating high fat chow markedly alters sensitivity to the behavioral effects of drugs acting directly on 5-HT or dopamine systems and those changes appear to persist even when rats no longer have access to high fat chow. These results are consistent with studies showing that in rats maternal consumption of high fat chow during the perinatal period induces long lasting effects in dopamine function and in the behavior of adult offspring (Naef et al, 2007). …”

Maternal high-fat diet and obesity impact palatable food intake and dopamine signaling in nonhuman primate offspring

“…Deterioration of cortico‐cortical communication observed here may lead to problems with integration , such as sensory information from food, with motor onset to obtain more food. In contrast to our findings, a rodent study observed no impairments in the abundance of PFC‐TH proteins in offspring from HFD‐fed mothers . Differences between these results could be attributed to the NHP PFC being more complex or due to different diet composition.…”