Maternal fish oil consumption has a negative impact on mammary gland tumorigenesis in C3(1) Tag mice offspring

Ion, Gabriela; Akinsete, Juliana A.; Witte, Theodore R.; Bostan, Marinela; Hardman, W. Elaine

doi:10.1007/s00394-021-02546-8

Cited by 2 publications

(23 citation statements)

References 43 publications

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“…and NF-κB) in the mammary gland of offspring [45]. These results, and similar ones obtained with wild-type C57BL/6J mice or transgenic C3(1) Tag mice, highlighted the influence of the mother's diet on the occurrence and development of breast cancer in her offspring [45][46][47][48]. The molecular mechanisms of this protective effect of n-3 LC-PUFAs are still poorly understood, but a recent study has shown the involvement of gut microbiota restructuring as a mechanism of maternal n-3 LC-PUFAs' protective effect against mammary tumors in offspring [47].…”

Section: Protective Effect Of Nutritional N-3 Lc-pufas Against Breast...supporting

confidence: 81%

Contribution of n-3 Long-Chain Polyunsaturated Fatty Acids to the Prevention of Breast Cancer Risk Factors

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Blanckaert

Ulmann

et al. 2022

IJERPH

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Nowadays, diet and breast cancer are studied at different levels, particularly in tumor prevention and progression. Thus, the molecular mechanisms leading to better knowledge are deciphered with a higher precision. Among the molecules implicated in a preventive and anti-progressive way, n-3 long chain polyunsaturated fatty acids (n-3 LC-PUFAs) are good candidates. These molecules, like docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids, are generally found in marine material, such as fat fishes or microalgae. EPA and DHA act as anti-proliferative, anti-invasive, and anti-angiogenic molecules in breast cancer cell lines, as well as in in vivo studies. A better characterization of the cellular and molecular pathways involving the action of these fatty acids is essential to have a realistic image of the therapeutic avenues envisaged behind their use. This need is reinforced by the increase in the number of clinical trials involving more and more n-3 LC-PUFAs, and this, in various pathologies ranging from obesity to a multitude of cancers. The objective of this review is, therefore, to highlight the new elements showing the preventive and beneficial effects of n-3 LC-PUFAs against the development and progression of breast cancer.

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Section: Protective Effect Of Nutritional N-3 Lc-pufas Against Breast...supporting

confidence: 81%

Contribution of n-3 Long-Chain Polyunsaturated Fatty Acids to the Prevention of Breast Cancer Risk Factors

Fodil

Blanckaert

Ulmann

et al. 2022

IJERPH

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“…The eligibility analysis excluded a further five articles—three studies reported only in vitro results and two did not use the BC model. Thus, only 27 unduplicated full-text articles [ 17 , 18 , 19 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 ] were included in this systematic review, 19 from PubMed and 8 from Scopus, as shown in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

“…The breast tumor experimental model most used in the selected studies was the conventional tumor cell transplant in specific tissue regions of animal models (69%) [ 17 , 18 , 19 , 39 , 42 , 43 , 45 , 46 , 49 , 50 , 51 , 53 , 55 , 57 , 58 , 59 , 60 , 61 , 62 ], followed by the model of spontaneous tumor generation using transgenic animals (17%) [ 40 , 41 , 47 , 52 , 55 , 56 ], and lastly, 14% of studies induced BC in the animal model by carcinogenic drug transplant [ 44 , 48 , 54 ].…”

Section: Resultsmentioning

confidence: 99%

“…All studies utilized the in vivo murine model—93% mice [ 17 , 18 , 19 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 49 , 50 , 51 , 52 , 53 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 ] and 7% in rats [ 48 , 54 ]. The breast tumor model by cell transplant was performed in 64% of studies using different cell sources, 70% from humans [ 17 , 18 , 19 , 45 , 49 , 50 , 51 , 53 , 55 , 58 , 59 , 60 , 61 , 62 ] and 30% from mice [ 39 , 42 , 43 , 46 , 53 , 57 ], and in 17% of studies, transgenic animals developed the tumor spontaneously [ 40 , 41 , 47 , …”

Section: Resultsmentioning

confidence: 99%

“…The study by Liu [ 46 ] used C57BL/6 mice and compared two different genotypes of adipose fatty acid binding protein-deficient mice (A-FABP −/− ) with the wildtype, and the study by Li [ 52 ] used the offspring of the wild-genotype mice from Fat-1 and C57BL/6 crossing for the tumoral chemical induction model, totaling 11% of the selected studies [ 42 , 46 , 52 ]. The remaining 18% of the studies used transgenic mice [ 40 , 41 , 47 , 55 , 56 ], of which 80% were obtained from crossing the FVB/N mice with the mammary tumor virus (MMTV), so that these mice had the MMTV- Neu ndl YD5 genotype [ 40 , 47 , 56 ], with only one having the FVB/N-Tg(MMTV-PyVT)634Mul genotype [ 55 ]; 20% were obtained from crossing the SV129 mice with the c(3)1-Tag, using the hemizygous pups’ genotype [ 41 ].…”

Section: Resultsmentioning

confidence: 99%

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The Effects of Omega-3 Polyunsaturated Fatty Acids on Breast Cancer as a Preventive Measure or as an Adjunct to Conventional Treatments

et al. 2023

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In order to understand how omega-3 polyunsaturated fatty acid (ω-3 PUFA) supplements affect breast cancer prevention and treatment, a systematic review of articles published in the last 5 years in two databases was performed. Of the 679 articles identified, only 27 were included and examined based on five topics, taking into account: the induction type of the breast cancer used in animal models; the characteristics of the induction model by cell transplantation; the experimental design of the ω-3 supplementation—combined or not with a treatment antitumor drug; the fatty acids (FAs) composition used; the analysis of the studies’ outcomes. There are diverse and well-established animal models of breast cancer in the literature, with very relevant histological and molecular similarities depending on the specific objective of the study, such as whether the method of tumor induction was transgenic, by cell transplantation, or by oncogenic drugs. The analyses of outcomes were mainly focused on monitoring tumor growth, body/tumor weight, and molecular, genetic, or histological analyses, and few studies evaluated latency, survival, or metastases. The best results occurred when supplementation with ω-3 PUFA was associated with antitumor drugs, especially in the analysis of metastases and volume/weight of tumors or when the supplementation was started early and maintained for a long time. However, the beneficial effect of ω-3 PUFA supplementation when not associated with an antitumor agent remains unclear.

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Maternal fish oil consumption has a negative impact on mammary gland tumorigenesis in C3(1) Tag mice offspring

Cited by 2 publications

References 43 publications

Contribution of n-3 Long-Chain Polyunsaturated Fatty Acids to the Prevention of Breast Cancer Risk Factors

Contribution of n-3 Long-Chain Polyunsaturated Fatty Acids to the Prevention of Breast Cancer Risk Factors

The Effects of Omega-3 Polyunsaturated Fatty Acids on Breast Cancer as a Preventive Measure or as an Adjunct to Conventional Treatments

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