Maternal exposure to the CB1 cannabinoid agonist WIN 55212–2 produces robust changes in motor function and intrinsic electrophysiological properties of cerebellar Purkinje neurons in rat offspring

Shabani, Mohammad; Hosseinmardi, Narges; Haghani, Masoud; Shaibani, V.; Janahmadi, Mahyar

doi:10.1016/j.neuroscience.2010.10.031

Cited by 56 publications

(45 citation statements)

References 81 publications

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“…CB 1 receptor expression is abundant in several brain regions including the hippocampus, prefrontal cortex, nucleus accumbens and amygdala where their modulation of neurotransmitter release exerts a variety of behavioral and cognitive effects (Khan, Maalik, 2013). Here, a substantial body of evidence from animal models and human studies has shown that CB 1 receptor agonists, frequently in the form of ∆ 9 -tetrahydrocannabinol which is the principal psychoactive component derived from Cannabis sativa, induce numerous and complex effects on cognitive functions including attention, learning, emotional reactivity, enhancement of the perceptions of the senses, and, idiosyncratically, impairment and improvement in short-term memory (Barzegar et al , 2015, Razavinasab et al , 2013, Shabani et al , 2009, Shabani et al , 2011. In the passive avoidance task, CB 1 receptor activation reversed opioid-induced memory impairment (Zarrindast, 2006) but in other reports have been shown to impair passive avoidance learning in addition to adversely affecting spatial and working memory (Hasanein andTeimuri Far, 2015, Shabani et al , 2012).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Cannabinoid receptor agonism suppresses tremor, cognition disturbances and anxiety-like behaviors in a rat model of essential tremor

Abbassian

Esmaeili

Tahamtan

et al. 2016

Physiology & Behavior

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Cognitive and motor disturbances are serious consequences of tremor induced by motor disorders. Despite a lack of effective clinical treatment, some potential therapeutic agents have been used to alleviate the cognitive symptoms in the animal models of tremor. In the current study, the effects of WIN55, 212-2 (WIN), a cannabinoid receptor (CBR) agonist, on harmaline-induced motor and cognitive impairments were studied. Adult rats were treated with WIN (0.5mg/kg; i.p.) 15min before harmaline administration (10mg/kg; ip) after which exploratory and anxiety related behaviors, and cognitive function were assessed using open-field behavior and shuttle box tests. Rats that received harmaline only exhibited a markedly reduced number of central square entries when compared to harmaline vehicle-treated controls, whereas those treated with WIN and harmaline showed a significant increase in central square entries, compared to harmaline only treated. The passive avoidance memory impairments observed in harmaline treated rats, was reversed somewhat by administration of WIN. The neuroprotective and anxiolytic effects of WIN demonstrated in the current study can be offered cannabinoid receptor (CBR) agonism as a potential neuroprotective agent in the treatment of patients with tremor that manifest mental dysfunctions.

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Section: Accepted Manuscriptmentioning

confidence: 99%

Cannabinoid receptor agonism suppresses tremor, cognition disturbances and anxiety-like behaviors in a rat model of essential tremor

Abbassian

Esmaeili

Tahamtan

et al. 2016

Physiology & Behavior

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“…Whole-cell recordings were made as described previously [26]. Slices were transferred to a submerged recording chamber on the stage of an upright microscope (Olympus; BX 51WI).…”

Section: Whole-cell Patch Clamp Recordingmentioning

confidence: 99%

“…The direct activation of voltage-gated K + channels, including fast transient (A-type) and large conductance Ca 2+ -activated K + channels by cannabinoids, has also been reported [25,26].…”

Section: Introductionmentioning

confidence: 96%

CB1 Cannabinoid Receptor Activation Rescues Amyloid ß-Induced Alterations in Behaviour and Intrinsic Electrophysiological Properties of Rat Hippocampal CA1 Pyramidal Neurones

Haghani

Shabani

Javan

et al. 2012

Cell Physiol Biochem

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Background: Amyloid beta (Aβ) is believed to be responsible for the synaptic failure that occurs in Alzheimer′s disease (AD), but there is little known about the functional impact of Aβ on intrinsic neuronal properties. Here, the cellular effect of Aβ-induced neurotoxicity on the electrophysiological properties of CA1 pyramidal neurons and the mechanism(s) of neuroprotection by CB1 cannabinoid receptor activation was explored. Methods: A combination of behavioural, molecular and electrophysiological approaches was used. Results: Bilateral injections of the Aβ peptide fragment (1-42) into the prefrontal cortex caused a significant impairment in the retention and recall capability in the passive avoidance tasks and significantly increased the level of active caspase-3 in the hippocampus. Whole-cell patch clamp recordings revealed a significant reduction in the intrinsic action potential (AP) frequency and an increase in the discharge irregularity in the absence of synaptic inputs in Aβ treated group. Aβ treatment induced also significant changes in both the spontaneous and evoked neuronal responses. However, co-treatment with ACEA, a CB1 receptor agonist, preserved almost the normal intrinsic electrophysiological properties of pyramidal cells. Conclusions: In vivo Aβ treatment altered significantly the intrinsic electrophysiological properties of CA1 pyramidal neurons and the activation of CB1 cannabinoid receptors exerted a strong neuroprotective action against Aβ toxicity.

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“…Another study applying behavioral assays, extracellular field potential recordings and whole-cell patch clamp recordings investigated the maternal exposure to the CB1 cannabinoid receptor agonist WIN 55-212-2 (WIN) in rats [32]. Treated pregnant rats showed a significant decrease in the rearing frequency, total distance moved and mobility of the offspring, but they showed a significant increase in the righting reflex time, the grooming frequency and immobility.…”

Section: Marijuana (Cannabis Sativa)mentioning

confidence: 99%

Herbal laxatives and antiemetics in pregnancy

Samavati

Ducza

Hajagos-Tóth

et al. 2017

Reproductive Toxicology

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a b s t r a c tConstipation appears in the 2nd and 3rd trimester of pregnancy, while nausea is the strongest in the 1st trimester. This review summarizes the applicability of herbal laxatives and antiemetics in pregnancy.A human study has shown that flax oil as laxative is safe from 2nd trimester. Human data is not available about the rhubarb, but animal studies reveal that its emodin content induces fetal abnormalities. Fenugreek induces teratogenic malformation both in human and animals. Senna seed is proved as a safe laxative in pregnancy. The antiemetic ginger is safe during 1st trimester, but it reduces the gestational period when applied from the 2nd trimester. Cannabis induces fetal neurological disorders while fennel can shorten the gestational age.There is herbal alternative for laxative therapy (senna) for the whole length of pregnancy, but nausea and vomiting might be reduced by herbal medicine (ginger) safely in the 1st trimester, only.

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Maternal exposure to the CB1 cannabinoid agonist WIN 55212–2 produces robust changes in motor function and intrinsic electrophysiological properties of cerebellar Purkinje neurons in rat offspring

Cited by 56 publications

References 81 publications

Cannabinoid receptor agonism suppresses tremor, cognition disturbances and anxiety-like behaviors in a rat model of essential tremor

Cannabinoid receptor agonism suppresses tremor, cognition disturbances and anxiety-like behaviors in a rat model of essential tremor

CB1 Cannabinoid Receptor Activation Rescues Amyloid ß-Induced Alterations in Behaviour and Intrinsic Electrophysiological Properties of Rat Hippocampal CA1 Pyramidal Neurones

Herbal laxatives and antiemetics in pregnancy

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