Maternal exposure to cadmium during gestation perturbs the vascular system of the adult rat offspring

Ronco, Ana María; Montenegro, M. A.; Castillo, Paula; Urrutia, Miguel; Saez, Daniel Martinez; Hirsch, Sandra; Zepeda, Ramiro; Llanos, Miguel

doi:10.1016/j.taap.2011.01.001

Cited by 38 publications

(41 citation statements)

References 63 publications

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“…In particular, high susceptibility of the heart to cadmium was reported in a human 15 year follow-up study in line with the fact that the heart is a relatively sensitive organ due to its low anti-oxidant capacity [7]. Similarly, animal studies also shows cadmium cause some changes in cardiovascular functions [8][9][10]. Environmental exposure to cadmium has been found to be associated with an increased prevalence of heart failure, although the precise toxic effects of cadmium exposure on myocardial function remain unknown [11].…”

Section: Introductionmentioning

confidence: 72%

Effects of age, gender, BMI, settlement and smoking on lead and cadmium accumulation in heart tissue

Dip¹,

İritaş²,

Mergen³

et al. 2017

Med-Science

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Cadmium (Cd) and lead (Pb) are well-known risk factors for peripheral arterial and some other cardiovascular diseases. The aim of the study was to determine the level of both toxic metals, in the human heart tissue and compare the accumulation to their age, gender, body mass index, living environment and smoking habit. Heart tissues of the 112 autopsy cases, representing a sample set of population living in capital city of Turkey: Ankara Province (both in city center and suburban), were collected from Turkey Ministry of Justice, Council of Forensic Medicine in Ankara Branch. Lead and cadmium analysis was carried out by Graphite Furnace Atomic Spectrometry technique. Cd/Pb results and individuals' information were assessed by SPSS statistically. Average value of Pb was found as 1374.99±237.01ppb and Cd was found as 287.54±66.43ppb in all heart tissue samples. Consideration of metal levels in autopsy heart tissues by age, statistically significant positive correlation in Cd was observed (p<0.05). There was no correlation found between metal levels with gender and BMI values. Both Pb and Cd levels of the samples who lived in urban was significantly greater than in suburban areas (p<0.05). Significant increase Cd level were observed in smokers' heart tissues (p<0.05), however, contrary to expectations, Pb has no statistically significant result.

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Section: Introductionmentioning

confidence: 72%

Effects of age, gender, BMI, settlement and smoking on lead and cadmium accumulation in heart tissue

Dip¹,

İritaş²,

Mergen³

et al. 2017

Med-Science

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“…Mechanistic evidence has linked cadmium to atherosclerosis development, [4][5][6]36 and cross-sectional studies have also evidenced an increased prevalence of atherosclerotic vascular disease with increased cadmium exposure in the US general population 21,22 and in populations from other countries. 6,17,23 Our results add prospective evidence of the importance of cadmium exposure as a risk factor for the development of PAD.…”

Section: Discussionmentioning

confidence: 99%

“…[4][5][6]57 Cadmium could also act through epigenetic 58 and endocrine disruption [59][60][61] pathways. The mechanistic studies add biological plausibility to the evidence from studies in human populations, suggesting a doseresponse relationship in the association between cadmium exposure and PAD.…”

Section: Discussionmentioning

confidence: 99%

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Cadmium Exposure and Incident Peripheral Arterial Disease

Téllez-Plaza

Güallar

Fabsitz

et al. 2013

Circ: Cardiovascular Quality and Outcomes

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Background-Cadmium has been associated with peripheral arterial disease (PAD) in cross-sectional studies, but prospective evidence is lacking. Our goal was to evaluate the association of urine cadmium concentrations with incident PAD in a large population-based cohort. Methods and Results-A prospective cohort study was performed with 2864 adult American Indians 45 to 74 years of age from Arizona, Oklahoma, and North and South Dakota who participated in the Strong Heart Study from 1989 to 1991 and were followed through 2 follow-up examination visits in 1993 to 1995 and 1997 to 1999. Participants were free of PAD, defined as an ankle brachial index <0.9 or >1.4 at baseline, and had complete baseline information on urine cadmium, potential confounders, and ankle brachial index determinations in the follow-up examinations. Urine cadmium was measured using inductively coupled plasma mass spectrometry and corrected for urinary dilution by normalization to urine creatinine. Multivariable-adjusted hazard ratios were computed using Cox-proportional hazards models for interval-censored data. A total of 470 cases of incident PAD, defined as an ankle brachial index <0.9 or >1.4, were identified. After adjustment for cardiovascular disease risk factors including smoking status and pack-years, the hazard ratio comparing the 80th to the 20th percentile of urine cadmium concentrations was 1.41 (1.05-1.81). The hazard ratio comparing the highest to the lowest tertile was 1.96 (1.32-2.81). The association persisted after excluding participants with ankle brachial index >1.4 only as well as in subgroups defined by sex and smoking status. Conclusions-Urine cadmium, a biomarker of long-term cadmium exposure, was independently associated with incident PAD, providing further support for cadmium as a cardiovascular disease risk factor. (Circ Cardiovasc Qual Outcomes. 2013;6:626-633.)

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“…We have recently reported that exposure of pregnant rats to 30 ppm of Cd 2? induces a reduction in the endotheliumdependent activity and a concentric ventricular hypertrophy in the adult offspring, even if Cd 2? was not detected in the analyzed tissues at various age periods [8]. These results, together with increased NF-kB expression in placental tissues, suggest that molecular events induced by Cd 2?…”

Section: Introductionmentioning

confidence: 73%

Cardiac Tissue Injury Resistance During Myocardial Infarction at Adulthood by Developmental Exposure to Cadmium

et al. 2011

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It has been suggested that prenatal exposure to cadmium may alter the cardiovascular function during adulthood. Using the left coronary artery ligation model of acute myocardial infarction, we studied the cardiac function of female adult offspring rats exposed to cadmium (30 ppm) during gestation. The cardiac ischemic zone in the control and cadmium-exposed groups was measured 72 h post-ligation using the TPT staining technique. Offspring from cadmium-treated dams showed a significantly smaller infarcted area compared with the control group (7.1 ± 1.5 vs. 19.6 ± 2.8%, P ≤ 0.05). We also performed echocardiographic and biochemical studies, which positively correlated with the differences observed previously. To evaluate whether the effects were associated to pre-infarct tissue damage and/or angiogenic molecules, we performed histological studies and measured the expression of vascular endothelial growth factor (VEGF), and platelet endothelial cellular adhesion molecule-1 (PECAM-1). Results revealed a higher heart vascularization in the exposed offspring that was associated with an increase in PECAM and a decrease in VEGF expression. We conclude that prenatal exposure to cadmium induces fetal adaptive responses involving changes in the expression of some cardiac angiogenic molecules resulting in long-term resistance to infarction.

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Maternal exposure to cadmium during gestation perturbs the vascular system of the adult rat offspring

Cited by 38 publications

References 63 publications

Effects of age, gender, BMI, settlement and smoking on lead and cadmium accumulation in heart tissue

Effects of age, gender, BMI, settlement and smoking on lead and cadmium accumulation in heart tissue

Cadmium Exposure and Incident Peripheral Arterial Disease

Cardiac Tissue Injury Resistance During Myocardial Infarction at Adulthood by Developmental Exposure to Cadmium

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