1988
DOI: 10.1037/0278-6133.7.2.125
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Abstract: Cross-fostering spontaneously hypertensive rat (SHR) pups to Wistar-Kyoto (WKY) normotensive mothers influenced physical development, resting mean arterial pressure and heart rate, open-field behavior, and sympathetic-adrenal medullary responses to stressors. In contrast, cross-fostering WKY pups to SHR mothers at birth did not affect these developmental processes.

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Cited by 13 publications
(14 citation statements)
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“…Whereas some research has demonstrated spontaneous hyperactivity in the SHR [22-27], other research has shown this effect only at certain ages [19,28], and still other research has not shown such an effect [29-31]. In contrast, operant hyperactivity is well demonstrated in the SHR [16,25,31-34].…”
Section: Introductionmentioning
confidence: 99%
“…Whereas some research has demonstrated spontaneous hyperactivity in the SHR [22-27], other research has shown this effect only at certain ages [19,28], and still other research has not shown such an effect [29-31]. In contrast, operant hyperactivity is well demonstrated in the SHR [16,25,31-34].…”
Section: Introductionmentioning
confidence: 99%
“…First, the link between specific motivation-related neural mechanisms and performance is better characterized in open-field locomotion [33] than in rotational behavior, despite the well-established involvement of mesolimbic dopamine activity in the latter [49]. Second, although open-field hyperlocomotion has been demonstrated in SHR of a wide range of ages (e.g., [53,54]), this study only demonstrated cross-strain similarities in the rotational behavior of 101-day old rats. These limitations notwithstanding, rotational behavior appears to provide an alternative approach to study behavioral-activational effects in the SHR model, that are obscured by baseline differences in performance relative to WKY.…”
Section: Discussionmentioning
confidence: 99%
“…Although differences in behavioral traits between rat strains generally result from genetic variations, environmental factors during postnatal development play a meaningful role in physiological [6,7,24,25,34] and behavioral [1,15,22] differences. One way to estimate the impact of early life environment on a phenotype is by cross-fostering.…”
Section: Discussionmentioning
confidence: 99%
“…In the postnatal period, the maternal environment has a major impact on pups, and maternal deprivation and cross-fostering to another strain that has a different phenotype is often employed to determine the influence of early life experiences on the development of pups. A series of studies carried out with genetic models of hypertension, spontaneous hypertensive rats (SHRs), indicated that the development of high blood pressure in SHRs was abolished by cross-fostering to normotensive mothers [6,7,24,25] and that the influence of the maternal environment was limited to the first 2 weeks of postnatal life [23], suggesting that an interaction of genetic predispositions with early environmental factors results in the expression of the adult phenotype. The aim of the present study was to examine the influence of maternal environment on behavioral traits under different situations, and to determine the behavioral characteristics of inbred strain F344 rats in detail.…”
Section: Introductionmentioning
confidence: 99%