Maternal diabetes impairs the initiation of meiosis in murine female germ cells

Qiu, Xueting; Li, Meiling; Li, Ng; Sun, Qiang; Zhou, Ji; Ma, Rujun; Lin, Ying; Xie, Min; Ge, Xie; Chen, Li; Yao, Bing

doi:10.3892/mmr.2017.7245

Cited by 8 publications

(4 citation statements)

References 24 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Female rats born to mothers fed a high-fat diet throughout pregnancy have fewer oocytes in fetal ovaries at embryonic day 20 and it was speculated that increased maternal-fetal inflammation associated with maternal obesity ( Aye et al ., 2014 ) may have contributed to accelerated fetal oocyte loss ( Tsoulis et al ., 2016 ). In a murine pharmacological model of maternal diabetes induced by streptozotocin administration, in utero exposure of mice to hyperglycemia decreases the expression of genes involved in meiosis initiation ( Stra8, Dmc1 and Sycp3 ) and germ cell cyst breakdown ( Nobox, Figla and Bmp15 ) and impairs the initiation of meiosis and follicle assembly in the fetal offspring ovaries ( Qiu et al ., 2017 ). The starvation of mouse pups between 1.5 and 3 days of postnatal life, when most primordial follicles are assembling, leads also to a decrease in the expression of Nobox and the impairment of germ cell cyst breakdown; in the ovaries of the starved pups, the alteration of metabolic parameters, exemplified by the lower expression of genes encoding proteins of fatty acid synthesis such as Fabp5, Cpt2 and Acsl3 , could have triggered an oxidative stress responsible for the increased autophagy and apoptosis observed in the oocytes within cysts and in the primordial follicles ( Wang et al ., 2017 ).…”

Section: Nutritional Factorsmentioning

confidence: 99%

Factors influencing establishment of the ovarian reserve and their effects on fertility

Monniaux¹

2018

Anim Reprod

View full text Add to dashboard Cite

A reserve of primordial follicles is set up in the ovaries of fetuses or neonates, depending on the species, and serves as the source of developing follicles throughout the reproductive lifespan. This review focuses on the cellular and molecular mechanisms currently known to control the establishment of this reserve, and their regulation by environmental factors. Most mutations in genes controlling germ cell proliferation and survival, meiosis or follicle assembly lead to the absence of primordial follicles or a sharp reduction in their number, incompatible with fertility in adults. Inadequate maternal nutrition affects the cellular metabolism, increases the oxidative stress and delays follicle formation in fetal ovaries. Despite the existence of compensation mechanisms of some developmental processes, the early-life nutritional environment imprints the long-term ability of follicles to enter growth and develop in adult ovaries. However, maternal undernutrition, overfeeding or high-fat diet during the establishment of the ovarian reserve does not seem to affect the fertility of the female offspring, unless their metabolism or neuroendocrine status is altered. Exposure of fetal or neonatal ovaries to excess steroids inhibits or stimulates follicle formation in a complex manner depending on the nature of the steroid, the dose and the animal species. Estrogens can control follicle formation through intra-ovarian mechanisms involving members of the TGF-beta family such as activin and BMP2. Early-life exposure to synthetic estrogens or environmental pollutants with estrogen-like activity impairs meiotic progression and follicle assembly, and affects long-term primordial follicle activation in adult ovaries. The effects of compounds with estrogen-like activity on the ovarian reserve can be transmitted to several generations through the female germline. Further investigations are needed to establish the earlylife effects of the environmental factors on the female reproductive lifespan and decipher the mechanisms of their epigenetic effects on the size and quality of the ovarian reserve.

show abstract

Section: Nutritional Factorsmentioning

confidence: 99%

Factors influencing establishment of the ovarian reserve and their effects on fertility

Monniaux¹

2018

Anim Reprod

View full text Add to dashboard Cite

show abstract

“…As part of the mitochondrial uncoupling protein family, UCP2 plays an important role in energy regulation and is a negative regulator of insulin secretion [ 34 ]. Herein, UCP2 was found to be upregulated in IUGR piglets, suggesting that compared to NBW, IUGR animals are at a higher risk of developing diabetes [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Pituitary-Gland-Based Genes Participates in Intrauterine Growth Restriction in Piglets

Shen²,

Wu³

et al. 2022

Genes

View full text Add to dashboard Cite

Intrauterine growth restriction (IUGR) is a major problem associated with piglet growth performance. The incidence of IUGR is widespread in Rongchang pigs. The pituitary gland is important for regulating growth and metabolism, and research has identified genes associated with growth and development. The pituitary gland of newborn piglets with normal birth weight (NBW group, n = 3) and (IUGR group, n = 3) was collected for transcriptome analysis. A total of 323 differentially expression genes (DEGs) were identified (|log2(fold-change)| > 1 and q value < 0.05), of which 223 were upregulated and 100 were downregulated. Gene Ontology (GO) functional and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses showed that the DEGs were mainly related to the extracellular matrix, regulation of the multicellular organismal process, tissue development and angiogenesis, which participate in the growth and immune response in IUGR piglets. Moreover, 7 DEGs including IGF2, THBS1, ITGA1, ITGA8, EPSTI1, FOSB, and UCP2 were associated with growth and immune response. Furthermore, based on the interaction network analysis of the DEGs, two genes, IGF2 and THBS1, participated in cell proliferation, embryonic development and angiogenesis. IGF2 and THBS1 were also the main genes participating in the IUGR. This study identified the core genes involved in IUGR in piglets and provided a reference for exploring the effect of the pituitary gland on piglet growth.

show abstract

“…It has been previously reported that maternal nutrition and health throughout pregnancy (at the development time of the fetus ovary) can be considered agents that may affect oogonia proliferation and postnatal follicle reserve (7). Several studies have shown that maternal diabetes (28), starvation (18), mobile phone and Wi-Fi exposure (14), and estrogenic compounds (17) during pregnancy have negative effects on primordial follicles pool formation in female rat offspring. In this study, we found that maternal exercise during mid or late pregnancy was associated with higher numbers and diameters of primordial follicles.…”

Section: Discussionmentioning

confidence: 99%

Maternal aerobic running during mid or late gestation improves the quality of oogenesis and folliculogenesis in the ovary of neonatal rats: An experimental study

Yousefi¹,

Baradaran²,

Mokhtari³

et al. 2021

IJRM

View full text Add to dashboard Cite

Background: Regular maternal exercise in pregnancy enhances the physiological, metabolic, and psychological health of mother and fetus. Objective: To determine the effect of maternal aerobic running during mid or late gestation on plasma levels of estrogen and progesterone and the histological alterations in the ovary of neonatal rats. Materials and Methods: Twenty-one female Wistar rats were randomly divided into experimental groups to exercises during the 2nd or 3rd wk of pregnancy (n = 14) and a control group (n = 7). After birth, the neonate’s blood was obtained and the estrogen and progesterone levels were evaluated. The ovaries were then removed and used for histological investigations and apoptic assessment. Results: Higher concentrations of estrogen and progesterone were found in the neonates of the experimental groups (p = 0.001) compared to the control group. The experimental groups had a large ovarian diameter (2nd wk: p = 0.044; 3rd wk: p = 0.005) and angiogenesis (2nd wk: p = 0.003; 3rd wk: p = 0.001). In addition, significant enhancements were seen in the the experimental groups in terms of the number (2nd wk: p = 0.017; p = 0.035) and diameter (2nd wk: p = 0.046; 3rd wk: p = 0.004) of primordial follicles, as well as in the diameter of primary oocytes (2nd wk: p = 0.073; 3rd wk: p = 0.019) compared to the control group. Moreover, rats that exercised had a lower number of apoptotic primordial follicles than the control group (2nd wk: p = 0.001; 3rd wk: p = 0.001). Conclusion: It was shown that maternal aerobic running can lead to increased plasma levels of estrogen and progesterone, also improved histological characteristics of the ovary in neonatal rats. Key words: Apoptosis, Exercise, Neonatal, Oogenesis, Ovary, Rat.

show abstract

Maternal diabetes impairs the initiation of meiosis in murine female germ cells

Cited by 8 publications

References 24 publications

Factors influencing establishment of the ovarian reserve and their effects on fertility

Factors influencing establishment of the ovarian reserve and their effects on fertility

Pituitary-Gland-Based Genes Participates in Intrauterine Growth Restriction in Piglets

Maternal aerobic running during mid or late gestation improves the quality of oogenesis and folliculogenesis in the ovary of neonatal rats: An experimental study

Contact Info

Product

Resources

About