Maternal buspirone protects against the adverse effects of in utero stress on emotional and pain-related behaviors in offspring

Butkevich, I. P.; Mikhailenko, V. A.; Vershinina, E. A.; Semionov, P.O.; Makukhina, G. V.; Otellin, V. A.

doi:10.1016/j.physbeh.2010.10.023

Cited by 19 publications

(14 citation statements)

References 63 publications

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“…Stress exposure in preterm born children affects their HPA-axis response to painful immunization [44] and their HPA system dysfunction has been related to mother behavior [45]. Previous preclinical work has also shown that maternal restraint stress increases inflammatory pain hypersensitivity in newborn and adult offspring [7], [46]. Thus, in contrast to our study, maternal stress has been shown to increase pain sensitivity.…”

Section: Discussioncontrasting

confidence: 94%

“…No other studies have investigated the effects of developmental SSRI exposure on post-operative hypersensitivity to pain or the long-term impact of perinatal SSRI exposure on pain sensitivity in any regard. However, developmental exposure to buspirone, a 5-HT1A receptor agonist, was shown to normalize the increased pain hypersensitivity in prenatally stressed adult offspring [7]. More research is needed to investigate how children, prenatally exposed to SSRIs, respond to painful stimuli in later life.…”

Section: Discussionmentioning

confidence: 99%

“…Preclinical work has shown that perinatal maternal stress results in increased pain sensitivity in adult rat offspring [6], [7]. Underlying mechanisms for such long-term effects of maternal adversity on nociception in later life are rather unknown.…”

Section: Introductionmentioning

confidence: 99%

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Developmental Fluoxetine Exposure Normalizes the Long-Term Effects of Maternal Stress on Post-Operative Pain in Sprague-Dawley Rat Offspring

et al. 2013

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Early life events can significantly alter the development of the nociceptive circuit. In fact, clinical work has shown that maternal adversity, in the form of depression, and concomitant selective serotonin reuptake inhibitor (SSRI) treatment influence nociception in infants. The combined effects of maternal adversity and SSRI exposure on offspring nociception may be due to their effects on the developing hypothalamic-pituitary-adrenal (HPA) system. Therefore, the present study investigated long-term effects of maternal adversity and/or SSRI medication use on nociception of adult Sprague-Dawley rat offspring, taking into account involvement of the HPA system. Dams were subject to stress during gestation and were treated with fluoxetine (2×/5 mg/kg/day) prior to parturition and throughout lactation. Four groups of adult male offspring were used: 1. Control+Vehicle, 2. Control+Fluoxetine, 3. Prenatal Stress+Vehicle, 4. Prenatal Stress+Fluoxetine. Results show that post-operative pain, measured as hypersensitivity to mechanical stimuli after hind paw incision, was decreased in adult offspring subject to prenatal stress alone and increased in offspring developmentally exposed to fluoxetine alone. Moreover, post-operative pain was normalized in prenatally stressed offspring exposed to fluoxetine. This was paralleled by a decrease in corticosteroid binding globulin (CBG) levels in prenatally stressed offspring and a normalization of serum CBG levels in prenatally stressed offspring developmentally exposed to fluoxetine. Thus, developmental fluoxetine exposure normalizes the long-term effects of maternal adversity on post-operative pain in offspring and these effects may be due, in part, to the involvement of the HPA system.

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Section: Discussioncontrasting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

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Developmental Fluoxetine Exposure Normalizes the Long-Term Effects of Maternal Stress on Post-Operative Pain in Sprague-Dawley Rat Offspring

et al. 2013

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“…These higher 5-HT levels may result in increased pain inhibition. In addition, direct stimulation of the 5-HT1A receptor through injection of buspirone, a 5-HT1A receptor agonist, in mothers exposed to restraint stress during gestation, alleviates the increased inflammatory hypersensitivity upon formalin injection in adult offspring (Butkevich, Mikhailenko, Vershinina, Semionov et al, 2011;Butkevich, Mikhailenko, Vershinina, Otellin, & Aloisi, 2011).…”

Section: Experimental Evidencementioning

confidence: 99%

Perinatal maternal stress and serotonin signaling: Effects on pain sensitivity in offspring

Knaepen

Pawluski

Patijn

et al. 2013

Developmental Psychobiology

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It has been estimated that 20% of pregnant women are facing perinatal stress and depression. Perinatal maternal stress has been shown to increase pain sensitivity in offspring. For the treatment of their depressive symptoms, pregnant women are frequently prescribed selective serotonin reuptake inhibitors (SSRIs). Since the descending pain inhibitory circuit matures perinatally, perinatal SSRI exposure has been shown to affect pain sensitivity in offspring. In the present review, we summarize experimental and clinical evidence for the effect of perinatal maternal stress and SSRI exposure on pain sensitivity in offspring. Both experimental and clinical studies show the effect of perinatal maternal stress on regulation of the hypothalamic-pituitary-adrenal (HPA) system and the serotonin pain inhibitory system. Alterations in these two systems likely underlie long-term alterations in the development of pain sensitivity. This review sheds light on the effect of perinatal maternal stress and treatment with SSRIs on offspring pain sensitivity, in relation to the developing HPA system and 5-HT signaling.

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“…Based on these results, we suggest that the modulation of 5-HT 1A and 5-HT 3 receptors is involved in the antidepressant-like action of (p-ClPhSe) 2 in old rats. It is worth mentioning that an important drug used for the clinical treatment of anxiety and depression, buspirone, is a full agonist of presynaptic and a partial agonist of postsynaptic 5-HT 1A receptors (Butkevich et al 2011). In addition, clinical and preclinical studies have suggested that 5-HT 3 receptors may be a relevant target in the treatment of affective disorders (Bétry et al 2011).…”

Section: Discussionmentioning

confidence: 99%

p-Chloro-diphenyl diselenide, an organoselenium compound, with antidepressant-like and memory enhancer actions in aging male rats

et al. 2011

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The aim of this study was to evaluate the protective effects of p-chloro-diphenyl diselenide (p-ClPhSe)(2) on depressant-like action and cognitive impairment caused by aging in male rats. For this purpose, old rats were orally treated with (p-ClPhSe)(2) (10 or 25 mg/kg) for seven days. Then, rats were tested in experimental models of ambulation, memory and depression. In addition, Na(+) K(+) ATPase activity and reactive species (RS) levels were measured in rat cortex and hippocampus. Our findings demonstrated that treatment of old rats with (p-ClPhSe)(2) (10 and 25 mg/kg) reversed spatial memory deficit in the object location test and depressant-like action in the forced swimming test (FST) caused by aging. Reduction in exploratory behavior (rearings) in the open-field test caused by aging was not altered by (p-ClPhSe)(2) administration. Moreover, the increase of RS levels and inhibition of Na(+) K(+) ATPase activity in cortex and hippocampus resulting from aging were restored by the highest dose of (p-ClPhSe)(2). To assess the mechanisms involved in the antidepressant-like effect of (p-ClPhSe)(2), old rats received WAY100635 (0.1 mg/kg, subcutaneous, a selective 5-HT(1A)R antagonist), ritanserin (1 mg/kg, intraperitoneal, a 5-HT(2A/2C)R antagonist) or ondansetron (1 mg/kg, intraperitoneal, a 5-HT(3)R antagonist) 15 min before (p-ClPhSe)(2) (25 mg/kg) treatment. After 30 min, the FST was performed. Results showed that in addition to the antioxidant action, the modulation of 5-HT(1A) and 5-HT(3) receptors may be at least partly involved in the antidepressant-like action elicited by (p-ClPhSe)(2) in old rats. These findings highlight the beneficial potential of (p-ClPhSe)(2) in aged male rats.

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Maternal buspirone protects against the adverse effects of in utero stress on emotional and pain-related behaviors in offspring

Cited by 19 publications

References 63 publications

Developmental Fluoxetine Exposure Normalizes the Long-Term Effects of Maternal Stress on Post-Operative Pain in Sprague-Dawley Rat Offspring

Developmental Fluoxetine Exposure Normalizes the Long-Term Effects of Maternal Stress on Post-Operative Pain in Sprague-Dawley Rat Offspring

Perinatal maternal stress and serotonin signaling: Effects on pain sensitivity in offspring

p-Chloro-diphenyl diselenide, an organoselenium compound, with antidepressant-like and memory enhancer actions in aging male rats

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