Maternal behavior as an early modulator of neurobehavioral offspring responses by Sprague-Dawley rats

Sequeira‐Cordero, Andrey; Masís-Calvo, Marianela; Mora-Gallegos, Andrea; Trías, Jaime Fornaguera

doi:10.1016/j.bbr.2012.09.028

Cited by 21 publications

(15 citation statements)

References 72 publications

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“…Literature from other animal models shows similar results. Rat pups that receive more maternal care during the first 10 days of life show reduced fearfulness, reduced non-exploratory locomotion, and increased exploration in a novel environment (Caldji et al 1998;Cladji et al, 2000a;Liu et al, 1997;Masís-Calvo et al, 2013;Meaney, 2001;Sequeira-Cordero et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Caldji et al, 1998;Caldji et al, 2000a;Fairbanks, 1996;Foyer et al, 2016;Liu et al, 1997). (Caldji et al, 1998;Caldji et al, 2000a;Champagne, 2008;Francis et al, 2000;Gudsnuk and Champagne, 2011;Jensen and Champagne;Masís-Calvo et al, 2013;Meaney, 2001;Sequeira-Cordero et al, 2013;Zhang et al, 2005). Unlike rodents, scientific literature on maternal care shown by female domestic dogs during the first weeks post-partum is still scarce (Arteaga et al, 2012;Foyer et al, 2016;Guardini et al, 2015;Pal, 2005;Rheingold, 1963;Scott and Fuller, 1965) and its effects on the behaviour of adult offspring have been investigated only very recently (Foyer et al, 2016).…”

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confidence: 99%

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Influence of morning maternal care on the behavioural responses of 8-week-old Beagle puppies to new environmental and social stimuli

Guardini

Mariti

Bowen

et al. 2016

Applied Animal Behaviour Science

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Influence of morning maternal care on the behavioural responses of 8-week-old Beagle puppies to new environmental and social stimuli

Guardini

Mariti

Bowen

et al. 2016

Applied Animal Behaviour Science

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“…At the time of weaning (PND 21), male offspring that have experienced low-LG have continued reductions in hippocampal BDNF and NMDAR subunit expression [31; 36] as well as reduced synaptophysin and NCAM protein levels leading to reduced neuronal survival [31; 56]. Amongst juvenile (PND 40) male offspring of low-LG rat dams, altered serotonin (5-HT) turnover rates are apparent in the PFC, ventral striatum, and hippocampus [57; 58]. In female offspring, variation in protein and mRNA levels within the MPOA and VTA associated with maternal LG can be observed as early as PND 6.…”

Section: Neurobiological and Behavioral Impact Of Variation In Matmentioning

confidence: 99%

Influence of maternal care on the developing brain: Mechanisms, temporal dynamics and sensitive periods

Curley

Champagne

2016

Frontiers in Neuroendocrinology

206

117

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Variation in maternal care can lead to divergent developmental trajectories in offspring with implications for neuroendocrine function and behavioral phenotypes. Study of the long-term outcomes associated with mother-infant interactions suggests complex mechanisms linking the experience of variation in maternal care and these neurobiological consequences. Through integration of genetic, molecular, cellular, neuroanatomical, and neuroendocrine approaches, significant advances in our understanding of these complex pathways have been achieved. In this review, we will consider the impact of maternal care on male and female offspring development with a particular focus on the issues of timing and mechanism. Identifying the period of sensitivity to maternal care and the temporal dynamics of the molecular and neuroendocrine changes that are a consequence of maternal care represents a critical step in the study of mechanism.

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“…According to the current knowledge, PFC and HPC are commonly associated with depression, as well as in antidepressant response (Bredy et al, 2003 ; Cerqueira et al, 2007 ; Drevets et al, 2008 ; Bagot et al, 2009 ; Bessa et al, 2009 ; Monroy et al, 2010 ; Sequeira-Cordero et al, 2013 ). However, some study showed that antidepressant intervention had a greater effect on 5-HT level of HPC compared to that in the PFC (Bekris et al, 2005 ; Pitychoutis et al, 2012 ), while other study showed a better linkage between the antidepressant-treated behavioral outcomes and the 5-HT system in the PFC rather than that in the HPC (Mikail et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Study of Sex Differences in Duloxetine Efficacy for Depression in Transgenic Mouse Models

Jiang

et al. 2017

Front. Cell. Neurosci.

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Clinical evidences show sex differences in risk of developing depressive disorders as well as effect of antidepressants in depression treatment. However, whether such a sex-dependent risk of depression and efficacy of antidepressants is dependent on endogenous estrogen level remain elusive. The aim of this study is to explore the molecular mechanisms of sex differences in antidepressant duloxetine. In the present study, we used genetic knockout or overexpression estrogen-synthesizing enzyme aromatase (Ar) gene as models for endogenous estrogen deficiency and elevation endogenous estrogen, respectively, to examine the anti-depressive efficacy of duloxetine in males and females by force swimming test (FST). We also measured the sex-specific effect of duloxetine on dopamine and serotonin (5-HT) metabolisms in frontal cortex and hippocampus (HPC). Elevation of brain endogenous estrogen in male and female mice showed a reduction of immobility time in FST compared to control mice. Estrogen deficiency in females showed poor response to duloxetine treatment compared to sex-matched wildtype (WT) or aromatase transgenic mice. In contrast, male mice with estrogen deficiency showed same anti-depressive response to duloxetine treatments as aromatase transgenic mice. Our data showed that the sex different effect of endogenous estrogen on duloxetine-induced anti-depressive behavioral change is associated with brain region-specific changes of dopamine (DA) and 5-HT system. Endogenous estrogen exerts antidepressant effects in both males and females. Lacking of endogenous estrogen reduced antidepressive effect of duloxetine in females only. The endogenous estrogen level alters 5-HT system in female mainly, while both DA and 5-HT metabolisms were regulated by endogenous estrogen levels after duloxetine administration.

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Maternal behavior as an early modulator of neurobehavioral offspring responses by Sprague-Dawley rats

Cited by 21 publications

References 72 publications

Influence of morning maternal care on the behavioural responses of 8-week-old Beagle puppies to new environmental and social stimuli

Influence of morning maternal care on the behavioural responses of 8-week-old Beagle puppies to new environmental and social stimuli

Influence of maternal care on the developing brain: Mechanisms, temporal dynamics and sensitive periods

Study of Sex Differences in Duloxetine Efficacy for Depression in Transgenic Mouse Models

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