Maternal antioxidant treatment prevents the adverse effects of prenatal stress on the offspring's brain and behavior

Scott, Hannah; Phillips, Tom J.; Sze, Ying; Alfieri, Alessio; Rogers, Mark F.; Volpato, Viola; Case, C. P.; Brunton, Paula

doi:10.1016/j.ynstr.2020.100281

Cited by 22 publications

(15 citation statements)

References 94 publications

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“…This is in line with a prior report by Marmorstein et al who found that parental diagnosis of MDD was associated with an increased risk for obesity in offspring 45 . The exact mechanism remains unclear, but according to previous studies, the mechanism of maternal psychological distress on an offspring's brain and behavior are likely multi‐factorial, including HPA axis activation, maternal microbiome, trans‐placental environment, epigenetics, and inflammation 46,47 . Maternal anxiety was positively associated with offspring VAT, whereas maternal depression had no such association.…”

Section: Discussionsupporting

confidence: 89%

“…45 The exact mechanism remains unclear, but according to previous studies, the mechanism of maternal psychological distress on an offspring's brain and behavior are likely multi-factorial, including HPA axis activation, maternal microbiome, trans-placental environment, epigenetics, and inflammation. 46,47 Maternal anxiety was positively associated with offspring VAT, whereas maternal depression had no such association. These results emphasize the importance of maternal mental health evaluation and intervention.…”

Section: Prenatal Environment: Maternal Influencementioning

confidence: 94%

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Association between visceral adipose tissue and major depressive disorder across the lifespan: A scoping review

et al. 2021

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Objectives Increasing evidence supports a bidirectional relationship between major depressive disorder (MDD) and obesity, but the role of visceral adipose tissue (VAT) as a measure of obesity in relation to MDD is not well understood. Here we review literature investigating the link between MDD and VAT in terms of biomarkers, sex differences, and aging. Methods PubMed, EMBASE, PsycINFO, and CINAHL searches were conducted on December 11, 2020. No date or language limits were imposed. Major concepts searched were Depressive Disorder linked with Adipose Tissue, White, Hypothalmo–Hypophyseal System, and Pituitary–Adrenal System in addition to keywords. A final set of 32 items meeting criteria for inclusion. Results Converging biological evidence suggests a significant bidirectional relationship between VAT and MDD across the lifespan. In adulthood, greater VAT was associated with increased risk for depression, especially in vulnerable groups such as individuals who are overweight/obese, postmenopausal women, and individuals with comorbid medical or psychiatric illness. In older adults, sarcopenia had an impact on the relationship between abnormal VAT and risk of depression. Additionally, sex differences emerged as a potential factor affecting the strength of the association between VAT and depression. Conclusions Elucidating the pathophysiological mechanisms associated with increased rates of depression in obese individuals will be crucial for developing specific treatment strategies that seek to improve outcomes in individuals with comorbid depression and obesity. Moreover, identifying age‐ and sex‐specific risk factors may contribute to a more personalized medicine approach, thereby improving the quality of clinical care.

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Section: Discussionsupporting

confidence: 89%

Section: Prenatal Environment: Maternal Influencementioning

confidence: 94%

Association between visceral adipose tissue and major depressive disorder across the lifespan: A scoping review

et al. 2021

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“…Psychosocial stress is known to contribute to oxidative stress in the placenta [ 126 ]. The Programming of Intergenerational Stress Mechanisms study examined the association of maternal lifetime stress, negative life events, depression, and post-traumatic stress disorder symptom scores with placental mtDNA copy number [ 127 ].…”

Section: Environmental Factors During Pregnancy and Mtdna Copy Number In Newbornsmentioning

confidence: 99%

Mitochondrial DNA Copy Number and Developmental Origins of Health and Disease (DOHaD)

Fukunaga

2021

IJMS

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Mitochondrial dysfunction is known to contribute to mitochondrial diseases, as well as to a variety of aging-based pathologies. Mitochondria have their own genomes (mitochondrial DNA (mtDNA)) and the abnormalities, such as point mutations, deletions, and copy number variations, are involved in mitochondrial dysfunction. In recent years, several epidemiological studies and animal experiments have supported the Developmental Origin of Health and Disease (DOHaD) theory, which states that the environment during fetal life influences the predisposition to disease and the risk of morbidity in adulthood. Mitochondria play a central role in energy production, as well as in various cellular functions, such as apoptosis, lipid metabolism, and calcium metabolism. In terms of the DOHaD theory, mtDNA copy number may be a mediator of health and disease. This paper summarizes the results of recent epidemiological studies on the relationship between environmental factors and mtDNA copy number during pregnancy from the perspective of DOHaD theory. The results of these studies suggest a hypothesis that mtDNA copy number may reflect environmental influences during fetal life and possibly serve as a surrogate marker of health risks in adulthood.

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“…In other words, PS is the stress experienced by pregnant women before giving birth ( 3 ). Exposure to adverse stimuli during pregnancy can cause perpetual negative effects on emotion and cognition, thereby increasing the risk of psychiatric disorders in offspring ( 4 , 5 ). Maternal stress has been described as an important component in the development of offspring's cerebrum, altering the susceptibility to diseases in later life ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

“…Life stress events including work stress, family conflict, and economic difficulties adversely affect women during pregnancy ( 1 ). In rodent models, harmful stimulation during pregnancy can induce behavioral changes, including abnormal social behaviors, heightened anxiety-like behavior, and cognitive deficits in offspring ( 5 , 11 ). Although little is known about it, the complex interaction of the cellular and molecular mechanisms leads to abnormal and pathological results caused by maternal PS.…”

Section: Introductionmentioning

confidence: 99%

Trends in Research of Prenatal Stress From 2011 to 2021: A Bibliometric Study

Dong

Chen²,

Wang³

et al. 2022

Front. Pediatr.

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BackgroundMaternal stress during pregnancy can raise the risk of mental disorders in offspring. The continuous emergence of clinical concepts and the introduction of new technologies are great challenges. In this study, through bibliometric analysis, the research trends and hotspots on prenatal stress (PS) were explored to comprehend clinical treatments and recommend future scientific research directions.MethodsStudies on PS published on the Web of Science Core Collection (WoSCC) database between 2011 and 2021 were reviewed. Bibliometric analysis was conducted according to the number of publications, keywords, journals, citations, affiliations, and countries. With the data collected from the WoSCC, visualization of geographic distribution; clustering analysis of keywords, affiliations, and authors; and descriptive analysis and review of PS were carried out.ResultsA total of 7,087 articles published in 2011–2021 were retrieved. During this period, the number of publications increased. Psychoneuroendocrinology is the leading journal on PS. The largest contributor was the United States. The University of California system was leading among institutions conducting relevant research. Wang H, King S, and Tain YL were scholars with significant contributions. Hotspots were classified into four clusters, namely, pregnancy, prenatal stress, oxidative stress, and growth.ConclusionThe number of studies on PS increased. Journals, countries, institutions, researchers with the most contributions, and most cited articles worldwide were extracted. Studies have mostly concentrated on treating diseases, the application of new technologies, and the analysis of epidemiological characteristics. Multidisciplinary integration is becoming the focus of current development. Epigenetics is increasingly used in studies on PS. Thus, it constitutes a solid foundation for future clinical medical and scientific research.

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Maternal antioxidant treatment prevents the adverse effects of prenatal stress on the offspring's brain and behavior

Cited by 22 publications

References 94 publications

Association between visceral adipose tissue and major depressive disorder across the lifespan: A scoping review

Association between visceral adipose tissue and major depressive disorder across the lifespan: A scoping review

Mitochondrial DNA Copy Number and Developmental Origins of Health and Disease (DOHaD)

Trends in Research of Prenatal Stress From 2011 to 2021: A Bibliometric Study

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