Maternal and congenital syphilis in Shanghai, China, 2002 to 2006

Zhu, Li; Qin, Min; Du, Li; Xie, Ri-Hua; Wong, Tom; Wen, Shi Wu

doi:10.1016/j.ijid.2009.09.009

Cited by 52 publications

(37 citation statements)

References 12 publications

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“…The likelihood of vertical transmission in early syphilis is nearly 100%. 10,24 Early screening, rescreening, and timely appropriate treatment of maternal syphilis cases is instrumental in preventing CS 9,15,17,25 …”

Section: Discussionmentioning

confidence: 99%

“…16 Another study compared infected pregnant women who did or did not complete treatment, but it did not report on success preventing CS. 17 Appropriate treatment of pregnant women with syphilis has been found to be 98% effective in preventing CS. 18,19 Assessing maternal syphilis cases that did and did not lead to CS can help determine the impact of screening and appropriate timely treatment on preventing cases of CS.…”

mentioning

confidence: 99%

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Effectiveness of Prenatal Screening and Treatment to Prevent Congenital Syphilis, Louisiana and Florida, 2013–2014

Matthias¹,

Rahman²,

Newman³

et al. 2017

Sexual Trans Dis

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Background: From 2012 to 2014, rates of congenital syphilis increased in Louisiana and Florida. We evaluated the effectiveness of early (first or second) and third trimester syphilis screening for the prevention of congenital syphilis in these high-morbidity states. Methods: Reported syphilis cases among pregnant women in Louisiana and Florida during January 1, 2013, to December 31, 2014, were reviewed for documented screening for syphilis in the first 2 trimesters and third trimester. Pregnant women with syphilis were linked to congenital syphilis records and stratified by whether the pregnancy led to a reported congenital syphilis case. Results: Seven hundred ten pregnant women with syphilis in Louisiana and Florida were linked to 155 congenital syphilis cases. Three hundred seventy (52%) pregnant women with syphilis were staged as early syphilis (n = 270) or high-titer late or unknown duration-latent syphilis (n = 100), and 109 (70% of the total) were linked to congenital syphilis cases. Screening in the first 2 trimesters identified 513 pregnant women who tested positive for syphilis, and 470 (92%) potential congenital syphilis were averted. One hundred nine pregnant women tested positive for syphilis in the third trimester, and 85 (78%) had babies without congenital syphilis. During their pregnancy, 85 (12%) women tested negative at least once, and 55 (65%) had babies with congenital syphilis. Thirty-nine women had no reported syphilis screening 30 days or longer before delivery. Conclusions: Screening for syphilis both early and in the third trimester prevented many pregnant women with syphilis from having a baby with congenital syphilis. Preventing all congenital syphilis would likely require preventing all syphilis among women.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Effectiveness of Prenatal Screening and Treatment to Prevent Congenital Syphilis, Louisiana and Florida, 2013–2014

Matthias¹,

Rahman²,

Newman³

et al. 2017

Sexual Trans Dis

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show abstract

“…35 Finally, the timing of prenatal care, a crucial aspect of congenital syphilis prevention, was not determined. 36 Timely prenatal care, preferably in the first trimester, is essential for effective syphilis prevention programmes. 37 The elimination of congenital syphilis is a global health priority, but organizing effective prenatal screening, especially in the resource-constrained settings most heavily affected by congenital syphilis, remains a substantial challenge.…”

Section: Researchmentioning

confidence: 99%

Syphilis test availability and uptake at medical facilities in southern China

Yang¹,

Tucker²,

Wang³

et al. 2011

Bull World Health Org

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“…Some studies even recommend a second dose for pregnant women with early syphilis. [11][12][13][14] Treatment should be followed with a sonogram examination of fetus. Ultrasonogram should always be done before treatment so as to assess the outcome, as sonographic evidence of congenital syphilis is a sign of treatment failure.…”

Section: 7%mentioning

confidence: 99%

Retrospective analysis of burden of maternal syphilis and the outcome in the fetus in a tertiary care centre

et al. 2018

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Background: Syphilis in pregnancy has its own significance with regards to the outcome of pregnancy. In the meanwhile, it also reflects the effectiveness of health system in the community.Methods: A retrospective study was carried out in a tertiary care centre in Chennai between January 2014 and July 2015 to determine the seroprevalence of syphilis in pregnant women. A total of 4423 ANC mother attending the hospital were included in the study.Results: Of the 4423 cases studied, 7 cases were found to be positive for RPR accounting to the prevalence of 0.15%. One mother was symptomatic, presenting with condyloma lata. TPHA was positive in 2 cases (28.5%) Most common association was with HIV infection, 2/7 (28.5%). All the RPR positive patients were treated with tablet erythromycin 500 mg qid × 14 days. Epidose for the partner was given. The outcome was uneventful except for one. A single case of congenital syphilis was reported.Conclusions: Though the prevalence of RPR positive in routine screening is less, the outcome of single congenital syphilis is worrisome. To conclude, although the prevalence of syphilis (0.1%) is low, routine screening of asymptomatic ante natal women is recommended to reduce the incidence of congenital syphilis & perinatal complications and it is always better to treat the ANC mothers with syphilis with Penicillin, preferably with a second dose also.

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Maternal and congenital syphilis in Shanghai, China, 2002 to 2006

Abstract: There has been a resurgence of congenital syphilis in Shanghai, China, especially in the migrating population and other populations with a lower socioeconomic status.

Cited by 52 publications

References 12 publications

Effectiveness of Prenatal Screening and Treatment to Prevent Congenital Syphilis, Louisiana and Florida, 2013–2014

Effectiveness of Prenatal Screening and Treatment to Prevent Congenital Syphilis, Louisiana and Florida, 2013–2014

Syphilis test availability and uptake at medical facilities in southern China

Retrospective analysis of burden of maternal syphilis and the outcome in the fetus in a tertiary care centre

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